3CBK

chagasin-cathepsin B

Summary for 3CBK

Entry DOI	10.2210/pdb3cbk/pdb
Related	1HUC 2NNR 2NQD 3CBJ 3PBH
Descriptor	Cathepsin B, Chagasin (3 entities in total)
Functional Keywords	chagasin, cathepsin b, occluding loop, chagas disease, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen, cytoplasmic vesicle, protease inhibitor, thiol protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Lysosome : P07858 Flagellar pocket : Q966X9
Total number of polymer chains	2
Total formula weight	41366.10
Authors	Redzynia, I.,Bujacz, G.D.,Abrahamson, M.,Ljunggren, A.,Jaskolski, M.,Mort, J.S. (deposition date: 2008-02-22, release date: 2008-05-27, Last modification date: 2023-11-01)
Primary citation	Redzynia, I.,Ljunggren, A.,Abrahamson, M.,Mort, J.S.,Krupa, J.C.,Jaskolski, M.,Bujacz, G. Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B. J.Biol.Chem., 283:22815-22825, 2008 Cited by PubMed: 18515357 DOI: 10.1074/jbc.M802064200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.67 Å)

Structure validation