3QYL
 
 | | Sensitivity of receptor internal motions to ligand binding affinity and kinetic off-rate | | 分子名称: | (7S)-7-methyl-5,6,7,8-tetrahydroquinazoline-2,4-diamine, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Collins, E.J, Lee, A.L, Carroll, M.J, Mauldin, R.V, Gromova, A.V, Singleton, S.F. | | 登録日 | 2011-03-03 | | 公開日 | 2012-01-18 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Evidence for dynamics in proteins as a mechanism for ligand dissociation.
Nat.Chem.Biol., 8, 2012
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3OCH
 | | Chemically Self-assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic | | 分子名称: | (2S,2'S)-5,5'-(nonane-1,9-diyldiimino)bis(2-{[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]amino}-5-oxopentanoic acid) (non-preferred name), CHLORIDE ION, Dihydrofolate reductase, ... | | 著者 | Cody, V. | | 登録日 | 2010-08-10 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic.
J.Am.Chem.Soc., 132, 2010
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5E8Q
 | |
3QL3
 | | Re-refined coordinates for PDB entry 1RX2 | | 分子名称: | Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... | | 著者 | Bhabha, G, Ekiert, D.C, Wright, P.E, Wilson, I.A. | | 登録日 | 2011-02-02 | | 公開日 | 2011-04-27 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.
Science, 332, 2011
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1RA3
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1RA8
 | |
4X5I
 | | ecDHFR complexed with folate and NADP+ at 660 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Yamada, H, Watanabe, N, Nagae, T. | | 登録日 | 2014-12-05 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
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1RX2
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1DHJ
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1RF7
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5UJX
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5Z6F
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5Z6K
 | |
5Z6J
 | |
4X5J
 | | ecDHFR complexed with folate and NADP+ at 750 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Yamada, H, Watanabe, N, Nagae, T. | | 登録日 | 2014-12-05 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
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1DYJ
 | | ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS | | 分子名称: | 5,10-DIDEAZATETRAHYDROFOLIC ACID, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Reyes, V.M, Kraut, J. | | 登録日 | 1994-10-26 | | 公開日 | 1995-06-03 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.
Biochemistry, 34, 1995
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4GH8
 | | Crystal structure of a 'humanized' E. coli dihydrofolate reductase | | 分子名称: | CALCIUM ION, Dihydrofolate reductase, METHOTREXATE, ... | | 著者 | French, J.B, Liu, C.T, Hanoian, P, Pringle, T.H, Hammes-Schiffer, S, Benkovic, S.J. | | 登録日 | 2012-08-07 | | 公開日 | 2013-06-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4I1N
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1DRA
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4X5H
 | | ecDHFR complexed with folate and NADP+ at 500 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Yamada, H, Watanabe, N, Nagae, T. | | 登録日 | 2014-12-05 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
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1RA1
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4X5G
 | | ecDHFR complexed with folate and NADP+ at 270 MPa | | 分子名称: | BETA-MERCAPTOETHANOL, Dihydrofolate reductase, FOLIC ACID, ... | | 著者 | Yamada, H, Watanabe, N, Nagae, T. | | 登録日 | 2014-12-05 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | High-pressure protein crystal structure analysis of Escherichia coli dihydrofolate reductase complexed with folate and NADP.
Acta Crystallogr D Struct Biol, 74, 2018
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6XG5
 | | X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim | | 分子名称: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | | 著者 | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | | 登録日 | 2020-06-16 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A trimethoprim derivative impedes antibiotic resistance evolution.
Nat Commun, 12, 2021
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2DRC
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1RX9
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