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PDB: 19 件
8B4T
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Human cathepsin B in complex with the carbamate inhibitor 7
分子名称: (2S)-2-[[(2S)-2-[(4-chloranylphenoxy)carbonylamino]-3-cyclohexyl-propanoyl]amino]-3-phenyl-propanoic acid, Cathepsin B
著者Rubesova, P, Guetschow, M, Mares, M.
登録日2022-09-21
公開日2023-10-04
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Human cathepsin B in complex with the carbamate inhibitor 7
To Be Published
8HEI
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Crystal structure of CTSB in complex with E64d
分子名称: Cathepsin B, GLYCEROL, ethyl (3S)-3-hydroxy-4-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}amino)-4-oxobutanoate
著者Wang, H, Li, D, Sun, L, Yang, H.
登録日2022-11-08
公開日2023-12-13
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.
Nat Commun, 14, 2023
8HE9
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Crystal structure of CTSB in complex with K777
分子名称: Cathepsin B, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者Wang, H, Li, D, Sun, L, Yang, H.
登録日2022-11-07
公開日2023-12-13
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.
Nat Commun, 14, 2023
6AY2
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Structure of CathB with covalently linked Compound 28
分子名称: Cathepsin B, N~1~-[(2S)-1-amino-5-(carbamoylamino)pentan-2-yl]-N'~1~-[(1R)-1-(thiophen-3-yl)ethyl]cyclobutane-1,1-dicarboxamide
著者Kiefer, J.R, Steinbacher, S.
登録日2017-09-07
公開日2017-12-27
最終更新日2018-02-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
J. Med. Chem., 61, 2018
8B5F
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Human cathepsin B in complex with the carbamate inhibitor 31
分子名称: (2S)-2-[[(2S)-2-[[3-chloranyl-4-[[3-phenyl-2-(phenylmethyl)propanoyl]amino]phenoxy]carbonylamino]-3-cyclohexyl-propanoyl]amino]-3-phenyl-propanoic acid, 1,2-ETHANEDIOL, Cathepsin B
著者Rubesova, P, Guetschow, M, Mares, M.
登録日2022-09-22
公開日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Human cathepsin B in complex with the carbamate inhibitor 31
To Be Published
3CBJ
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Chagasin-Cathepsin B complex
分子名称: Cathepsin B, Chagasin, PHOSPHATE ION
著者Redzynia, I, Bujacz, G.D, Abrahamson, M, Ljunggren, A, Jaskolski, M, Mort, J.S.
登録日2008-02-22
公開日2008-05-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B.
J.Biol.Chem., 283, 2008
5MBL
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Cathepsin B in complex with DARPin 81
分子名称: Cathepsin B, DARPin 81, SULFATE ION
著者Turk, D, Kramer, L, Renko, M, Turk, B.
登録日2016-11-08
公開日2017-12-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Cathepsin B in complex with DARPin 81
To Be Published
1GMY
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Cathepsin B complexed with dipeptidyl nitrile inhibitor
分子名称: 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, CATHEPSIN B, ...
著者Greenspan, P.D, Clark, K.L, Tommasi, R.A, Cowen, S.D, McQuire, L.W, Farley, D.L, van Duzer, J.H, Goldberg, R.L, Zhou, H, Du, Z, Fitt, J.J, Coppa, D.E, Fang, Z, Macchia, W, Zhu, L, Capparelli, M.P, Goldstein, R, Wigg, A.M, Doughty, J.R, Bohacek, R.S, Knap, A.K.
登録日2001-09-25
公開日2002-09-19
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design
J.Med.Chem., 44, 2001
8HEN
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Crystal structure of CTSB in complex with 212-148
分子名称: 2-[4-[[(2~{S})-1-oxidanylidene-3-phenyl-1-[[(3~{S})-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]amino]propan-2-yl]carbamoyl]piperazin-1-yl]ethyl 4-carbamimidamidobenzoate, Cathepsin B, DIMETHYL SULFOXIDE, ...
著者Wang, H, Li, D, Sun, L, Yang, H.
登録日2022-11-08
公開日2023-12-13
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry.
Nat Commun, 14, 2023
1CSB
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Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors
分子名称: CATHEPSIN B heavy chain, CATHEPSIN B light chain, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-isoleucyl-L-proline
著者Turk, D, Bode, W.
登録日1994-12-09
公開日1996-04-03
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.
Biochemistry, 34, 1995
1HUC
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THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY
分子名称: CATHEPSIN B
著者Musil, D, Bode, W.
登録日1993-04-21
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity.
EMBO J., 10, 1991
3AI8
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Cathepsin B in complex with the nitroxoline
分子名称: 5-nitroquinolin-8-ol, Cathepsin B
著者Renko, M, Mirkovic, B, Gobec, S, Kos, J, Turk, D.
登録日2010-05-11
公開日2011-05-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
Chemmedchem, 6, 2011
2IPP
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Crystal Structure of the tetragonal form of human liver cathepsin B
分子名称: 2-PYRIDINETHIOL, Cathepsin B
著者Huber, C.P, Campbell, R.L, Hasnain, S, Hirama, T, To, R.
登録日2006-10-12
公開日2006-12-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal Structure of the tetragonal form of human liver cathepsin B
To be Published
3PBH
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REFINED CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 2.5 ANGSTROM RESOLUTION
分子名称: PROCATHEPSIN B
著者Podobnik, M, Turk, D, Kuhelj, R, Turk, V.
登録日1997-02-13
公開日1998-02-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen.
J.Mol.Biol., 271, 1997
3K9M
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Cathepsin B in complex with stefin A
分子名称: Cathepsin B, Cystatin-A
著者Renko, M, Turk, D.
登録日2009-10-16
公開日2009-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft
Febs J., 277, 2010
3CBK
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chagasin-cathepsin B
分子名称: Cathepsin B, Chagasin
著者Redzynia, I, Bujacz, G.D, Abrahamson, M, Ljunggren, A, Jaskolski, M, Mort, J.S.
登録日2008-02-22
公開日2008-05-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B.
J.Biol.Chem., 283, 2008
5MBM
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Cathepsin B in complex with DARPin 8h6
分子名称: Cathepsin B, DARPin 8h6
著者Turk, D, Kramer, L, Renko, M, Turk, B.
登録日2016-11-08
公開日2017-12-20
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Cathepsin B in complex with DARPin 8h6
To Be Published
1PBH
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CRYSTAL STRUCTURE OF HUMAN RECOMBINANT PROCATHEPSIN B AT 3.2 ANGSTROM RESOLUTION
分子名称: PROCATHEPSIN B
著者Podobnik, M, Turk, D.
登録日1997-02-14
公開日1998-02-25
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.
FEBS Lett., 384, 1996
2PBH
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CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION
分子名称: PROCATHEPSIN B
著者Podobnik, M, Turk, D, Kuhelj, R, Turk, V.
登録日1997-02-14
公開日1998-02-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide.
FEBS Lett., 384, 1996

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