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PDB: 54 件
6RCR
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TETR(D) H100A MUTANT IN COMPLEX WITH DOXYCYCLINE AND MAGNESIUM
分子名称: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-04-11
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
3FK7
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Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc
分子名称: (4aS,12aS)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide, MAGNESIUM ION, Tetracycline repressor protein class B from transposon Tn10, ...
著者Klieber, M.A, Scholz, O, Lochner, S, Gmeiner, P, Hillen, W, Muller, Y.A.
登録日2008-12-16
公開日2009-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
6QJX
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TetR(D) T103A mutant in complex with minocycline and magnesium
分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-01-27
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
6QJW
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TetR(D) T103A mutant in complex with 7-chlortetracycline and magnesium
分子名称: 7-CHLOROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B.
登録日2019-01-27
公開日2019-08-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding.
Biochim Biophys Acta Proteins Proteom, 1868, 2020
2TCT
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BU of 2tct by Molmil
THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE
分子名称: 7-CHLOROTETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
著者Hinrichs, W, Kisker, C, Saenger, W.
登録日1995-03-02
公開日1996-04-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance.
J.Mol.Biol., 247, 1995
3FK6
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BU of 3fk6 by Molmil
Crystal structure of TetR triple mutant (H64K, S135L, S138I)
分子名称: Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D
著者Klieber, M.A, Scholz, O, Lochner, S, Gmeiner, P, Hillen, W, Muller, Y.A.
登録日2008-12-16
公開日2009-10-27
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair.
Febs J., 276, 2009
2XGE
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Crystal structure of a designed heterodimeric variant T-A(A)B of the tetracycline repressor
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, SODIUM ION, ...
著者Stiebritz, M.T, Wengrzik, S, Richter, J.P, Muller, Y.A.
登録日2010-06-03
公開日2010-09-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Computational Design of a Chain-Specific Tetracycline Repressor Heterodimer.
J.Mol.Biol., 403, 2010
2XGC
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Crystal structure of a designed heterodimeric variant T-A(I)B of the tetracycline repressor
分子名称: TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Stiebritz, M.T, Wengrzik, S, Richter, J.P, Muller, Y.A.
登録日2010-06-03
公開日2010-09-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Computational Design of a Chain-Specific Tetracycline Repressor Heterodimer.
J.Mol.Biol., 403, 2010
1BJZ
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TETRACYCLINE CHELATED MG2+-ION INITIATES HELIX UNWINDING FOR TET REPRESSOR INDUCTION
分子名称: TETRACYCLINE REPRESSOR
著者Orth, P, Saenger, W, Hinrichs, W.
登録日1998-06-29
公開日1999-01-13
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Tetracycline-chelated Mg2+ ion initiates helix unwinding in Tet repressor induction.
Biochemistry, 38, 1999
2FJ1
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Crystal Structure Analysis of Tet Repressor (class D) in Complex with 7-Chlortetracycline-Nickel(II)
分子名称: 7-CHLOROTETRACYCLINE, CHLORIDE ION, NICKEL (II) ION, ...
著者Orth, P, Saenger, W, Palm, G.J, Hinrichs, W.
登録日2005-12-30
公開日2007-01-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex.
J.Biol.Inorg.Chem., 13, 2008
4AUX
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BU of 4aux by Molmil
Tet repressor class D in complex with 9-nitrotetracycline
分子名称: (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-9-nitro-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, CHLORIDE ION, MAGNESIUM ION, ...
著者Orth, P, Saenger, W, Hinrichs, W.
登録日2012-05-22
公開日2012-05-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Tet Repressor Class D in Complex with 9-Nitrotetracycline and Magnesium
To be Published
2XGD
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BU of 2xgd by Molmil
Crystal structure of a designed homodimeric variant T-A(L)A(L) of the tetracycline repressor
分子名称: CHLORIDE ION, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Stiebritz, M.T, Wengrzik, S, Richter, J.P, Muller, Y.A.
登録日2010-06-03
公開日2010-09-22
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Computational Design of a Chain-Specific Tetracycline Repressor Heterodimer.
J.Mol.Biol., 403, 2010
6YR1
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BU of 6yr1 by Molmil
TetR(D) soaked with Tigecycline I4(1)22
分子名称: CHLORIDE ION, MAGNESIUM ION, TIGECYCLINE, ...
著者Hinrichs, W, Stary, K.
登録日2020-04-18
公開日2021-04-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献TetR(D) soaked with Tigecycline
to be published
2X6O
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BU of 2x6o by Molmil
Tet Repressor class D in complex with 7-chlor-2-cyano-iso- tetracycline
分子名称: (4S,4AS,6S,8AS)-6-[(1S)-7-CHLORO-4-HYDROXY-1-METHYL-3-OXO-1,3-DIHYDRO-2-BENZOFURAN-1-YL]-4-(DIMETHYLAMINO)-3,8A-DIHYDROXY-1,8-DIOXO-1,4,4A,5,6,7,8,8A-OCTAHYDRONAPHTHALENE-2-CARBONITRILE, CHLORIDE ION, TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Volkers, G, Hinrichs, W.
