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PDB: 68 件
4IGK
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BU of 4igk by Molmil
Structure of human BRCA1 BRCT in complex with ATRIP peptide
分子名称: ATRIP peptide, Breast cancer type 1 susceptibility protein, GLYCEROL
著者Liu, X, Ladias, J.A.A.
登録日2012-12-17
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
5EGG
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BU of 5egg by Molmil
Crystal structure of human ubiquitin-conjugating enzyme UBCH5C
分子名称: Ubiquitin-conjugating enzyme E2 D3
著者Zhu, L, Li, H, Wu, F, Zhu, J.
登録日2015-10-27
公開日2016-11-02
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
Acta Pharm Sin B, 7, 2017
1X23
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BU of 1x23 by Molmil
Crystal structure of ubch5c
分子名称: Ubiquitin-conjugating enzyme E2 D3
著者Nakanishi, M, Teshima, N, Mizushima, T, Murata, S, Tanaka, K, Yamane, T.
登録日2005-04-19
公開日2005-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of ubch5c
To be Published
1T15
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BU of 1t15 by Molmil
Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase
分子名称: BRCA1 interacting protein C-terminal helicase 1, Breast cancer type 1 susceptibility protein
著者Clapperton, J.A, Manke, I.A, Lowery, D.M, Ho, T, Haire, L.F, Yaffe, M.B, Smerdon, S.J.
登録日2004-04-15
公開日2004-05-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Nat.Struct.Mol.Biol., 11, 2004
4S3O
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BU of 4s3o by Molmil
PCGF5-RING1B-UbcH5c complex
分子名称: E3 ubiquitin-protein ligase RING2, Polycomb group RING finger protein 5, Ubiquitin-conjugating enzyme E2 D3, ...
著者Taherbhoy, A.M, Cochran, A.G.
登録日2015-03-23
公開日2015-07-15
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.
Nat Commun, 6, 2015
8UQA
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BU of 8uqa by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ...
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.049 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
5IFR
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BU of 5ifr by Molmil
Structure of the stable UBE2D3-UbDha conjugate
分子名称: GLYCEROL, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D3
著者Pruneda, J.N, Mulder, M.P.C, Witting, K, Ovaa, H, Komander, D.
登録日2016-02-26
公開日2016-05-11
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.
Nat.Chem.Biol., 12, 2016
4IFI
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BU of 4ifi by Molmil
Structure of human BRCA1 BRCT in complex with BAAT peptide
分子名称: ACETATE ION, BAAT peptide, Breast cancer type 1 susceptibility protein
著者Liu, X, Ladias, J.A.A.
登録日2012-12-14
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1.
Biochemistry, 52, 2013
8UQ9
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BU of 8uq9 by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ...
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
1T29
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BU of 1t29 by Molmil
Crystal structure of the BRCA1 BRCT repeats bound to a phosphorylated BACH1 peptide
分子名称: BACH1 phosphorylated peptide, Breast cancer type 1 susceptibility protein
著者Shiozaki, E.N, Gu, L, Yan, N, Shi, Y.
登録日2004-04-20
公開日2004-05-11
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.
Mol.Cell, 14, 2004
8UQ8
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BU of 8uq8 by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ...
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
3UGB
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BU of 3ugb by Molmil
UbcH5c~Ubiquitin Conjugate
分子名称: GLYCEROL, Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D3
著者Page, R.C, Pruneda, J.N, Klevit, R.E, Misra, S.
登録日2011-11-02
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates.
Biochemistry, 51, 2012
8AMS
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BU of 8ams by Molmil
Complex of human TRIM2 RING domain, UBCH5C, and Ubiquitin
分子名称: 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, Polyubiquitin-C, ...
著者Perez-Borrajero, C, Kotova, I, Murciano, B, Hennig, J.
登録日2022-08-04
公開日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and biophysical studies of TRIM2 and TRIM3
To Be Published
8UQB
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BU of 8uqb by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1)
分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.484 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
4Y2G
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BU of 4y2g by Molmil
Structure of BRCA1 BRCT domains in complex with Abraxas single phosphorylated peptide
分子名称: BRCA1-A complex subunit Abraxas, Breast cancer type 1 susceptibility protein
著者Wu, Q, Blundell, T.L.
