6HCC

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION.

Summary for 6HCC

Entry DOI	10.2210/pdb6hcc/pdb
Descriptor	Glutamate receptor 2, 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE), GLUTAMIC ACID, ... (9 entities in total)
Functional Keywords	ampa receptor, glua2, ligand-binding domain, glua2-s1s2j-n775s, membrane protein, signaling protein, positive allosteric modulator
Biological source	Rattus norvegicus (Norway Rat) More
Total number of polymer chains	2
Total formula weight	60952.02
Authors	Laulumaa, S.,Hansen, K.V.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2018-08-14, release date: 2019-04-03, Last modification date: 2024-01-17)
Primary citation	Laulumaa, S.,Hansen, K.V.,Masternak, M.,Drapier, T.,Francotte, P.,Pirotte, B.,Frydenvang, K.,Kastrup, J.S. Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor. Acs Med.Chem.Lett., 10:243-247, 2019 Cited by PubMed: 30891120 DOI: 10.1021/acsmedchemlett.8b00369 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.617 Å)

Structure validation