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PDB: 12 件
8Y6H
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BU of 8y6h by Molmil
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
分子名称: ATP-dependent translocase ABCB1,mNeonGreen, UIC2 Fab heavy chain, UIC2 Fab light chain, ...
著者Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T.
登録日2024-02-02
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.49 Å)
主引用文献Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
8Y6I
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BU of 8y6i by Molmil
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, ATP-dependent translocase ABCB1,mNeonGreen, CHOLESTEROL, ...
著者Hamaguchi-Suzuki, N, Adachi, N, Moriya, T, Kawasaki, M, Suzuki, K, Anzai, N, Senda, T, Murata, T.
登録日2024-02-02
公開日2024-04-17
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献Cryo-EM structure of P-glycoprotein bound to triple elacridar inhibitor molecules.
Biochem.Biophys.Res.Commun., 709, 2024
7A69
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BU of 7a69 by Molmil
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and vincristine
分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2020-08-25
公開日2020-10-21
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
6C0V
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BU of 6c0v by Molmil
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance protein 1
著者Kim, Y.J, Chen, J.
登録日2018-01-02
公開日2018-01-31
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.
Science, 359, 2018
7A6F
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BU of 7a6f by Molmil
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and zosuquidar
分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2020-08-25
公開日2020-10-14
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
7O9W
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BU of 7o9w by Molmil
Encequidar-bound human P-glycoprotein in complex with UIC2-Fab
分子名称: Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2021-04-17
公開日2022-01-12
最終更新日2022-01-26
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations.
J.Med.Chem., 65, 2022
6FN1
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BU of 6fn1 by Molmil
Zosuquidar and UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Human-mouse chimeric ABCB1 (ABCBHM), UIC2 Antigen Binding Fragment Heavy Chain, ...
著者Alam, A, Locher, K.P.
登録日2018-02-02
公開日2018-02-21
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6QEX
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BU of 6qex by Molmil
Nanodisc reconstituted human ABCB1 in complex with UIC2 fab and taxol
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Alam, A, Locher, K.P.
登録日2019-01-08
公開日2019-02-27
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structural insight into substrate and inhibitor discrimination by human P-glycoprotein.
Science, 363, 2019
7A6E
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BU of 7a6e by Molmil
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and tariquidar
分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2020-08-25
公開日2020-10-14
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
7A6C
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BU of 7a6c by Molmil
Nanodisc reconstituted human ABCB1 in complex with MRK16 Fab and elacridar
分子名称: CHOLESTEROL, If kappa light chain, MRK16 Fab-fragment heavy chain, ...
著者Nosol, K, Locher, K.P.
登録日2020-08-25
公開日2020-10-14
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
7A65
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BU of 7a65 by Molmil
Nanodisc reconstituted, drug-free human ABCB1 in complex with MRK16 Fab
分子名称: CHOLESTEROL, MRK16 Fab-fragment heavy chain, MRK16 Fab-fragment light chain, ...
著者Nosol, K, Locher, K.P.
登録日2020-08-25
公開日2020-10-14
最終更新日2020-10-28
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1.
Proc.Natl.Acad.Sci.USA, 117, 2020
6FN4
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BU of 6fn4 by Molmil
Apo form of UIC2 Fab complex of human-mouse chimeric ABCB1 (ABCB1HM)
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Apo form of Human-mouse chimeric ABCB1 (ABCB1HM) in complex with Antigen binding fragment of UIC2., ...
著者Alam, A, Locher, K.P.
登録日2018-02-02
公開日2018-02-21
最終更新日2021-06-02
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018

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件を2024-07-10に公開中

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