1AUJ
 
 | | BOVINE TRYPSIN COMPLEXED TO META-CYANO-BENZYLIC INHIBITOR | | 分子名称: | 1-{[1-(2-AMINO-3-PHENYL-PROPIONYL)-PYRROLIDINE-2-CARBONYL]-AMINO}-2-(3-CYANO-PHENYL)-ETHANEBORONIC ACID, CALCIUM ION, TRYPSIN | | 著者 | Alexander, R, Smallwood, A, Kettner, C. | | 登録日 | 1997-08-28 | | 公開日 | 1998-10-14 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | New inhibitors of thrombin and other trypsin-like proteases: hydrogen bonding of an aromatic cyano group with a backbone amide of the P1 binding site replaces binding of a basic side chain.
Biochemistry, 36, 1997
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2TGD
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3OTJ
 | | A Crystal Structure of Trypsin Complexed with BPTI (Bovine Pancreatic Trypsin Inhibitor) by X-ray/Neutron Joint Refinement | | 分子名称: | CALCIUM ION, Cationic trypsin, Pancreatic trypsin inhibitor, ... | | 著者 | Kawamura, K, Yamada, T, Kurihara, K, Tamada, T, Kuroki, R, Tanaka, I, Takahashi, H, Niimura, N. | | 登録日 | 2010-09-12 | | 公開日 | 2011-01-26 | | 最終更新日 | 2017-11-08 | | 実験手法 | NEUTRON DIFFRACTION (2.15 Å), X-RAY DIFFRACTION | | 主引用文献 | X-ray and neutron protein crystallographic analysis of the trypsin-BPTI complex.
Acta Crystallogr.,Sect.D, 67, 2011
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1K1J
 | | BOVINE TRYPSIN-INHIBITOR COMPLEX | | 分子名称: | CALCIUM ION, N-ALPHA-(2-NAPHTHYLSULFONYL)-N(3-AMIDINO-L-PHENYLALANINYL)ISOPIPECOLINIC ACID METHYL ESTER, SULFATE ION, ... | | 著者 | Stubbs, M.T. | | 登録日 | 2001-09-25 | | 公開日 | 2001-11-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
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1K1M
 | | BOVINE TRYPSIN-INHIBITOR COMPLEX | | 分子名称: | CALCIUM ION, N-ALPHA-(2-NAPHTHYLSULFONYL)-N(3-AMIDINO-L-PHENYLALANINYL)-4-ACETYL-PIPERAZINE, SULFATE ION, ... | | 著者 | Stubbs, M.T. | | 登録日 | 2001-09-25 | | 公開日 | 2001-11-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
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1G9I
 | | CRYSTAL STRUCTURE OF BETA-TRYSIN COMPLEX IN CYCLOHEXANE | | 分子名称: | BOWMAN-BIRK TYPE TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | | 著者 | Zhu, G, Huang, Q, Zhu, Y, Li, Y, Chi, C, Tang, Y. | | 登録日 | 2000-11-24 | | 公開日 | 2000-12-06 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-Ray study on an artificial mung bean inhibitor complex with bovine beta-trypsin in neat cyclohexane.
Biochim.Biophys.Acta, 1546, 2001
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6DZF
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6FID
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4TPI
 | | THE REFINED 2.2-ANGSTROMS (0.22-NM) X-RAY CRYSTAL STRUCTURE OF THE TERNARY COMPLEX FORMED BY BOVINE TRYPSINOGEN, VALINE-VALINE AND THE ARG15 ANALOGUE OF BOVINE PANCREATIC TRYPSIN INHIBITOR | | 分子名称: | BOVINE PANCREATIC TRYPSIN INHIBITOR, CALCIUM ION, SULFATE ION, ... | | 著者 | Bode, W, Walter, J. | | 登録日 | 1985-06-11 | | 公開日 | 1985-11-08 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The refined 2.2-A (0.22-nm) X-ray crystal structure of the ternary complex formed by bovine trypsinogen, valine-valine and the Arg15 analogue of bovine pancreatic trypsin inhibitor
Eur.J.Biochem., 144, 1984
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8UO7
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1BTP
 | | UNIQUE BINDING OF A NOVEL SYNTHETIC INHIBITOR, N-[3-[4-[4-(AMIDINOPHENOXY)-CARBONYL]PHENYL]-2-METHYL-2-PROPENOYL]-N-ALLYLGLYCINE METHANESULFONATE TO BOVINE TRYPSIN, REVEALED BY THE CRYSTAL STRUCTURE OF THE COMPLEX | | 分子名称: | BETA-TRYPSIN, CALCIUM ION | | 著者 | Odagaki, Y, Nakai, H, Senokuchi, K, Kawamura, M, Hamanaka, N, Nakamura, M, Tomoo, K, Ishida, T. | | 登録日 | 1995-08-11 | | 公開日 | 1996-01-29 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Unique binding of a novel synthetic inhibitor, N-[3-[4-[4-(amidinophenoxy)carbonyl]phenyl]-2-methyl-2-propenoyl]- N-allylglycine methanesulfonate, to bovine trypsin, revealed by the crystal structure of the complex.
