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3R9A

Human alanine-glyoxylate aminotransferase in complex with the TPR domain of human PEX5P

Replaces:  3IMZ
Summary for 3R9A
Entry DOI10.2210/pdb3r9a/pdb
DescriptorSerine--pyruvate aminotransferase, Peroxisomal targeting signal 1 receptor, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywordstpr-domain, protein-protein complex, peroxisome, aminotransf pyruvate, transferase, disease mutation, membrane, peroxiso biogenesis disorder, protein transport, tpr repeat, transpo zellweger syndrome, transferase-transport protein complex, mitochondrion, pyridoxal phosphate, transferase/transport protein
Biological sourceHomo sapiens (human)
More
Cellular locationPeroxisome: P21549
Cytoplasm: P50542
Total number of polymer chains4
Total formula weight159308.73
Authors
Fodor, K.,Wilmanns, M. (deposition date: 2011-03-25, release date: 2011-05-11, Last modification date: 2012-05-02)
Primary citationFodor, K.,Wolf, J.,Erdmann, R.,Schliebs, W.,Wilmanns, M.
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1
Plos Biol., 10:e1001309-e1001309, 2012
Cited by
PubMed: 22529745
DOI: 10.1371/journal.pbio.1001309
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

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