9F31
 
 | | Crystal structure of MELK with a covalent compound GCL 99 | | Descriptor: | Maternal embryonic leucine zipper kinase, N-[4-(1H-indazol-5-yl)phenyl]propanamide | | Authors: | Wang, G.Q, Seidler, N, Gehringer, M, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2024-04-24 | | Release date: | 2025-03-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Probing the Protein Kinases' Cysteinome by Covalent Fragments.
Angew.Chem.Int.Ed.Engl., 64, 2025
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4OOK
 | | Third Metal bound M.tuberculosis methionine aminopeptidase | | Descriptor: | COBALT (II) ION, Methionine aminopeptidase 2, SODIUM ION | | Authors: | Reddi, R, Addlagatta, A. | | Deposit date: | 2014-02-03 | | Release date: | 2015-02-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
Febs J., 281, 2014
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2NC2
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7KYZ
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7ZI0
 | | Structure of human Smoothened in complex with cholesterol and SAG | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ... | | Authors: | Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C. | | Deposit date: | 2022-04-07 | | Release date: | 2022-06-15 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv, 8, 2022
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6GBN
 | | Crystal structure of S-adenosyl-L-homocysteine hydrolase from Cytophaga hutchinsonii in complex with adenosine | | Descriptor: | ADENOSINE, Adenosylhomocysteinase, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Czyrko, J, Jaskolski, M, Brzezinski, K. | | Deposit date: | 2018-04-15 | | Release date: | 2018-08-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Crystal structure of S-adenosyl-L-homocysteine hydrolase from Cytophaga hutchinsonii, a case of combination of crystallographic and non-crystallographic symmetry.
Croatica Chemica Acta, 91, 2018
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2JP0
 | | Solution structure of the N-terminal extraceullular domain of the lymphocyte receptor CD5 calculated using inferential structure determination (ISD) | | Descriptor: | T-cell surface glycoprotein CD5 | | Authors: | Garza-Garcia, A, Harris, R, Esposito, D, Driscoll, P.C, Rieping, W. | | Deposit date: | 2007-04-16 | | Release date: | 2008-02-26 | | Last modified: | 2024-11-27 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional solution structure and conformational plasticity of the N-terminal scavenger receptor cysteine-rich domain of human CD5
J.Mol.Biol., 378, 2008
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2JOP
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3PNR
 | | Structure of PbICP-C in complex with falcipain-2 | | Descriptor: | CADMIUM ION, Falcipain 2, GLYCEROL, ... | | Authors: | Hansen, G, Hilgenfeld, R. | | Deposit date: | 2010-11-19 | | Release date: | 2011-07-27 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.
Structure, 19, 2011
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8P1Z
 | | Arabidopsis thaliana cytosolic seryl-tRNA synthetase in addition of dithiothreitol (DTT) | | Descriptor: | Serine--tRNA ligase, cytoplasmic | | Authors: | Kekez, I, Soic, R, Rokov-Plavec, J, Matkovic-Calogovic, D. | | Deposit date: | 2023-05-13 | | Release date: | 2024-05-22 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation.
Febs Lett., 597, 2023
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8P1Y
 | | Arabidopsis thaliana mutated variant C244S of seryl-tRNA synthetase | | Descriptor: | Serine--tRNA ligase, cytoplasmic | | Authors: | Kekez, I, Soic, R, Rokov-Plavec, J, Matkovic-Calogovic, D. | | Deposit date: | 2023-05-13 | | Release date: | 2024-05-22 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Evolutionarily conserved cysteines in plant cytosolic seryl-tRNA synthetase are important for its resistance to oxidation.
