6MA7
Human CYP3A4 bound to an inhibitor fluconazole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cytochrome P450 3A4 | polymer | 487 | 55759.8 | 1 | UniProt (P08684) Pfam (PF00067) In PDB | Homo sapiens (Human) | 1,8-cineole 2-exo-monooxygenase,Albendazole monooxygenase,Albendazole sulfoxidase,CYPIIIA3,CYPIIIA4,Cholesterol 25-hydroxylase,Cytochrome P450 3A3,Cytochrome P450 HLp,Cytochrome P450 NF-25,Cytochrome P450-PCN1,Nifedipine oxidase,Quinine 3-monooxygenase,Taurochenodeoxycholate 6-alpha-hydroxylase |
2 | A | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
3 | A | 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL | non-polymer | 306.3 | 1 | Chemie (TPF) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
6 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 23 - 503 (UniProt: P08684)
PDB | External Database | Details |
---|---|---|
Met 21 | - | initiating methionine |
Ala 22 | - | expression tag |
Thr 269 | Val 269 | conflict |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 55759.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1063.0 | |
All* | Total formula weight | 56822.7 |