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PDB: 8 件
8B07
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BU of 8b07 by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin
分子名称: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, SINEFUNGIN
著者Silhan, J, Klima, M, Boura, E.
登録日2022-09-07
公開日2023-04-05
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8OIV
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BU of 8oiv by Molmil
Monkeypox virus VP39 in complex with SAH and cap0
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Skvara, P, Chalupska, D, Silhan, J, Klima, M, Boura, E.
登録日2023-03-23
公開日2023-08-23
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Structural basis for RNA-cap recognition and methylation by the mpox methyltransferase VP39.
Antiviral Res., 216, 2023
8CEV
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BU of 8cev by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO1119
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-iodanyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
著者Klima, M, Silhan, J, Boura, E.
登録日2023-02-02
公開日2023-04-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CGB
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BU of 8cgb by Molmil
Monkeypox virus VP39 in complex with SAH
分子名称: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
著者Silhan, J, Klima, M, Skvara, P, Boura, E.
登録日2023-02-03
公開日2023-04-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CEQ
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BU of 8ceq by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO427
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
著者Klima, M, Silhan, J, Boura, E.
登録日2023-02-02
公開日2023-04-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CES
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BU of 8ces by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO500
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-[2-(1~{H}-benzimidazol-2-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
著者Klima, M, Silhan, J, Boura, E.
登録日2023-02-02
公開日2023-04-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CET
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BU of 8cet by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO507
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-quinolin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
著者Klima, M, Silhan, J, Boura, E.
登録日2023-02-02
公開日2023-04-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023
8CER
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BU of 8cer by Molmil
Crystal structure of monkeypox virus methyltransferase VP39 in complex with inhibitor TO494
分子名称: (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-naphthalen-1-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
著者Klima, M, Silhan, J, Boura, E.
登録日2023-02-02
公開日2023-04-05
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.
Nat Commun, 14, 2023

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件を2024-07-10に公開中

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