1PB5
| NMR Structure of a Prototype LNR Module from Human Notch1 | 分子名称: | CALCIUM ION, Neurogenic locus notch homolog protein 1 | 著者 | Vardar, D, North, C.L, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | 登録日 | 2003-05-14 | 公開日 | 2003-06-17 | 最終更新日 | 2024-10-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Nuclear Magnetic Resonance Structure of a Prototype Lin12-Notch Repeat Module from Human Notch1 Biochemistry, 42, 2003
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7ABV
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3L95
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6XSW
| Structure of the Notch3 NRR in complex with an antibody Fab Fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... | 著者 | Bard, J. | 登録日 | 2020-07-16 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2, 2021
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3I08
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7DXI
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4ZLP
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2OO4
| Structure of LNR-HD (Negative Regulatory Region) from human Notch 2 | 分子名称: | CALCIUM ION, GLYCEROL, Neurogenic locus notch homolog protein 2, ... | 著者 | Gordon, W.R, Vardar-Ulu, D, Histen, G, Sanchez-Irizarry, C, Aster, J.C, Blacklow, S.C. | 登録日 | 2007-01-25 | 公開日 | 2007-04-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.003 Å) | 主引用文献 | Structural basis for autoinhibition of Notch Nat.Struct.Mol.Biol., 14, 2007
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3ETO
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5CZV
| Crystal structure of Notch3 NRR in complex with 20350 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 20350 heavy chain, ... | 著者 | Hu, T, Fryer, C, Chopra, R, Clark, K. | 登録日 | 2015-08-01 | 公開日 | 2016-06-01 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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5CZX
| Crystal structure of Notch3 NRR in complex with 20358 Fab | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 20358 Fab heavy chain, ... | 著者 | Hu, T, Fryer, C, Chopra, R, Clark, K. | 登録日 | 2015-08-01 | 公開日 | 2016-06-01 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35, 2016
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7S05
| Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Li, H, Li, H. | 登録日 | 2021-08-30 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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7S06
| Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta | 著者 | Li, H, Li, H. | 登録日 | 2021-08-30 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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