Febs Lett., 597, 2023
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4MAO
 | | RSK2 T493M C-Terminal Kinase Domain in Complex with RMM58 | | Descriptor: | (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | Authors: | Miller, R.M, Taunton, J. | | Deposit date: | 2013-08-16 | | Release date: | 2014-10-22 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
J.Am.Chem.Soc., 136, 2014
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7XES
 | | NifS with L-penicillamine | | Descriptor: | (2~{R})-3-methyl-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-sulfanyl-butanoic acid, CHLORIDE ION, Cysteine desulfurase IscS, ... | | Authors: | Nakamura, R, Fujishiro, T. | | Deposit date: | 2022-03-31 | | Release date: | 2023-04-05 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | X-ray crystallographic snapshots of the thioazolidine formation upon the PLP during inhibition of SufS by D-cysteine
to be published
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6AY8
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1PFP
 | | CATHELIN-LIKE MOTIF OF PROTEGRIN-3 | | Descriptor: | Protegrin 3 | | Authors: | Strub, M.-P, Hoh, F, Sanchez, J.-F, Strub, J.M, Bock, A, Aumelas, A, Dumas, C. | | Deposit date: | 2003-05-27 | | Release date: | 2003-11-11 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing
Structure, 11, 2003
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5FNV
 | | a new complex structure of tubulin with an alpha-beta unsaturated lactone | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wang, Y, Naismith, J, Zhu, X. | | Deposit date: | 2015-11-16 | | Release date: | 2016-05-18 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.61 Å) | | Cite: | Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule.
Nat.Commun., 7, 2016
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6AY7
 | | Cartilage homing cysteine-dense-peptides | | Descriptor: | CHLORIDE ION, Potassium channel toxin alpha-KTx 3.5, SULFATE ION, ... | | Authors: | Gewe, M.M, Strong, R.K. | | Deposit date: | 2017-09-07 | | Release date: | 2018-08-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Cartilage homing cysteine-dense-peptides
To Be Published
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5G3P
 | | Bacillus cereus formamidase (BceAmiF) acetylated at the active site. | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Gavira, J.A, Conejero-Muriel, M, Martinez-Rodriguez, S. | | Deposit date: | 2016-04-29 | | Release date: | 2017-04-12 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | A novel cysteine carbamoyl-switch is responsible for the inhibition of formamidase, a nitrilase superfamily member.
Arch.Biochem.Biophys., 662, 2019
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5G3O
 | | Bacillus cereus formamidase (BceAmiF) inhibited with urea. | | Descriptor: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, FORMAMIDASE, ... | | Authors: | Gavira, J.A, Martinez-Rodriguez, S, Conejero-Muriel, M. | | Deposit date: | 2016-04-29 | | Release date: | 2017-04-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | A novel cysteine carbamoyl-switch is responsible for the inhibition of formamidase, a nitrilase superfamily member.
Arch.Biochem.Biophys., 662, 2019
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1PAE
 | | nucleoside diphosphate kinase | | Descriptor: | Nucleoside diphosphate kinase, cytosolic, SELENIUM ATOM | | Authors: | Strub, M.-P, Hoh, F, Sanchez, J.-F, Strub, J.M, Bock, A, Aumelas, A, Dumas, C. | | Deposit date: | 2003-05-14 | | Release date: | 2003-11-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Selenomethionine and Selenocysteine Double Labeling Strategy for Crystallographic Phasing
Structure, 11, 2003
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5YJH
 | | Structural insights into periostin functions | | Descriptor: | CALCIUM ION, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Liu, H, Liu, J, Xu, F. | | Deposit date: | 2017-10-10 | | Release date: | 2018-05-23 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.957 Å) | | Cite: | Structural characterizations of human periostin dimerization and cysteinylation.
FEBS Lett., 592, 2018
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3ZZJ
 | | Structure of an engineered aspartate aminotransferase | | Descriptor: | ASPARTATE AMINOTRANSFERASE, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Fernandez, F.J, deVries, D, Pena-Soler, E, Coll, M, Christen, P, Gehring, H, Vega, M.C. | | Deposit date: | 2011-09-01 | | Release date: | 2011-12-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure and Mechanism of a Cysteine Sulfinate Desulfinase Engineered on the Aspartate Aminotransferase Scaffold.
Biocim.Biophys.Acta, 1824, 2011
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4XCH
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4BBG
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6XYH
 | | NMR solution structure of alpha-AnmTX-Ms11a-2 (Ms11a-2) | | Descriptor: | AMS3 | | Authors: | Mineev, K.S, Kornilov, F.D, Lushpa, V.A, Logashina, Y.A, Maleeva, E.E, Andreev, Y.A. | | Deposit date: | 2020-01-30 | | Release date: | 2021-02-10 | | Last modified: | 2025-02-19 | | Method: | SOLUTION NMR | | Cite: | Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors.
Toxins, 15, 2022
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