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PDB: 672 件
7LZ2
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BU of 7lz2 by Molmil
Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with methionine
分子名称: BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ...
著者Gangwar, S.P, Green, M.N, Sobolevsky, A.I.
登録日2021-03-08
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
Mol.Cell, 81, 2021
7LZI
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Structure of the glutamate receptor-like channel AtGLR3.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, Glutamate receptor 3.4
著者Gangwar, S.P, Green, M.N, Sobolevsky, A.I.
登録日2021-03-09
公開日2021-07-28
最終更新日2021-08-18
実験手法ELECTRON MICROSCOPY (4.39 Å)
主引用文献Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
Mol.Cell, 81, 2021
7LZH
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Structure of the glutamate receptor-like channel AtGLR3.4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, ...
著者Gangwar, S.P, Green, M.N, Sobolevsky, A.I.
登録日2021-03-09
公開日2021-07-28
最終更新日2021-08-18
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
Mol.Cell, 81, 2021
7LZ0
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BU of 7lz0 by Molmil
Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with glutamate
分子名称: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ...
著者Gangwar, S.P, Green, M.N, Sobolevsky, A.I.
登録日2021-03-08
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
Mol.Cell, 81, 2021
7LZ1
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BU of 7lz1 by Molmil
Structure of glutamate receptor-like channel GLR3.4 ligand-binding domain in complex with serine
分子名称: GLYCEROL, Glutamate receptor 3.4, SERINE, ...
著者Gangwar, S.P, Green, M.N, Sobolevsky, A.I.
登録日2021-03-08
公開日2021-07-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4.
Mol.Cell, 81, 2021
3LSW
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BU of 3lsw by Molmil
Aniracetam bound to the ligand binding domain of GluA3
分子名称: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, GLUTAMIC ACID, GluA2 S1S2 domain, ...
著者Ahmed, A.H, Oswald, R.E.
登録日2010-02-13
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3IJX
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BU of 3ijx by Molmil
Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide
分子名称: 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, GLUTAMIC ACID, Glutamate receptor 2, ...
著者Ptak, C.P, Ahmed, A.H, Oswald, R.E.
登録日2009-08-05
公開日2009-09-15
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.881 Å)
主引用文献Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
Biochemistry, 48, 2009
1P1W
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BU of 1p1w by Molmil
Crystal structure of the GluR2 ligand-binding core (S1S2J) with the L483Y and L650T mutations and in complex with AMPA
分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 2 precursor, SULFATE ION
著者Armstrong, N, Mayer, M.L, Gouaux, E.
登録日2003-04-14
公開日2003-06-10
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Proc.Natl.Acad.Sci.USA, 100, 2003
7LVT
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BU of 7lvt by Molmil
Structure of full-length GluK1 with L-Glu
分子名称: Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
著者Meyerson, J.R, Selvakumar, P.
登録日2021-02-26
公開日2021-11-03
最終更新日2021-11-10
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural and compositional diversity in the kainate receptor family.
Cell Rep, 37, 2021
3KFM
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BU of 3kfm by Molmil
Crystal Structure of the GluA4 Ligand-Binding domain L651V mutant in complex with kainate
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 4
著者Gill, A, Madden, D.R.
登録日2009-10-27
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
J.Neurosci., 30, 2010
1NNP
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BU of 1nnp by Molmil
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions.
分子名称: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, Glutamate receptor 2, SULFATE ION
著者Lunn, M.L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S.
登録日2003-01-14
公開日2003-03-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity.
J.Med.Chem., 46, 2003
1P1Q
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BU of 1p1q by Molmil
Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA
分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 2, ZINC ION
著者Armstrong, N, Mayer, M.L, Gouaux, E.
登録日2003-04-13
公開日2003-06-10
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
Proc.Natl.Acad.Sci.USA, 100, 2003
6HCC
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BU of 6hcc by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.
分子名称: 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), ACETATE ION, CHLORIDE ION, ...
著者Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
登録日2018-08-14
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.617 Å)
主引用文献Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6HCB
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BU of 6hcb by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION.
分子名称: 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Laulumaa, S, Masternak, M, Frydenvang, K, Kastrup, J.S.
登録日2018-08-14
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6HCA
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BU of 6hca by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION
分子名称: 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
登録日2018-08-14
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.882 Å)
主引用文献Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6DLZ
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BU of 6dlz by Molmil
Open state GluA2 in complex with STZ after micelle signal subtraction
分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit
著者Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
登録日2018-06-04
公開日2018-08-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6IRG
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BU of 6irg by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
著者Zhang, J, Chang, S, Zhang, X, Zhu, S.
登録日2018-11-12
公開日2019-01-16
最終更新日2019-06-05
実験手法ELECTRON MICROSCOPY (5.5 Å)
主引用文献Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6IRA
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BU of 6ira by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
著者Zhang, J, Chang, S, Zhang, X, Zhu, S.
登録日2018-11-12
公開日2019-01-16
最終更新日2019-06-05
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6IRH
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Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
著者Zhang, J, Chang, S, Zhang, X, Zhu, S.
登録日2018-11-12
公開日2019-01-16
最終更新日2019-06-05
実験手法ELECTRON MICROSCOPY (7.8 Å)
主引用文献Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
6FAZ
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BU of 6faz by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution.
分子名称: 1,2-ETHANEDIOL, 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, ...
著者Nielsen, L, Laulumaa, S, Kastrup, J.S.
登録日2017-12-18
公開日2018-11-21
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.
J. Med. Chem., 61, 2018
6F29
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BU of 6f29 by Molmil
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
分子名称: (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, CHLORIDE ION, Glutamate receptor ionotropic, ...
著者Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
登録日2017-11-23
公開日2018-02-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
J. Med. Chem., 61, 2018
6JFY
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GluK3 receptor trapped in Desensitized state
分子名称: Glutamate receptor ionotropic, kainate 3
著者Kumari, J, Kumar, J.
登録日2019-02-13
公開日2019-07-24
最終更新日2019-11-06
実験手法ELECTRON MICROSCOPY (7.4 Å)
主引用文献Structural and Functional Insights into GluK3-kainate Receptor Desensitization and Recovery.
Sci Rep, 9, 2019
6DM1
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BU of 6dm1 by Molmil
Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction
分子名称: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit, ...
著者Twomey, E.C, Yelshanskaya, M.V, Vassilevski, A.A, Sobolevsky, A.I.
登録日2018-06-04
公開日2018-08-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
Neuron, 99, 2018
6HCH
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BU of 6hch by Molmil
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION.
分子名称: 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide), ACETATE ION, CHLORIDE ION, ...
著者Laulumaa, S, Hansen, K.V, Frydenvang, K, Kastrup, J.S.
登録日2018-08-15
公開日2019-04-03
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.
Acs Med.Chem.Lett., 10, 2019
6IRF
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BU of 6irf by Molmil
Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I
分子名称: Glutamate receptor ionotropic, NMDA 1, NMDA 2A
著者Zhang, J, Chang, S, Zhang, X, Zhu, S.
登録日2018-11-12
公開日2019-01-16
最終更新日2019-06-05
実験手法ELECTRON MICROSCOPY (5.1 Å)
主引用文献Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018

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