登録日2010-02-18
公開日2011-03-02
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor.
J.Med.Chem., 54, 2011
2X9D
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Tet repressor (class D) in complex with iso-7-chlortetracycline
分子名称: CHLORIDE ION, ISO-7-CHLORTETRACYCLINE, TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Volkers, G, Hinrichs, W.
登録日2010-03-15
公開日2011-03-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor.
J.Med.Chem., 54, 2011
4V2F
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Tetracycline repressor TetR(D), unliganded
分子名称: TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Werten, S, Orth, P, Saenger, W, Hinrichs, W.
登録日2014-10-09
公開日2014-12-10
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Tetracycline Repressor Allostery Does not Depend on Divalent Metal Recognition.
Biochemistry, 53, 2014
1A6I
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TET REPRESSOR, CLASS D VARIANT
分子名称: TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Orth, P, Cordes, F, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W.
登録日1998-02-25
公開日1999-03-02
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Conformational changes of the Tet repressor induced by tetracycline trapping.
J.Mol.Biol., 279, 1998
1ORK
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TET REPRESSOR, CLASS D IN COMPLEX WITH 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEMETHYL-6-DEOXY-TETRACYCLINE
分子名称: 9-(N,N-DIMETHYLGLYCYLAMIDO)-6-DEOXY-6-DEMETHYL-TETRACYCLINE, MAGNESIUM ION, TETRACYCLINE REPRESSOR
著者Orth, P, Schnappinger, D, Sum, P.-E, Ellestad, G.A, Hillen, W, Saenger, W, Hinrichs, W.
登録日1998-05-21
公開日1999-06-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)- 6-demethyl-6-deoxy-tetracycline.
J.Mol.Biol., 285, 1999
2NS7
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How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor
分子名称: Tetracycline repressor protein
著者Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A.
登録日2006-11-03
公開日2007-07-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
J.Mol.Biol., 368, 2007
3ZQG
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Structure of Tetracycline repressor in complex with antiinducer peptide-TAP2
分子名称: ANTI-INDUCER PEPTIDE TAP2, TETRACYCLINE REPRESSOR PROTEIN CLASS B FROM TRANSPOSON TN10, TETRACYCLINE REPRESSOR PROTEIN CLASS D
著者Sevvana, M, Goeke, D, Stoeckle, C, Kaspar, D, Grubmueller, S, Goetz, C, Wimmer, C, Berens, C, Klotzsche, M, Muller, Y.A, Hillen, W.
登録日2011-06-09
公開日2011-12-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献An Exclusive Alpha/Beta Code Directs Allostery in Tetr-Peptide Complexes.
J.Mol.Biol., 416, 2012
4AC0
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TETR(B) IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM
分子名称: (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Volkers, G, Hinrichs, W.
登録日2011-12-12
公開日2012-12-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Tetr(B) in Complex with Minocycline and Magnesium
To be Published
2TRT
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TETRACYCLINE REPRESSOR CLASS D
分子名称: MAGNESIUM ION, TETRACYCLINE, TETRACYCLINE REPRESSOR CLASS D
著者Hinrichs, W, Kisker, C, Saenger, W.
登録日1994-03-04
公開日1996-06-20
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
2XB5
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Tet repressor (class D) in complex with 7-Iodotetracycline
分子名称: 7-IODOTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ...
著者Kisker, C, Saenger, W, Hinrichs, W.
登録日2010-04-05
公開日2010-10-06
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
Science, 264, 1994
1QPI
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CRYSTAL STRUCTURE OF TETRACYCLINE REPRESSOR/OPERATOR COMPLEX
分子名称: DNA (5'-D(*CP*CP*TP*AP*TP*CP*AP*AP*TP*GP*AP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*TP*CP*AP*TP*TP*GP*AP*TP*AP*GP*G)-3'), IMIDAZOLE, ...
著者Orth, P, Schnappinger, D, Hillen, W, Saenger, W, Hinrichs, W.
登録日1999-05-25
公開日2000-02-28
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis of gene regulation by the tetracycline inducible Tet repressor-operator system.
Nat.Struct.Biol., 7, 2000
2NS8
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How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor
分子名称: 16 residue peptide Tip (Transcription inducing peptide), Tetracycline repressor protein
著者Luckner, S.R, Klotzsche, M, Berens, C, Hillen, W, Muller, Y.A.
登録日2006-11-03
公開日2007-07-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献How an agonist peptide mimics the antibiotic tetracycline to induce Tet-repressor
J.Mol.Biol., 368, 2007

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