6F6R
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![BU of 6f6r by Molmil](/molmil-images/mine/6f6r) | Crystal structure of human Caspase-1 with N-{3-[1-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-ylcarbamoyl)-ethyl]-1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl}-4-(quinoxalin-2-ylamino)-benzamide | Descriptor: | (3~{S})-3-[[(2~{R})-2-[3-methyl-2,6-bis(oxidanylidene)-5-[[4-(quinoxalin-2-ylamino)phenyl]carbonylamino]pyrimidin-1-yl]propanoyl]amino]-4-oxidanyl-butanoic acid, Caspase-1, SULFATE ION | Authors: | Fournier, J.F, Clary, L, Chambon, S, Dumais, L, Harris, C.S, Millois-Barbuis, C, Pierre, R, Talano, S, Thoreau, E, Aubert, J, Aurelly, M, Bouix-Peter, C, Brethon, A, Chantalat, L, Christin, O, Comino, C, El-Bazbouz, G, Ghilini, A.L, Isabet, T, Lardy, C, Luzy, A.P, Mathieu, C, Mebrouk, K, Orfila, D, Pascau, J, Reverse, K, Roche, D, Rodeschini, V, Hennequin, L.F. | Deposit date: | 2017-12-06 | Release date: | 2018-05-02 | Last modified: | 2018-05-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne. J. Med. Chem., 61, 2018
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6F1J
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![BU of 6f1j by Molmil](/molmil-images/mine/6f1j) | Structure of a Talaromyces pinophilus GH62 Arabinofuranosidase in complex with AraDNJ at 1.25A resolution | Descriptor: | 1,4-DIDEOXY-1,4-IMINO-L-ARABINITOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Moroz, O.V, Sobala, L, Blagova, E, Coyle, T, Morkeberg Krogh, K.B.R, Wei, P, Stubbs, K, Wilson, K.S, Davies, G.J. | Deposit date: | 2017-11-22 | Release date: | 2018-08-15 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 angstrom resolution. Acta Crystallogr F Struct Biol Commun, 74, 2018
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2C1Q
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![BU of 2c1q by Molmil](/molmil-images/mine/2c1q) | X-ray structure of biotin binding protein from chicken | Descriptor: | BIOTIN, BIOTIN BINDING PROTEIN A, GLYCEROL | Authors: | Hytonen, V.P, Niskanen, E.A, Maatta, J.A.E, Huuskonen, J, Helttunen, K.J, Halling, K.K, Slotte, J.P, Nordlund, H.R, Rissanen, K, Johnson, M.S, Salminen, T.A, Kulomaa, M.S, Laitinen, O.H, Airenne, T.T. | Deposit date: | 2005-09-19 | Release date: | 2007-02-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Characterization of a Novel Chicken Biotin-Binding Protein a (Bbp-A). Bmc Struct.Biol., 7, 2007
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1F30
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![BU of 1f30 by Molmil](/molmil-images/mine/1f30) | THE STRUCTURAL BASIS FOR DNA PROTECTION BY E. COLI DPS PROTEIN | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DNA PROTECTION DURING STARVATION PROTEIN, ZINC ION | Authors: | Luo, J, Liu, D, White, M.A, Fox, R.O. | Deposit date: | 2000-05-31 | Release date: | 2003-06-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Structural Basis for DNA Protection by E. coli Dps Protein To be Published
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2IHB
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![BU of 2ihb by Molmil](/molmil-images/mine/2ihb) | Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, MAGNESIUM ION, ... | Authors: | Soundararajan, M, Turnbull, A.P, Papagrigoriou, E, Pike, A.C.W, Bunkoczi, G, Ugochukwu, E, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | Deposit date: | 2006-09-26 | Release date: | 2006-11-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3IC3
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![BU of 3ic3 by Molmil](/molmil-images/mine/3ic3) | Structure of a putative pyruvate dehydrogenase from the photosynthetic bacterium Rhodopseudomonas palustrus CGA009 | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Cuff, M.E, Tesar, C, Jedrzejczak, R, Mckinlay, J.B, Harwood, C.S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-07-17 | Release date: | 2009-09-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of a putative pyruvate dehydrogenase from the photosynthetic bacterium Rhodopseudomonas palustrus CGA009 TO BE PUBLISHED
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2IJJ
