3K9M

Cathepsin B in complex with stefin A

Summary for 3K9M

• Entry DOI: 10.2210/pdb3k9m/pdb
• Related: 1NB3 1STF
• Descriptor: Cathepsin B, Cystatin-A (3 entities in total)
• Functional Keywords: disulfide bond, glycoprotein, lysosome, protease, thiol protease, zymogen, thiol protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Lysosome : P07858; Cytoplasm : P01040
• Total number of polymer chains: 4
• Total formula weight: 77726.88

Authors

Renko, M.,Turk, D. (deposition date: 2009-10-16, release date: 2009-11-03, Last modification date: 2023-11-01)

• Primary citation: Renko, M.,Pozgan, U.,Majera, D.,Turk, D.; Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft; Febs J., 277:4338-4345, 2010; PubMed: 20860624; DOI: 10.1111/j.1742-4658.2010.07824.x

Experimental method

X-RAY DIFFRACTION (2.61 Å)