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PDB: 62 件
3CSU
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CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE
分子名称: CALCIUM ION, PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE)
著者Beernink, P.T, Endrizzi, J.A, Alber, T, Schachman, H.K.
登録日1999-04-22
公開日1999-05-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit.
Proc.Natl.Acad.Sci.USA, 96, 1999
4FYY
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E. coli Aspartate Transcarbamoylase Complexed with CTP, UTP, and Mg2+
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Cockrell, G.M, Kantrowitz, E.R.
登録日2012-07-05
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.9395 Å)
主引用文献Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 51, 2012
1EKX
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THE ISOLATED, UNREGULATED CATALYTIC TRIMER OF ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH BISUBSTRATE ANALOG PALA (N-(PHOSPHONACETYL)-L-ASPARTATE)
分子名称: ASPARTATE TRANSCARBAMOYLASE, CALCIUM ION, N-(PHOSPHONACETYL)-L-ASPARTIC ACID
著者Endrizzi, J.A, Beernink, P.T, Alber, T, Schachman, H.K.
登録日2000-03-09
公開日2000-05-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation induced cell migration.
Proc.Natl.Acad.Sci.USA, 97, 2000
2AIR
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BU of 2air by Molmil
T-state Active Site of Aspartate Transcarbamylase:Crystal Structure of the Carbamyl Phosphate and L-alanosine Ligated Enzyme
分子名称: 3-[HYDROXY(NITROSO)AMINO]-L-ALANINE, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
著者Huang, J, Lipscomb, W.N.
登録日2005-07-30
公開日2006-01-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献T-State Active Site of Aspartate Transcarbamylase: Crystal Structure of the Carbamyl Phosphate and l-Alanosine Ligated Enzyme
Biochemistry, 45, 2006
6KJB
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wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167
分子名称: Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Wang, N, Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-06-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation.
Int J Mol Sci, 21, 2020
4FYX
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E. coli Aspartate Transcarbamoylase complexed with dCTP, UTP, and Mg2+
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
著者Cockrell, G.M, Kantrowitz, E.R.
登録日2012-07-05
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.0889 Å)
主引用文献Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 51, 2012
4FYV
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Aspartate Transcarbamoylase Complexed with dCTP
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
著者Cockrell, G.M, Kantrowitz, E.R.
登録日2012-07-05
公開日2012-10-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.0976 Å)
主引用文献Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 51, 2012
1D09
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ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH N-PHOSPHONACETYL-L-ASPARTATE (PALA)
分子名称: ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
著者Jin, L, Stec, B, Lipscomb, W.N, Kantrowitz, E.R.
登録日1999-09-09
公開日2000-01-28
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Insights into the mechanisms of catalysis and heterotropic regulation of Escherichia coli aspartate transcarbamoylase based upon a structure of the enzyme complexed with the bisubstrate analogue N-phosphonacetyl-L-aspartate at 2.1 A.
Proteins, 37, 1999
3NPM
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BU of 3npm by Molmil
Crystal Structure of the C47A/A241C disulfide-linked C6 Aspartate Transcarbamoylase enzyme
分子名称: Aspartate carbamoyltransferase catalytic chain, PHOSPHATE ION
著者Mendes, K.R, Kantrowitz, E.R.
登録日2010-06-28
公開日2011-05-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A cooperative Escherichia coli aspartate transcarbamoylase without regulatory subunits .
Biochemistry, 49, 2010
1TUG
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Aspartate Transcarbamoylase Catalytic Chain Mutant E50A Complex with Phosphonoacetamide, Malonate, and Cytidine-5-Prime-Triphosphate (CTP)
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Stieglitz, K, Stec, B, Baker, D.P, Kantrowitz, E.R.
登録日2004-06-24
公開日2004-07-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Monitoring the Transition from the T to the R State in E.coli Aspartate Transcarbamoylase by X-ray Crystallography: Crystal Structures of the E50A Mutant Enzyme in Four Distinct Allosteric States.
J.Mol.Biol., 341, 2004
2FZC
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BU of 2fzc by Molmil
The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R.
登録日2006-02-09
公開日2006-08-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.
Biochemistry, 45, 2006
4FYW
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BU of 4fyw by Molmil
E. coli Aspartate Transcarbamoylase complexed with CTP
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Cockrell, G.M, Kantrowitz, E.R.
登録日2012-07-05
公開日2012-10-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Metal Ion Involvement in the Allosteric Mechanism of Escherichia coli Aspartate Transcarbamoylase.
Biochemistry, 51, 2012
2QGF
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Structure of regulatory chain mutant H20A of asparate transcarbamoylase from E. coli
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Stec, B, Williams, M.K, Stieglitz, K.A, Kantrowitz, E.R.
登録日2007-06-28
公開日2008-02-19
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors.