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![BU of 2ijj by Molmil](/molmil-images/mine/2ijj) | Crystal structure analysis of ColE1 ROM mutant F14Y | Descriptor: | Regulatory protein rop | Authors: | Ladner, J.E. | Deposit date: | 2006-09-29 | Release date: | 2007-10-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | New crystal structures of ColE1 Rom and variants resulting from mutation of a surface exposed residue: Implications for RNA-recognition. Proteins, 72, 2008
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8FG7
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![BU of 8fg7 by Molmil](/molmil-images/mine/8fg7) | |
3O61
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![BU of 3o61 by Molmil](/molmil-images/mine/3o61) | Structure of the E100A E.coli GDP-mannose hydrolase (yffh) in complex with GDP-mannose and Mg++ | Descriptor: | CHLORIDE ION, GDP-mannose pyrophosphatase nudK, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... | Authors: | Amzel, L.M, Gabelli, S.B, Boto, A.N. | Deposit date: | 2010-07-28 | Release date: | 2011-05-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins, 79, 2011
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4DFB
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![BU of 4dfb by Molmil](/molmil-images/mine/4dfb) | Crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin | Descriptor: | APH(2")-Id, CHLORIDE ION, KANAMYCIN A | Authors: | Stogios, P.J, Minasov, G, Osipiuk, J, Evdokimova, E, Egorova, E, Di leo, R, Li, H, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-01-23 | Release date: | 2012-02-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A small molecule discrimination map of the antibiotic resistance kinome. Chem.Biol., 18, 2011
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3IEC
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![BU of 3iec by Molmil](/molmil-images/mine/3iec) | |
1JKG
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![BU of 1jkg by Molmil](/molmil-images/mine/1jkg) | Structural basis for the recognition of a nucleoporin FG-repeat by the NTF2-like domain of TAP-p15 mRNA nuclear export factor | Descriptor: | TAP, p15 | Authors: | Fribourg, S, Braun, I.C, Izaurralde, E, Conti, E. | Deposit date: | 2001-07-12 | Release date: | 2001-10-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol.Cell, 8, 2001
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8FG5
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![BU of 8fg5 by Molmil](/molmil-images/mine/8fg5) | Apo mouse acidic mammalian chitinase, catalytic domain at 100 K | Descriptor: | Acidic mammalian chitinase, MAGNESIUM ION | Authors: | Diaz, R.E, Correy, G.J, Young, I.D, Thompson, M.C, Fraser, J.S. | Deposit date: | 2022-12-12 | Release date: | 2023-03-01 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase. Biorxiv, 2024
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5BO2
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![BU of 5bo2 by Molmil](/molmil-images/mine/5bo2) | |
3NUE
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![BU of 3nue by Molmil](/molmil-images/mine/3nue) | The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with tryptophan | Descriptor: | CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M. | Deposit date: | 2010-07-06 | Release date: | 2010-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis J.Biol.Chem., 285, 2010
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6J7W
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![BU of 6j7w by Molmil](/molmil-images/mine/6j7w) | Crystal Structure of Human BCMA in complex with UniAb(TM) VH | Descriptor: | Tumor necrosis factor receptor superfamily member 17, UniAb | Authors: | Clarke, S.C, Ma, B, Trinklein, N.D, Schellenberger, U, Osborn, M, Ouisse, L, Boudreau, A, Davison, L, Harris, K.E, Ugamraj, H, Balasubramani, A, Dang, K, Jorgensen, B, Ogana, H, Pham, D, Pratap, P, Sankaran, P, Anegon, I, van Schooten, W, Bruggemann, M, Buelow, R, Force Aldred, S. | Deposit date: | 2019-01-18 | Release date: | 2019-02-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies Front Immunol, 9, 2018
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6J90
