Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue FXW A 301 |
| Chain | Residue |
| A | LYS104 |
| B | LYS104 |
| B | PRO105 |
| B | PHE106 |
| B | MET107 |
| B | SER108 |
| B | SER217 |
| B | LYS218 |
| B | GLY219 |
| B | SER242 |
| B | HOH581 |
| A | PRO105 |
| A | PHE106 |
| A | MET107 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | GLY219 |
| A | SER242 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue GLU A 302 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | TYR220 |
| A | HOH446 |
| A | HOH468 |
| A | HOH499 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | SER140 |
| A | LYS144 |
| A | ARG148 |
| A | ACT314 |
| A | HOH413 |
| A | HOH440 |
| A | HOH497 |
| A | HOH646 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | LYS82 |
| A | LYS116 |
| A | HOH525 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | ARG148 |
| A | TRP159 |
| A | ARG163 |
| A | ACT314 |
| A | HOH603 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | MET19 |
| A | HIS23 |
| A | ARG31 |
| A | HOH427 |
| B | LYS258 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 307 |
| Chain | Residue |
| A | HIS46 |
| A | LYS240 |
| A | GLN244 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | TYR80 |
| A | LYS116 |
| A | LYS185 |
| A | HOH437 |
| A | HOH643 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | LYS4 |
| A | THR5 |
| A | HOH415 |
| A | HOH457 |
| A | HOH592 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 310 |
| Chain | Residue |
| A | GLU27 |
| A | GLY28 |
| A | ARG31 |
| A | LYS52 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 311 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 312 |
| Chain | Residue |
| A | ASP248 |
| B | ASN214 |
| B | LEU215 |
| B | ASP216 |
| B | SER217 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 313 |
| Chain | Residue |
| A | ASN214 |
| A | LEU215 |
| A | ASP216 |
| A | SER217 |
| A | HOH602 |
| B | ASP248 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 314 |
| Chain | Residue |
| A | LYS144 |
| A | ARG148 |
| A | SO4303 |
| A | GOL305 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 315 |
| Chain | Residue |
| A | GLU97 |
| A | ASP101 |
| A | PHE102 |
| A | HOH645 |
| B | LYS104 |
| site_id | AD7 |
| Number of Residues | 13 |
| Details | binding site for residue GLU B 301 |
| Chain | Residue |
| B | THR143 |
| B | GLU193 |
| B | TYR220 |
| B | HOH444 |
| B | HOH453 |
| B | HOH500 |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| A | LYS183 |
| B | ARG31 |
| B | HOH446 |
| B | HOH454 |
| B | HOH459 |
| B | HOH489 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | HIS46 |
| B | PRO167 |
| B | GLN244 |
| B | HOH427 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH410 |
| B | HOH417 |
| B | HOH442 |
| B | HOH507 |
| B | HOH599 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| B | GLU27 |
| B | GLY28 |
| B | ASN29 |
| B | GLU30 |
| B | HOH418 |
| B | HOH479 |
| site_id | AE3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| B | VAL7 |
| B | GLY81 |
| B | LYS82 |
| B | ALA83 |
| B | ASP84 |
| B | HOH404 |
| B | HOH458 |
| B | HOH468 |
| B | HOH630 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 307 |
| Chain | Residue |
| B | ARG148 |
| B | TRP159 |
| B | ARG163 |
| B | HOH460 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 308 |
| Chain | Residue |
| A | HOH546 |
| B | ASN22 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 309 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | PRO89 | |
| B | SER142 | |
| B | THR143 | |
| B | GLU193 | |
| A | THR91 | |
| A | ARG96 | |
| A | SER142 | |
| A | THR143 | |
| A | GLU193 | |
| B | PRO89 | |
| B | THR91 | |
| B | ARG96 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ARG64 | |
| A | ARG148 | |
| A | LYS240 | |
| B | ARG64 | |
| B | ARG148 | |
| B | LYS240 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405 |
| Chain | Residue | Details |
| A | ILE121 | |
| B | ILE121 | |
| Chain | Residue | Details |
| A | SER150 | |
| B | SER150 | |
| Chain | Residue | Details |
| A | SER184 | |
| B | SER184 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN3 | |
| B | ASN3 | |
