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PDB: 48 件
5UGG
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Protease Inhibitor
分子名称: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen
著者Law, R.H.P, Wu, G, Whisstock, J.C.
登録日2017-01-08
公開日2017-05-31
最終更新日2020-01-08
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
6D3Y
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Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
分子名称: GLYCEROL, Plasminogen, SULFATE ION, ...
著者Law, R.H.P, Wu, G.
登録日2018-04-17
公開日2019-01-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
5UGD
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Protease Inhibitor
分子名称: Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide, Plasminogen
著者Law, R.H.P, Wu, G, Whisstock, J.C.
登録日2017-01-08
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
Blood Adv, 1, 2017
6D40
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Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
分子名称: Plasminogen, SULFATE ION, Trypsin inhibitor 1
著者Law, R.H.P, Wu, G.
登録日2018-04-17
公開日2019-01-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
8F7U
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Macrocyclic Plasmin Inhibitor
分子名称: (5S,8R,18S,21R)-N-{[4-(aminomethyl)phenyl]methyl}-21-[(benzenesulfonyl)amino]-3,11,20-trioxo-2,5,8,12,19-pentaazatetracyclo[21.2.2.2~5,8~.2~13,16~]hentriaconta-1(25),13,15,23,26,28-hexaene-18-carboxamide, Activation peptide, GLYCEROL, ...
著者Guojie, W.
登録日2022-11-20
公開日2023-02-08
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Synthesis and structural characterization of new macrocyclicplasmin inhibitors
Chemmedchem, 2023
7UAH
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Macrocyclic plasmin inhibitor
分子名称: (2~{R})-butane-1,2-diol, (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(3-chlorobenzene-1-sulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, Plasminogen, ...
著者Guojie, W.
登録日2022-03-12
公開日2023-03-15
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
Chemmedchem, 18, 2023
8F7V
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Macrocyclic plasmin inhibitor
分子名称: (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(benzenesulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, GLYCEROL, Plasminogen, ...
著者Guojie, W.
登録日2022-11-20
公開日2023-02-08
最終更新日2023-06-21
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Synthesis and structural characterization of new macrocyclicplasmin inhibitors
Chemmedchem, 2023
5HPG
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STRUCTURE AND LIGAND DETERMINANTS OF THE RECOMBINANT KRINGLE 5 DOMAIN OF HUMAN PLASMINOGEN
分子名称: PLASMINOGEN
著者Tulinsky, A, Mochalkin, I, Castellino, F.J.
登録日1997-09-19
公開日1998-03-25
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.
Biochemistry, 37, 1998
1KRN
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STRUCTURE OF KRINGLE 4 AT 4C TEMPERATURE AND 1.67 ANGSTROMS RESOLUTION
分子名称: PLASMINOGEN, SULFATE ION
著者Stec, B, Teeter, M.M, Whitlow, M, Yamano, A.
登録日1995-06-21
公開日1997-01-11
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structure of human plasminogen kringle 4 at 1.68 a and 277 K. A possible structural role of disordered residues.
Acta Crystallogr.,Sect.D, 53, 1997
6OG4
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plasminogen binding group A streptococcal M protein
分子名称: Plasminogen, Plasminogen-binding group A streptococcal M-like protein PAM, SULFATE ION
著者Law, R.H.P, Quek, A.J, Whisstock, J.C, Caradoc-Davies, T.T.
登録日2019-04-01
公開日2019-07-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding.
J.Mol.Biol., 431, 2019
1KI0
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The X-ray Structure of Human Angiostatin
分子名称: ANGIOSTATIN, BICINE
著者Abad, M.C, Arni, R.K, Grella, D.K, Castellino, F.J, Tulinsky, A, Geiger, J.H.
登録日2001-12-02
公開日2002-05-29
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin.
J.Mol.Biol., 318, 2002
4CIK
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plasminogen kringle 1 in complex with inhibitor
分子名称: 5-[(2R,4S)-2-(phenylmethyl)piperidin-4-yl]-1,2-oxazol-3-one, PLASMINOGEN
著者Xue, Y, Johansson, C, Cheng, L, Pettersen, D, Gustafsson, D.
登録日2013-12-10
公開日2014-06-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Discovery of the Fibrinolysis Inhibitor Azd6564, Acting Via Interference of a Protein-Protein Interaction.
Acs Med.Chem.Lett., 5, 2014
6D3X
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Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
分子名称: Plasminogen, Trypsin inhibitor 1
著者Law, R.H.P, Wu, G.
