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PDB: 88 件
7QTI
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BU of 7qti by Molmil
SARS-CoV-2 S Omicron Spike B.1.1.529 - 3-P2G3 and 1-P5C3 Fabs (Global)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P2G3 Heavy Chain, ...
著者Ni, D, Lau, K, Turelli, P, Fenwick, C, Perez, L, Pojer, F, Stahlberg, H, Pantaleo, G, Trono, D.
登録日2022-01-14
公開日2022-08-03
最終更新日2022-09-07
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys.
Nat Microbiol, 7, 2022
4MMT
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BU of 4mmt by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5
分子名称: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2
著者Joyce, M.G, Mclellan, J.S, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
登録日2013-09-09
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
5EA5
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BU of 5ea5 by Molmil
Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, D(-)-TARTARIC ACID, ...
著者Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
登録日2015-10-15
公開日2015-12-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5U68
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BU of 5u68 by Molmil
Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus
分子名称: Chimera protein of Fusion glycoprotein F0 and Envelope glycoprotein, MPE8
著者Wen, X, Jardetzky, T.S.
登録日2016-12-07
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.083 Å)
主引用文献Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus.
Nat Microbiol, 2, 2017
4MMR
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BU of 4mmr by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 9.5
分子名称: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2
著者Stewart-Jones, G.B.E, McLellan, J.S, Joyce, M.G, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
登録日2013-09-09
公開日2013-11-20
最終更新日2021-06-02
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
7TN1
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BU of 7tn1 by Molmil
Multistate design to stabilize viral class I fusion proteins
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
著者Huang, J, Banerjee, A, Gonzalez, K, Mousa, J, Strauch, E.
登録日2022-01-20
公開日2023-07-12
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献A general computational design strategy for stabilizing viral class I fusion proteins.
Nat Commun, 15, 2024
6W16
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BU of 6w16 by Molmil
Crystal structure of a human metapneumovirus monomeric fusion protein complexed with 458 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 458 Fab heavy chain, 458 Fab light chain, ...
著者Huang, J, Mousa, J.J.
登録日2020-03-03
公開日2020-06-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Antibody recognition of the Pneumovirus fusion protein trimer interface.
Plos Pathog., 16, 2020
5TPN
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BU of 5tpn by Molmil
Crystal structure of RSV F in complex with human antibody hRSV90
分子名称: Fusion glycoprotein F0,Fibritin, hRSV0 light chain, hRSV90 heavy chain
著者Mousa, J.J, Crowe, J.E.
登録日2016-10-20
公開日2017-02-01
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.141 Å)
主引用文献Crystal structure of RSV F in complex with human antibody hRSV90
To Be Published
8KG5
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Prefusion RSV F Bound to Lonafarnib and D25 Fab
分子名称: 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ...
著者Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X.
登録日2023-08-17
公開日2024-06-19
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein.
Signal Transduct Target Ther, 9, 2024
3RRT
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BU of 3rrt by Molmil
Structure of the RSV F protein in the post-fusion conformation
分子名称: Fusion glycoprotein F0
著者McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D.
登録日2011-04-30
公開日2011-06-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
3RKI
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BU of 3rki by Molmil
Structural basis for immunization with post-fusion RSV F to elicit high neutralizing antibody titers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
著者Swanson, K.A, Settembre, E.C, Shaw, C.A, Dey, A.K, Rappuoli, R, Mandl, C.W, Dormitzer, P.D, Carfi, A.
登録日2011-04-18
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers.
Proc.Natl.Acad.Sci.USA, 108, 2011
7L7F
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BU of 7l7f by Molmil
Cryo-EM structure of human ACE2 receptor bound to protein encoded by vaccine candidate BNT162b1
分子名称: Angiotensin-converting enzyme 2, Spike glycoprotein, Envelope glycoprotein fusion
著者Lees, J.A, Han, S.
登録日2020-12-28
公開日2021-02-24
最終更新日2021-04-21
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献BNT162b vaccines protect rhesus macaques from SARS-CoV-2.
