6A71
 
 | | Crystal Structure of Human ATP7B and TM Complex | | Descriptor: | ATP7B protein, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Chen, W.B. | | Deposit date: | 2018-06-30 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein.
Nat Commun, 10, 2019
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7ZC3
 | | Crystal structure of human copper chaperone Atox1 bound to zinc ion by CxxC motif | | Descriptor: | Copper transport protein ATOX1, SULFATE ION, ZINC ION | | Authors: | Mangini, V, Belviso, B.D, Arnesano, F, Caliandro, R. | | Deposit date: | 2022-03-25 | | Release date: | 2022-04-06 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of the Human Copper Chaperone ATOX1 Bound to Zinc Ion.
Biomolecules, 12, 2022
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2QIF
 | | Crystal structure of a metallochaperone with a tetranuclear Cu(I) cluster | | Descriptor: | ACETATE ION, CALCIUM ION, COPPER (I) ION, ... | | Authors: | West, C, Singleton, C, Kihlken, M.A, Le Brun, N.E, Hemmings, A.M. | | Deposit date: | 2007-07-04 | | Release date: | 2008-07-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ.
Biochemistry, 48, 2009
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1FE0
 | | CRYSTAL STRUCTURE OF CADMIUM-HAH1 | | Descriptor: | CADMIUM ION, COPPER TRANSPORT PROTEIN ATOX1, SULFATE ION, ... | | Authors: | Wernimont, A.K, Huffman, D.L, Lamb, A.L, O'Halloran, T.V, Rosenzweig, A.C. | | Deposit date: | 2000-07-20 | | Release date: | 2001-01-20 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins.
Nat.Struct.Biol., 7, 2000
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2G9O
 | | Solution structure of the apo form of the third metal-binding domain of ATP7A protein (Menkes Disease protein) | | Descriptor: | Copper-transporting ATPase 1 | | Authors: | Banci, L, Bertini, I, Cantini, F, DellaMalva, N, Rosato, A, Herrmann, T, Wuthrich, K, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2006-03-07 | | Release date: | 2006-08-01 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein.
J.Biol.Chem., 281, 2006
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7DC1
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5F0W
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4QOT
 | | Crystal structure of human copper chaperone bound to the platinum ion | | Descriptor: | Copper transport protein ATOX1, PLATINUM (II) ION, SULFATE ION | | Authors: | Belviso, B.D, Galliani, A, Caliandro, R, Arnesano, F, Natile, G. | | Deposit date: | 2014-06-20 | | Release date: | 2015-06-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Oxaliplatin Binding to Human Copper Chaperone Atox1 and Protein Dimerization
Inorg.Chem., 55, 2016
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5T7L
 | | Pt(II)-mediated copper-dependent interactions between ATOX1 and MNK1 | | Descriptor: | COPPER (II) ION, Copper transport protein ATOX1, Copper-transporting ATPase 1, ... | | Authors: | Caliandro, R, Mirabelli, V, Caliandro, R, Rosato, A, Lasorsa, A, Galliani, A, Arnesano, F, Natile, G. | | Deposit date: | 2016-09-05 | | Release date: | 2016-10-12 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.