登録日2015-02-09
公開日2016-01-27
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites.
Mol.Cell, 61, 2016
1JNX
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BU of 1jnx by Molmil
Crystal structure of the BRCT repeat region from the breast cancer associated protein, BRCA1
分子名称: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, NICKEL (II) ION
著者Williams, R.S, Green, R, Glover, J.N.M.
登録日2001-07-26
公開日2001-09-21
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1.
Nat.Struct.Biol., 8, 2001
3PXB
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BU of 3pxb by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: T1700A
分子名称: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
著者Coquelle, N, Green, R, Glover, J.N.M.
登録日2010-12-09
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
1Y98
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BU of 1y98 by Molmil
Structure of the BRCT repeats of BRCA1 bound to a CtIP phosphopeptide.
分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, CtIP PHOSPHORYLATED PEPTIDE, ...
著者Varma, A.K, Brown, R.S, Birrane, G, Ladias, J.A.A.
登録日2004-12-14
公開日2005-08-30
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
3PXA
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BU of 3pxa by Molmil
Impact of BRCA1 BRCT domain missense substitutions on phospho-peptide recognition: G1656D
分子名称: Breast cancer type 1 susceptibility protein, NICKEL (II) ION, SULFATE ION
著者Coquelle, N, Green, R, Glover, J.N.M.
登録日2010-12-09
公開日2011-04-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition.
Biochemistry, 50, 2011
6T7F
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BU of 6t7f by Molmil
RCR E3 ligase E2-Ubiquitin transthiolation intermediate
分子名称: 3,3-bis(sulfanyl)-~{N}-(1~{H}-1,2,3-triazol-4-ylmethyl)propanamide, E3 ubiquitin-protein ligase MYCBP2, Polyubiquitin-C, ...
著者Mabbitt, P.D, Virdee, S.
登録日2019-10-21
公開日2020-08-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity.
Nat.Chem.Biol., 16, 2020
8UQC
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BU of 8uqc by Molmil
Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2)
分子名称: E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-10-23
公開日2024-01-17
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Mechanisms of RNF168 nucleosome recognition and ubiquitylation.
Mol.Cell, 84, 2024
3RPG
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BU of 3rpg by Molmil
Bmi1/Ring1b-UbcH5c complex structure
分子名称: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, Ubiquitin-conjugating enzyme E2 D3, ...
著者Bentley, M.L, Dong, K.C, Cochran, A.G.
登録日2011-04-26
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6485 Å)
主引用文献Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.
Embo J., 30, 2011
4BVU
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BU of 4bvu by Molmil
Structure of Shigella effector OspG in complex with host UbcH5c- Ubiquitin conjugate
分子名称: PROTEIN KINASE OSPG, UBIQUITIN, UBIQUITIN-CONJUGATING ENZYME E2 D3
著者Pruneda, J.N, LeTrong, I, Stenkamp, R.E, Klevit, R.E, Brzovic, P.S.
登録日2013-06-28
公開日2014-01-29
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献E2~Ub Conjugates Regulate the Kinase Activity of Shigella Effector Ospg During Pathogenesis.
Embo J., 33, 2014
3K0H
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BU of 3k0h by Molmil
The crystal structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with an amidated C-terminus
分子名称: Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ...
著者Campbell, S.J, Edwards, R.A, Glover, J.N.
登録日2009-09-24
公開日2010-03-02
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010
3K0K
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BU of 3k0k by Molmil
Crystal Structure of BRCA1 BRCT in complex with a minimal recognition tetrapeptide with a free carboxy C-terminus.
分子名称: Breast cancer type 1 susceptibility protein, CHLORIDE ION, NICKEL (II) ION, ...
著者Campbell, S.J, Edwards, R.A, Glover, J.N.
登録日2009-09-24
公開日2010-03-02
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Comparison of the Structures and Peptide Binding Specificities of the BRCT Domains of MDC1 and BRCA1
Structure, 18, 2010

 

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