Nature, 592, 2021
7FJN
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BU of 7fjn by Molmil
Cryo-EM structure of South African (B.1.351) SARS-CoV-2 spike glycoprotein in complex with two T6 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein, T6 heavy chain, ...
著者Wang, X, Zhang, L, Zhang, S, Liang, Q.
登録日2021-08-04
公開日2022-04-27
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献RBD trimer mRNA vaccine elicits broad and protective immune responses against SARS-CoV-2 variants.
Iscience, 25, 2022
4MMQ
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BU of 4mmq by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant DS
分子名称: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, SULFATE ION
著者Mclellan, J.S, Joyce, M.G, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
登録日2013-09-09
公開日2013-11-20
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.253 Å)
主引用文献Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
6OE4
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BU of 6oe4 by Molmil
Prefusion RSV F monomer bound by neutralizing antibody CR9501
分子名称: 1,2-ETHANEDIOL, CR9501 Fab Heavy Chain, CR9501 Fab Light Chain, ...
著者McLellan, J.S, Gilman, M.S.A.
登録日2019-03-27
公開日2019-04-17
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Transient opening of trimeric prefusion RSV F proteins.
Nat Commun, 10, 2019
5TOJ
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BU of 5toj by Molmil
Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Fibritin chimera, ...
著者Gilman, M.S.A, Kabeche, S.C, McLellan, J.S.
登録日2016-10-17
公開日2017-02-22
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
6EAG
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BU of 6eag by Molmil
CRYSTAL STRUCTURE OF FUSION INHIBITOR JNJ-2408068 IN COMPLEX WITH HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, D(-)-TARTARIC ACID, ...
著者Battles, M.B, McLellan, J.S.
登録日2018-08-03
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.302 Å)
主引用文献Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
5W23
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BU of 5w23 by Molmil
Crystal Structure of RSV F in complex with 5C4 Fab
分子名称: 5C4 Fab heavy chain, 5C4 Fab light chain, Fusion glycoprotein F0, ...
著者Battles, M.B, McLellan, J.S.
登録日2017-06-05
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein.
Nat Commun, 8, 2017
7MPG
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BU of 7mpg by Molmil
Cryo-EM structure of Prefusion-stabilized RSV F (DS-Cav1) in complex with Fab AM14
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者Abeyrathne, P.D, Malito, E, Harshbarger, W.D.
登録日2021-05-04
公開日2021-09-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13
6OUS
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BU of 6ous by Molmil
Structure of fusion glycoprotein from human respiratory syncytial virus
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, ...
著者Su, H.P.
登録日2019-05-05
公開日2019-10-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.
Nat Commun, 10, 2019
7KC1
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Cryo-EM structure of SRR2899884.46167H+MEDI8852L fab in complex with Victoria HA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain, ...
著者Gorman, J, Kwong, P.D.
登録日2020-10-04
公開日2021-05-12
最終更新日2021-07-14
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses.
Front Immunol, 12, 2021
5UDC
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BU of 5udc by Molmil
Crystal Structure of RSV F A2 Bound to MEDI8897
分子名称: CHLORIDE ION, Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, ...
著者McLellan, J.S.
登録日2016-12-26
公開日2017-05-17
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.45 Å)
主引用文献A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
Sci Transl Med, 9, 2017
6DC5
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BU of 6dc5 by Molmil
RSV prefusion F in complex with AM22 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Jones, H.G, McLellan, J.S.
登録日2018-05-04
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Alternative conformations of a major antigenic site on RSV F.
Plos Pathog., 15, 2019
6DC3
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BU of 6dc3 by Molmil
RSV prefusion F bound to RSD5 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab RSD5-Germline Heavy Chain, Fab RSD5-Germline Light Chain, ...
著者Battles, M.B, McLellan, J.S, Jones, H.J.
登録日2018-05-04
公開日2019-07-10
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.501 Å)
主引用文献Alternative conformations of a major antigenic site on RSV F.
Plos Pathog., 15, 2019
7MMN
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BU of 7mmn by Molmil
Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者Harshbarger, W, Malito, E.
登録日2021-04-29
公開日2021-09-08
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.57 Å)
主引用文献Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein.
Mabs, 13, 2021

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件を2024-08-07に公開中

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