登録日2018-04-17
公開日2019-01-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
7THS
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BU of 7ths by Molmil
Macrocyclic plasmin inhibitor
分子名称: (2S)-butane-1,2-diol, (6S,9R,20R,23S)-N-{[4-(aminomethyl)phenyl]methyl}-20-[(benzenesulfonyl)amino]-3,13,21-trioxo-2,6,9,14,22-pentaazatetracyclo[23.2.2.2~6,9~.2~15,18~]tritriaconta-1(27),15,17,25,28,30-hexaene-23-carboxamide, Plasminogen, ...
著者Guojie, W.
登録日2022-01-12
公開日2023-01-18
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
Chemmedchem, 18, 2023
1PK4
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CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN PLASMINOGEN KRINGLE 4 REFINED AT 1.9-ANGSTROMS RESOLUTION
分子名称: PLASMINOGEN KRINGLE 4, SULFATE ION
著者Tulinsky, A, Mulichak, A.M.
登録日1991-07-18
公開日1993-10-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.
Biochemistry, 30, 1991
7E50
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Crystal structure of human microplasmin in complex with kazal-type inhibitor AaTI
分子名称: AAEL006007-PA, GLYCEROL, Plasminogen, ...
著者Varsha, A.W, Jobichen, C, Mok, Y.K.
登録日2021-02-16
公開日2022-02-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of Aedes aegypti trypsin inhibitor in complex with mu-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor.
Protein Sci., 31, 2022
1DDJ
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BU of 1ddj by Molmil
CRYSTAL STRUCTURE OF HUMAN PLASMINOGEN CATALYTIC DOMAIN
分子名称: PLASMINOGEN
著者Wang, X, Terzyan, S, Tang, J, Loy, J, Lin, X, Zhang, X.
登録日1999-11-10
公開日2000-02-18
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Human plasminogen catalytic domain undergoes an unusual conformational change upon activation.
J.Mol.Biol., 295, 2000
6D3Z
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Protease SFTI complex
分子名称: Plasminogen, Trypsin inhibitor 1
著者Law, R.H.P, Wu, G.
登録日2018-04-17
公開日2019-01-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
1QRZ
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CATALYTIC DOMAIN OF PLASMINOGEN
分子名称: PLASMINOGEN
著者Peisach, E, Wang, J, de los Santos, T, Reich, E, Ringe, D.
登録日1999-06-16
公開日1999-10-14
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the proenzyme domain of plasminogen.
Biochemistry, 38, 1999
4DCB
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Y. pestis Plasminogen Activator Pla in Complex with Human Plasminogen Activation Loop Peptide ALP11
分子名称: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, ...
著者Eren, E, van den Berg, B.
登録日2012-01-17
公開日2012-06-06
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.033 Å)
主引用文献Structural basis for activation of an integral membrane protease by lipopolysaccharide.
J.Biol.Chem., 287, 2012
1CEA
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THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH EACA (EPSILON-AMINOCAPROIC ACID)
分子名称: 6-AMINOHEXANOIC ACID, PLASMINOGEN
著者Tulinsky, A, Mathews, I.I.
登録日1995-12-03
公開日1996-04-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
1CEB
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THE STRUCTURE OF THE NON-COVALENT COMPLEX OF RECOMBINANT KRINGLE 1 DOMAIN OF HUMAN PLASMINOGEN WITH AMCHA (TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID)
分子名称: PLASMINOGEN, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID
著者Tulinsky, A, Mathews, I.I.
登録日1995-12-03
公開日1996-04-03
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Crystal structures of the recombinant kringle 1 domain of human plasminogen in complexes with the ligands epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexane-1-carboxylic Acid.
Biochemistry, 35, 1996
2PK4
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THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE
分子名称: 6-AMINOHEXANOIC ACID, HUMAN PLASMINOGEN KRINGLE 4
著者Tulinsky, A, Wu, T.-P.
登録日1991-07-18
公開日1993-10-31
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.
Biochemistry, 30, 1991
1PMK
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KRINGLE-KRINGLE INTERACTIONS IN MULTIMER KRINGLE STRUCTURES
分子名称: PLASMINOGEN KRINGLE 4
著者Padmanabhan, K, Tulinsky, A.
登録日1994-04-25
公開日1994-06-22
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Kringle-kringle interactions in multimer kringle structures.
Protein Sci., 3, 1994
1RJX
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Human PLASMINOGEN CATALYTIC DOMAIN, K698M MUTANT
分子名称: Plasminogen, SULFATE ION
著者Terzyan, S, Wakeham, N, Zhai, P, Rodgers, K, Zhang, X.C.
登録日2003-11-20
公開日2003-12-02
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Characterization of Lys-698 to met substitution in human plasminogen catalytic domain
Proteins, 56, 2004

 

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