Acta Crystallogr.,Sect.D, 63, 2007
1ZA1
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Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP at 2.20 A resolution
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Wang, J, Stieglitz, K.A, Cardia, J.P, Kantrowitz, E.R.
登録日2005-04-05
公開日2005-06-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase
Proc.Natl.Acad.Sci.Usa, 102, 2005
2FZG
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BU of 2fzg by Molmil
The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.25 Resolution
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R.
登録日2006-02-09
公開日2006-08-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition.
Biochemistry, 45, 2006
1F1B
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BU of 1f1b by Molmil
CRYSTAL STRUCTURE OF E. COLI ASPARTATE TRANSCARBAMOYLASE P268A MUTANT IN THE R-STATE IN THE PRESENCE OF N-PHOSPHONACETYL-L-ASPARTATE
分子名称: ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN, ASPARTATE CARBAMOYLTRANSFERASE REGULATORY CHAIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
著者Jin, L, Stec, B, Kantrowitz, E.R.
登録日2000-05-18
公開日2000-11-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A cis-proline to alanine mutant of E. coli aspartate transcarbamoylase: kinetic studies and three-dimensional crystal structures.
Biochemistry, 39, 2000
2H3E
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Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of N-phosphonacetyl-L-isoasparagine at 2.3A resolution
分子名称: (S)-4-AMINO-4-OXO-3-(2-PHOSPHONOACETAMIDO)BUTANOIC ACID, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ...
著者Eldo, J, Cardia, J.P, O'Day, E.M, Xia, J, Tsuruta, H, Kantrowitz, E.R.
登録日2006-05-22
公開日2006-10-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献N-Phosphonacetyl-l-isoasparagine a Potent and Specific Inhibitor of Escherichia coli Aspartate Transcarbamoylase.
J.Med.Chem., 49, 2006
4F04
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A Second Allosteric site in E. coli Aspartate Transcarbamoylase: R-state ATCase with UTP bound
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
著者Peterson, A.W, Cockrell, G.M, Kantrowitz, E.R.
登録日2012-05-03
公開日2012-07-11
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A second allosteric site in Escherichia coli aspartate transcarbamoylase.
Biochemistry, 51, 2012
1R0C
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Products in the T State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-carbamyl-L-aspartate Ligated Enzyme
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-CARBAMOYL-L-ASPARTATE, ...
著者Huang, J, Lipscomb, W.N.
登録日2003-09-19
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Products in the T-State of Aspartate Transcarbamylase: Crystal Structure of the Phosphate and N-Carbamyl-l-aspartate Ligated Enzyme
Biochemistry, 43, 2004
9ATC
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ATCASE Y165F MUTANT
分子名称: ASPARTATE TRANSCARBAMOYLASE, ZINC ION
著者Ha, Y, Allewell, N.M.
登録日1998-06-26
公開日1999-07-26
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Intersubunit hydrogen bond acts as a global molecular switch in Escherichia coli aspartate transcarbamoylase.
Proteins, 33, 1998
1Q95
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Aspartate Transcarbamylase (ATCase) of Escherichia coli: A New Crystalline R State Bound to PALA, or to Product Analogues Phosphate and Citrate
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, ...
著者Huang, J, Lipscomb, W.N.
登録日2003-08-22
公開日2004-06-08
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Aspartate Transcarbamylase (ATCase) of Escherichia coli: A New Crystalline R-State Bound to PALA, or to Product Analogues Citrate and Phosphate
Biochemistry, 43, 2004
1ZA2
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Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of CTP, carbamoyl phosphate at 2.50 A resolution
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Wang, J, Stieglitz, K.A, Cardia, J.P, Kantrowitz, E.R.
登録日2005-04-05
公開日2005-06-07
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for ordered substrate binding and cooperativity in aspartate transcarbamoylase
Proc.Natl.Acad.Sci.Usa, 102, 2005
6KJ9
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E. coli ATCase catalytic subunit mutant - G128/130A
分子名称: Aspartate carbamoyltransferase catalytic subunit
著者Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-03-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development.
Febs J., 287, 2020
1RAD
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BU of 1rad by Molmil
CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
登録日1992-08-14
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993
1RAG
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CRYSTAL STRUCTURE OF CTP-LIGATED T STATE ASPARTATE TRANSCARBAMOYLASE AT 2.5 ANGSTROMS RESOLUTION: IMPLICATIONS FOR ATCASE MUTANTS AND THE MECHANISM OF NEGATIVE COOPERATIVITY
分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ...
著者Kosman, R.P, Gouaux, J.E, Lipscomb, W.N.
登録日1992-08-14
公開日1994-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of CTP-ligated T state aspartate transcarbamoylase at 2.5 A resolution: implications for ATCase mutants and the mechanism of negative cooperativity.
Proteins, 15, 1993

 

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