Biochemistry, 34, 1995
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3M35
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1AQ7
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1LQE
 | | CRYSTAL STRUCTURE OF TRYPSIN IN COMPLEX WITH 79. | | 分子名称: | CALCIUM ION, SULFATE ION, TRYPSIN, ... | | 著者 | Schreuder, H.A, Liesum, A. | | 登録日 | 2002-05-10 | | 公開日 | 2003-05-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides
as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
J.Med.Chem., 45, 2002
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1XUH
 | | TRYPSIN-KETO-BABIM-CO+2, PH 8.2 | | 分子名称: | BIS(5-AMIDINO-2-BENZIMIDAZOLYL)METHANONE, CALCIUM ION, COBALT (II) ION, ... | | 著者 | Katz, B.A, Clark, J.M, Finer-Moore, J.S, Jenkins, T.E, Johnson, C.R, Rose, M.J, Luong, C, Moore, W.R, Stroud, R.M. | | 登録日 | 1997-10-10 | | 公開日 | 1998-11-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Design of potent selective zinc-mediated serine protease inhibitors.
Nature, 391, 1998
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1K1I
 | | BOVINE TRYPSIN-INHIBITOR COMPLEX | | 分子名称: | CALCIUM ION, N-ALPHA-(2-NAPHTHYLSULFONYL)-N-(3-AMIDINO-L-PHENYLALANINYL)-D-PIPECOLINIC ACID, TRYPSIN | | 著者 | Stubbs, M.T. | | 登録日 | 2001-09-25 | | 公開日 | 2001-11-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition.
J.Mol.Biol., 313, 2001
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7VO7
 | | Crystal structure of trypsin in complex with Lima bean trypsin inhibitor at 2.25A resolution. | | 分子名称: | Bowman-Birk type proteinase inhibitor, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Ahmad, M.S, Akbar, Z, Choudhary, M.I. | | 登録日 | 2021-10-12 | | 公開日 | 2022-08-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Insight into the structural basis of the dual inhibitory mode of Lima bean (Phaseolus lunatus) serine protease inhibitor.
Proteins, 91, 2023
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2CMY
 | | Crystal complex between bovine trypsin and Veronica hederifolia trypsin inhibitor | | 分子名称: | CALCIUM ION, CATIONIC TRYPSIN, GLYCEROL, ... | | 著者 | Conners, R, Yardley, J.L, Konarev, A, Shewry, P, Brady, R.L. | | 登録日 | 2006-05-16 | | 公開日 | 2007-05-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | An Unusual Helix-Turn-Helix Protease Inhibitory Motif in a Novel Trypsin Inhibitor from Seeds of Veronica (Veronica Hederifolia L.).
J.Biol.Chem., 282, 2007
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3VEQ
 | | A binary complex betwwen bovine pancreatic trypsin and a engineered mutant trypsin inhibitor | | 分子名称: | CALCIUM ION, Cationic trypsin, Chymotrypsin inhibitor 3 | | 著者 | Sen, U, Majumder, S, Khamrui, S, Dasgupta, J. | | 登録日 | 2012-01-09 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Role of remote scaffolding residues in the inhibitory loop pre-organization, flexibility, rigidification and enzyme inhibition of serine protease inhibitors
Biochim.Biophys.Acta, 1824, 2012
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3RDZ
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8KDU
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1V2Q
 | | Trypsin inhibitor in complex with bovine trypsin variant X(SSWI)bT.B4 | | 分子名称: | CALCIUM ION, METHYL N-[(4-METHYLPHENYL)SULFONYL]GLYCYL-3-[AMINO(IMINO)METHYL]-D-PHENYLALANINATE, SULFATE ION, ... | | 著者 | Rauh, D, Klebe, G, Stubbs, M.T. | | 登録日 | 2003-10-17 | | 公開日 | 2004-06-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Understanding protein-ligand interactions: the price of protein flexibility
J.Mol.Biol., 335, 2004
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1TAB
 | | STRUCTURE OF THE TRYPSIN-BINDING DOMAIN OF BOWMAN-BIRK TYPE PROTEASE INHIBITOR AND ITS INTERACTION WITH TRYPSIN | | 分子名称: | BOWMAN-BIRK TYPE PROTEINASE INHIBITOR, TRYPSIN | | 著者 | Tsunogae, Y, Tanaka, I, Yamane, T, Kikkawa, J.-I, Ashida, T, Ishikawa, C, Watanabe, K, Nakamura, S, Takahashi, K. | | 登録日 | 1990-10-15 | | 公開日 | 1992-01-15 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the trypsin-binding domain of Bowman-Birk type protease inhibitor and its interaction with trypsin.
J.Biochem.(Tokyo), 100, 1986
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1D6R
 | | CRYSTAL STRUCTURE OF CANCER CHEMOPREVENTIVE BOWMAN-BIRK INHIBITOR IN TERNARY COMPLEX WITH BOVINE TRYPSIN AT 2.3 A RESOLUTION. STRUCTURAL BASIS OF JANUS-FACED SERINE PROTEASE INHIBITOR SPECIFICITY | | 分子名称: | BOWMAN-BIRK PROTEINASE INHIBITOR PRECURSOR, TRYPSINOGEN | | 著者 | Koepke, J, Ermler, U, Wenzl, G, Flecker, P. | | 登録日 | 1999-10-15 | | 公開日 | 2000-05-05 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of cancer chemopreventive Bowman-Birk inhibitor in ternary complex with bovine trypsin at 2.3 A resolution. Structural basis of Janus-faced serine protease inhibitor specificity.
J.Mol.Biol., 298, 2000
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1OPH
 | | NON-COVALENT COMPLEX BETWEEN ALPHA-1-PI-PITTSBURGH AND S195A TRYPSIN | | 分子名称: | Alpha-1-antitrypsin precursor, Trypsinogen, cationic precursor | | 著者 | Dementiev, A, Simonovic, M, Volz, K, Gettins, P.G. | | 登録日 | 2003-03-05 | | 公開日 | 2003-08-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
J.Biol.Chem., 278, 2003
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