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PDB: 17 件
5HHY
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BU of 5hhy by Molmil
Structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) showing X-Ray induced reduction of PLP internal aldimine to 4'-deoxy-piridoxine-phosphate (PLR)
分子名称: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
登録日2016-01-11
公開日2017-01-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5F9S
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BU of 5f9s by Molmil
Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.7 Angstrom; internal aldimine with PLP in the active site
分子名称: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
登録日2015-12-10
公開日2016-12-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
5LUC
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BU of 5luc by Molmil
Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 1.8 Angstrom; internal aldimine with PLP in the active site
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Cellini, B, Borri Voltattorni, C, Montioli, R.
登録日2016-09-08
公開日2017-09-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
2YOB
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BU of 2yob by Molmil
High resolution AGXT_M structure
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ...
著者Fabelo-Rosa, I, Mesa-Torres, N, Riverol, D, Yunta, C, Albert, A, Salido, E, Pey, A.L.
登録日2012-10-22
公開日2013-10-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The Role of Protein Denaturation Energetics and Molecular Chaperones in the Aggregation and Mistargeting of Mutants Causing Primary Hyperoxaluria Type I
Plos One, 8, 2013
4KYO
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BU of 4kyo by Molmil
Alanine-glyoxylate aminotransferase variant K390A in complex with the TPR domain of human Pex5p
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, ...
著者Fodor, K, Lou, Y, Wilmanns, M.
登録日2013-05-29
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
7NS7
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BU of 7ns7 by Molmil
Human L-alanine:glyoxylate aminotransferase minor allele variant: AGXT-Mi (P11L-I340M)
分子名称: L-alanine:glyoxylate aminotransferase
著者Cellini, B, Dindo, M.
登録日2021-03-05
公開日2022-03-23
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural dynamics shape the fitness window of alanine:glyoxylate aminotransferase.
Protein Sci., 31, 2022
4CBS
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BU of 4cbs by Molmil
X-ray structure of quintuple mutant of human alanine glyoxylate aminotransferase, AGXT_RHEAM
分子名称: PYRIDOXAL-5'-PHOSPHATE, SERINE--PYRUVATE AMINOTRANSFERASE
著者Yunta, C, Albert, A.
登録日2013-10-16
公開日2014-07-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Consensus-Based Approach for Gene/Enzyme Replacement Therapies and Crystallization Strategies: The Case of Human Alanine:Glyoxylate Aminotransferase.
Biochem.J., 462, 2014
4CBR
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BU of 4cbr by Molmil
X-ray structure of the more stable human AGXT triple mutant (AGXT_HEM)
分子名称: GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, SERINE--PYRUVATE AMINOTRANSFERASE
著者Yunta, C, Albert, A.
登録日2013-10-16
公開日2014-07-09
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Consensus-Based Approach for Gene/Enzyme Replacement Therapies and Crystallization Strategies: The Case of Human Alanine:Glyoxylate Aminotransferase.
Biochem.J., 462, 2014
3R9A
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BU of 3r9a by Molmil
Human alanine-glyoxylate aminotransferase in complex with the TPR domain of human PEX5P
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Peroxisomal targeting signal 1 receptor, Serine--pyruvate aminotransferase
著者Fodor, K, Wilmanns, M.
登録日2011-03-25
公開日2011-05-11
最終更新日2012-05-02
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1
Plos Biol., 10, 2012
5OG0
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BU of 5og0 by Molmil
Crystal structure of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at 2.5 Angstrom; internal aldimine with PLP in the active site
分子名称: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
登録日2017-07-11
公開日2017-09-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
1H0C
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BU of 1h0c by Molmil
The crystal structure of human alanine:glyoxylate aminotransferase
分子名称: (AMINOOXY)ACETIC ACID, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE, ...
著者Zhang, X, Danpure, C.J, Roe, S.M, Pearl, L.H.
登録日2002-06-17
公開日2003-06-12
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1.
J.Mol.Biol., 331, 2003
1J04
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BU of 1j04 by Molmil
Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro
分子名称: (AMINOOXY)ACETIC ACID, GLYCEROL, alanine--glyoxylate aminotransferase
著者Zhang, X, Djordjevic, S, Bartlam, M, Ye, S, Rao, Z, Danpure, C.J.
登録日2002-10-30
公開日2003-11-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting.
Acta Crystallogr.,Sect.F, 66, 2010
6RV0
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BU of 6rv0 by Molmil
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma); with PMP in the active site
分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D.
登録日2019-05-30
公開日2020-04-08
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019
5OFY
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BU of 5ofy by Molmil
Crystal structure of the D183N variant of human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) at pH 9.0. 2.8 Ang; internal aldimine with PLP in the active site
分子名称: 1,4-DIETHYLENE DIOXIDE, PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Borri Voltattorni, C, Cellini, B, Montioli, R.
登録日2017-07-11
公開日2017-09-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis.
Sci Rep, 7, 2017
4KXK
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BU of 4kxk by Molmil
Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p
分子名称: BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, SULFATE ION, ...
著者Fodor, K, Lou, Y, Wilmanns, M.
登録日2013-05-27
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
4I8A
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BU of 4i8a by Molmil
Alanine-glyoxylate aminotransferase variant S187F
分子名称: GLYCEROL, Serine-pyruvate aminotransferase
著者Fodor, K, Oppici, E, Williams, C, Cellini, B, Wilmanns, M.
登録日2012-12-03
公開日2013-05-01
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications.
Proteins, 81, 2013
6RV1
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BU of 6rv1 by Molmil
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma)
分子名称: PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase
著者Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D.
登録日2019-05-30
公開日2020-04-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Biochem.J., 476, 2019

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件を2024-07-31に公開中

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