J.Am.Chem.Soc., 141, 2019
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1MWZ
 | | Solution structure of the N-terminal domain of ZntA in the Zn(II)-form | | Descriptor: | ZINC ION, ZntA | | Authors: | Banci, L, Bertini, I, Ciofi-Baffoni, S, Finney, L.A, Outten, C.E, O'Halloran, T.V. | | Deposit date: | 2002-10-01 | | Release date: | 2002-11-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the apo and Zn(II) forms of ZntA (46-118)
J.Mol.Biol., 323, 2002
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1MWY
 | | Solution structure of the N-terminal domain of ZntA in the apo-form | | Descriptor: | ZntA | | Authors: | Banci, L, Bertini, I, Ciofi-Baffoni, S, Finney, L.A, Outten, C.E, O'Halloran, T.V. | | Deposit date: | 2002-10-01 | | Release date: | 2002-11-06 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A new zinc-protein coordination site in intracellular metal trafficking: solution structure of the apo and Zn(II) forms of ZntA (46-118)
J.Mol.Biol., 323, 2002
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4Y2K
 | | reduced form of apo-GolB | | Descriptor: | Putative metal-binding transport protein | | Authors: | Wei, W, Wang, F, Ma, L, Zhao, J. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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4Y2I
 | | Gold ion bound to GolB | | Descriptor: | GOLD ION, Putative metal-binding transport protein | | Authors: | Wei, W, Wang, F, Ma, L, Zhao, J. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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3CJK
 | | Crystal structure of the adduct HAH1-Cd(II)-MNK1. | | Descriptor: | CADMIUM ION, Copper transport protein ATOX1, Copper-transporting ATPase 1 | | Authors: | Banci, L, Bertini, I, Calderone, V, Felli, I, Della-Malva, N, Pavelkova, A, Rosato, A. | | Deposit date: | 2008-03-13 | | Release date: | 2008-12-30 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.
Biochem.J., 422, 2009
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5ZCZ
 | | Solution structure of the T. Thermophilus HB8 TTHA1718 protein in living eukaryotic cells by in-cell NMR spectroscopy | | Descriptor: | Heavy metal binding protein | | Authors: | Tanaka, T, Teppei, I, Kamoshida, H, Mishima, M, Shirakawa, M, Guentert, P, Ito, Y. | | Deposit date: | 2018-02-22 | | Release date: | 2019-08-21 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells.
Angew.Chem.Int.Ed.Engl., 58, 2019
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6A72
 | | Copper transporter protein | | Descriptor: | ATP7B protein, CALCIUM ION, dioxo(di-mu-sulfide)dimolybdenum | | Authors: | Chen, W.B. | | Deposit date: | 2018-07-01 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the protein.
Nat Commun, 10, 2019
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8R7D
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8R7A
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3DXS
 | | Crystal structure of a copper binding domain from HMA7, a P-type ATPase | | Descriptor: | Copper-transporting ATPase RAN1, LITHIUM ION, ZINC ION | | Authors: | Zimmermann, M, Xiao, Z, Clarke, O.B, Gulbis, J.M, Wedd, A.G. | | Deposit date: | 2008-07-25 | | Release date: | 2009-08-11 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains.
Biochemistry, 48, 2009
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4Y2M
 | | apo-GolB protein | | Descriptor: | GOLD ION, Putative metal-binding transport protein | | Authors: | Wei, W, Zhao, J, Wang, F. | | Deposit date: | 2015-02-10 | | Release date: | 2016-02-10 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Insights and the Surprisingly Low Mechanical Stability of the Au-S Bond in the Gold-Specific Protein GolB
J.Am.Chem.Soc., 137, 2015
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4YEA
 | | Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement | | Descriptor: | COPPER (II) ION, Copper transport protein ATOX1, SULFATE ION | | Authors: | Shabalin, I.G, Dauter, Z, Jaskolski, M, Minor, W, Wlodawer, A. | | Deposit date: | 2015-02-23 | | Release date: | 2015-03-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Acta Crystallogr.,Sect.D, 71, 2015
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5VDF
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4YDX
 | | Crystal structure of cisplatin bound to a human copper chaperone (monomer) - new refinement | | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, Copper transport protein ATOX1, PLATINUM (II) ION, ... | | Authors: | Shabalin, I.G, Boal, A.K, Dauter, Z, Jaskolski, M, Minor, W, Rosenzweig, A.C, Wlodawer, A. | | Deposit date: | 2015-02-23 | | Release date: | 2015-03-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.602 Å) | | Cite: | Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Acta Crystallogr.,Sect.D, 71, 2015
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5VDE
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6FF1
 | | CsoZ metallochaperone | | Descriptor: | CALCIUM ION, CsoZ | | Authors: | Pelicioli-Riboldi, G, Basle, A, Waldron, K. | | Deposit date: | 2018-01-03 | | Release date: | 2019-01-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | The copper homeostasis system of Staphylococcus aureus:
Two putative metallochaperones with contrasting copper binding properties.
To Be Published
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