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PDB: 20 件
3L9Q
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Crystal structure of human polymerase alpha-primase p58 iron-sulfur cluster domain
分子名称: DNA primase large subunit, IRON/SULFUR CLUSTER, SULFATE ION
著者Vaithiyalingam, S, Eichman, B.F, Chazin, W.J.
登録日2010-01-05
公開日2010-07-14
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.
Proc.Natl.Acad.Sci.USA, 107, 2010
5I7M
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BU of 5i7m by Molmil
Crystal structure of Y345F mutant of human primase p58 iron-sulfur cluster domain
分子名称: DNA primase large subunit, IRON/SULFUR CLUSTER, SULFATE ION
著者Salay, L.E, Thompson, M.K, Chazin, W.J.
登録日2016-02-17
公開日2017-03-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Science, 355, 2017
6DHW
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BU of 6dhw by Molmil
Crystal structure of primase iron-sulfur domain (266-457)
分子名称: DNA primase large subunit, IRON/SULFUR CLUSTER, SULFATE ION
著者Holt, M.E, Salay, L.E, Chazin, W.J.
登録日2018-05-21
公開日2018-12-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.013 Å)
主引用文献Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs.
PLoS ONE, 13, 2018
5F0Q
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Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer
分子名称: DNA (5'-D(*GP*CP*CP*GP*CP*CP*AP*AP*CP*AP*TP*A)-3'), DNA primase large subunit, IRON/SULFUR CLUSTER, ...
著者Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
登録日2015-11-28
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J.Biol.Chem., 291, 2016
5DQO
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BU of 5dqo by Molmil
Crystal structure of Y347F mutant of human primase p58 iron-sulfur cluster domain
分子名称: DNA primase large subunit, IRON/SULFUR CLUSTER
著者Salay, L.E, Thompson, M.K, Chazin, W.J.
登録日2015-09-15
公開日2016-09-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Science, 355, 2017
3Q36
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BU of 3q36 by Molmil
Crystal structure of the 4Fe-4S cluster domain of human DNA primase large subunit
分子名称: DNA primase large subunit, FE (III) ION, IRON/SULFUR CLUSTER
著者Agarkar, V.B, Babayeva, N.D, Tahirov, T.H.
登録日2010-12-21
公開日2011-04-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase - polymerase alpha switch.
Cell Cycle, 10, 2011
4RR2
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Crystal structure of human primase
分子名称: DNA primase large subunit, DNA primase small subunit, IRON/SULFUR CLUSTER, ...
著者Baranovskiy, A.G, Gu, J, Suwa, Y, Babayeva, N.D, Tahirov, T.H.
登録日2014-11-05
公開日2015-01-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Crystal structure of the human primase.
J.Biol.Chem., 290, 2015
4BPU
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Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain.
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
5F0S
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BU of 5f0s by Molmil
Crystal structure of C-terminal domain of the human DNA primase large subunit with bound DNA template/RNA primer and manganese ion
分子名称: DNA (5'-D(*GP*CP*CP*GP*CP*CP*AP*AP*CP*AP*TP*A)-3'), DNA primase large subunit, IRON/SULFUR CLUSTER, ...
著者Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
登録日2015-11-28
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J.Biol.Chem., 291, 2016
4BPW
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Crystal structure of human primase bound to UTP
分子名称: DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, MAGNESIUM ION, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
8QJ7
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BU of 8qj7 by Molmil
Cryo-EM structure of human DNA polymerase alpha-primase in pre-initiation stage 1
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, ...
著者Yin, Z, Pellegrini, L.
登録日2023-09-12
公開日2024-02-21
最終更新日2024-05-01
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献CryoEM insights into RNA primer synthesis by the human primosome.
Febs J., 291, 2024
8D96
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Human DNA polymerase alpha/primase elongation complex I bound to primer/template
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ...
著者He, Q, Baranovskiy, A, Lim, C, Tahirov, T.
登録日2022-06-09
公開日2023-04-19
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
4BPX
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BU of 4bpx by Molmil
Crystal structure of human primase in complex with the primase- binding motif of DNA polymerase alpha
分子名称: DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, ...
著者Kilkenny, M.L, Perera, R.L, Pellegrini, L.
登録日2013-05-28
公開日2013-09-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
Proc.Natl.Acad.Sci.USA, 110, 2013
8B9D
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BU of 8b9d by Molmil
Human replisome bound by Pol Alpha
分子名称: Cell division control protein 45 homolog, Claspin, DNA Molecule, ...
著者Jones, M.L, Yeeles, J.T.P.
登録日2022-10-05
公開日2023-08-09
最終更新日2023-08-30
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication.
Mol.Cell, 83, 2023
8D0B
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BU of 8d0b by Molmil
Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template
分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
著者He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C.
登録日2022-05-26
公開日2022-06-22
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
8D9D
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BU of 8d9d by Molmil
Human DNA polymerase-alpha/primase elongation complex II bound to primer/template
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*GP*GP*TP*CP*GP*TP*GP*CP*CP*GP*CP*CP*AP*AP*TP*AP*A)-3'), DNA polymerase alpha catalytic subunit, ...
著者He, Q, Baranovskiy, A, Lim, C, Tahirov, T.
登録日2022-06-09
公開日2023-04-19
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Structures of human primosome elongation complexes.
Nat.Struct.Mol.Biol., 30, 2023
5EXR
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BU of 5exr by Molmil
Crystal structure of human primosome
分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
著者Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
登録日2015-11-24
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome.
J.Biol.Chem., 291, 2016
7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
分子名称: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
著者Kilkenny, M.L, Pellegrini, L.
登録日2021-06-01
公開日2021-11-10
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.12 Å)
主引用文献Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
8D0K
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BU of 8d0k by Molmil
Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC
分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
著者He, Q, Lin, X, Chavez, B.L, Agrawal, S, Lusk, B.L, Lim, C.
登録日2022-05-26
公開日2022-06-22
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (4.27 Å)
主引用文献Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Nature, 608, 2022
7U5C
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BU of 7u5c by Molmil
Cryo-EM structure of human CST bound to DNA polymerase alpha-primase in a recruitment state
分子名称: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ...
著者Cai, S.W, Zinder, J.C, Svetlov, V, Bush, M.W, Nudler, E, Walz, T, de Lange, T.
登録日2022-03-02
公開日2022-05-18
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Cryo-EM structure of the human CST-Pol alpha /primase complex in a recruitment state.
Nat.Struct.Mol.Biol., 29, 2022

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件を2024-08-07に公開中

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