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![BU of 6j90 by Molmil](/molmil-images/mine/6j90) | Crystal Structure of GyraseB N-Terminal Domain complex with ATP from Salmonella Typhi at 2.2A Resolution | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kaur, G, Sachdeva, E, Tiwari, P, Gupta, D, Ethayathulla, A.S, Kaur, P. | Deposit date: | 2019-01-21 | Release date: | 2020-01-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of GyraseB N-Terminal Domain complex with ATP from Salmonella Typhi at 2.2A Resolution To Be Published
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6EUN
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![BU of 6eun by Molmil](/molmil-images/mine/6eun) | Crystal structure of Neisseria meningitidis vaccine antigen NadA variant 3 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... | Authors: | Dello Iacono, L, Liguori, A, Malito, E, Bottomley, M.J. | Deposit date: | 2017-10-30 | Release date: | 2018-10-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | NadA3 Structures Reveal Undecad Coiled Coils and LOX1 Binding Regions Competed by Meningococcus B Vaccine-Elicited Human Antibodies. MBio, 9, 2018
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8FJP
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![BU of 8fjp by Molmil](/molmil-images/mine/8fjp) | Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, salivary gland surface protein 1 | Authors: | Liu, S, Xia, X, Calvo, E, Zhou, Z.H. | Deposit date: | 2022-12-20 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. Nat Commun, 14, 2023
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3NY2
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![BU of 3ny2 by Molmil](/molmil-images/mine/3ny2) | Structure of the ubr-box of UBR2 ubiquitin ligase | Descriptor: | E3 ubiquitin-protein ligase UBR2, ZINC ION | Authors: | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | Deposit date: | 2010-07-14 | Release date: | 2010-08-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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1S6Q
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![BU of 1s6q by Molmil](/molmil-images/mine/1s6q) | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681 | Descriptor: | 4-[4-(2,4,6-TRIMETHYL-PHENYLAMINO)-PYRIMIDIN-2-YLAMINO]-BENZONITRILE, POL polyprotein [Contains: Reverse transcriptase] | Authors: | Das, K, Arnold, E. | Deposit date: | 2004-01-26 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants. J.Med.Chem., 47, 2004
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4KVD
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![BU of 4kvd by Molmil](/molmil-images/mine/4kvd) | Crystal structure of Aspergillus terreus aristolochene synthase complexed with (4aS,7S)-1,4a-dimethyl-7-(prop-1-en-2-yl)decahydroquinolin-1-ium | Descriptor: | (1R,4aS,7S,8aR)-1,4a-dimethyl-7-(prop-1-en-2-yl)decahydroquinolinium, Aristolochene synthase, GLYCEROL, ... | Authors: | Chen, M, Faraldos, J.A, Al-lami, N, Janvier, M, D'Antonio, E.L, Cane, D.E, Allemann, R.K, Christianson, D.W. | Deposit date: | 2013-05-22 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry, 52, 2013
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6MB7
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![BU of 6mb7 by Molmil](/molmil-images/mine/6mb7) | Binary (paromomycin) structure of AAC-IIIb | Descriptor: | Aac(3)-IIIb protein, PAROMOMYCIN | Authors: | Cuneo, M.J, Kumar, P. | Deposit date: | 2018-08-29 | Release date: | 2018-11-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Encoding of Promiscuity in an Aminoglycoside Acetyltransferase. J. Med. Chem., 61, 2018
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8FDG
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![BU of 8fdg by Molmil](/molmil-images/mine/8fdg) | |
6ESD
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![BU of 6esd by Molmil](/molmil-images/mine/6esd) | Crystal structure of L-tryptophan oxidase VioA from Chromobacterium violaceum | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Flavin-dependent L-tryptophan oxidase VioA | Authors: | Lai, H.E, Morgan, M, Moore, S, Freemont, P. | Deposit date: | 2017-10-20 | Release date: | 2017-12-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A semi-synthetic strategy for derivatization of the violacein natural product scaffold Biorxiv, 2017
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