3EDJ
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![BU of 3edj by Molmil](/molmil-images/mine/3edj) | Structural base for cyclodextrin hydrolysis | Descriptor: | CALCIUM ION, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Cyclomaltodextrinase, ... | Authors: | Buedenbender, S, Schulz, G.E. | Deposit date: | 2008-09-03 | Release date: | 2009-03-03 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural base for enzymatic cyclodextrin hydrolysis J.Mol.Biol., 385, 2009
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3E6N
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![BU of 3e6n by Molmil](/molmil-images/mine/3e6n) | Structure of murine INOS oxygenase domain with inhibitor AR-C125813 | Descriptor: | 4-METHYL-6-PROPYLPYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | Authors: | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | Deposit date: | 2008-08-15 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
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3NZL
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![BU of 3nzl by Molmil](/molmil-images/mine/3nzl) | Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B | Descriptor: | DNA-binding protein SATB1 | Authors: | Forouhar, F, Abashidze, M, Seetharaman, J, Kuzin, A.P, Patel, P, Xiao, R, Ciccosanti, C, Shastry, R, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-07-16 | Release date: | 2010-09-22 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (1.199 Å) | Cite: | Crystal Structure of the N-terminal domain of DNA-binding protein SATB1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4435B (CASP Target) To be Published
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3EAI
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![BU of 3eai by Molmil](/molmil-images/mine/3eai) | Structure of inhibited murine iNOS oxygenase domain | Descriptor: | 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | Authors: | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | Deposit date: | 2008-08-25 | Release date: | 2008-10-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
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3EDE
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![BU of 3ede by Molmil](/molmil-images/mine/3ede) | |
3EHU
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![BU of 3ehu by Molmil](/molmil-images/mine/3ehu) | |
3EPL
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![BU of 3epl by Molmil](/molmil-images/mine/3epl) | |
3NRZ
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![BU of 3nrz by Molmil](/molmil-images/mine/3nrz) | Crystal Structure of Bovine Xanthine Oxidase in Complex with Hypoxanthine | Descriptor: | DIOXOTHIOMOLYBDENUM(VI) ION, FE2/S2 (INORGANIC) CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Cao, H, Pauff, J.M, Hille, R. | Deposit date: | 2010-07-01 | Release date: | 2010-07-14 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Substrate orientation and catalytic specificity in the action of xanthine oxidase: the sequential hydroxylation of hypoxanthine to uric acid. J.Biol.Chem., 285, 2010
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3NXH
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![BU of 3nxh by Molmil](/molmil-images/mine/3nxh) | Crystal Structure of the transcriptional regulator yvhJ from Bacillus subtilis. Northeast Structural Genomics Consortium Target SR735. | Descriptor: | transcriptional regulator yvhJ | Authors: | Vorobiev, S, Chen, Y, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-07-13 | Release date: | 2010-08-04 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.584 Å) | Cite: | Crystal Structure of the transcriptional regulator yvhJ from Bacillus subtilis. To be Published
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3NRN
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![BU of 3nrn by Molmil](/molmil-images/mine/3nrn) | Crystal Structure of PF1083 protein from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR223 | Descriptor: | ADENOSINE MONOPHOSPHATE, uncharacterized protein PF1083 | Authors: | Seetharaman, J, Su, M, Patel, P, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-30 | Release date: | 2010-11-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Northeast Structural Genomics Consortium Target PfR223 To be Published
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3G2W
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![BU of 3g2w by Molmil](/molmil-images/mine/3g2w) | VHS Domain of human GGA1 complexed with a DXXLL hinge peptide | Descriptor: | ADP-ribosylation factor-binding protein GGA1, Internal peptide of the Hinge domain of ADP-ribosylation factor-binding protein GGA1 | Authors: | Cramer, J.F, Behrens, M.A, Gustafsen, C, Oliveira, C.L.P, Pedersen, J.S, Madsen, P, Petersen, C.M, Thirup, S.S. | Deposit date: | 2009-02-01 | Release date: | 2009-12-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | GGA autoinhibition revisited Traffic, 11, 2010
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3G3V
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![BU of 3g3v by Molmil](/molmil-images/mine/3g3v) | Crystal structure of spin labeled T4 Lysozyme (V131R1) at 291 K | Descriptor: | 2-HYDROXYETHYL DISULFIDE, AZIDE ION, CHLORIDE ION, ... | Authors: | Fleissner, M.R, Cascio, D, Hubbell, W.L. | Deposit date: | 2009-02-02 | Release date: | 2009-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural origin of weakly ordered nitroxide motion in spin-labeled proteins. Protein Sci., 18, 2009
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3GF2
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![BU of 3gf2 by Molmil](/molmil-images/mine/3gf2) | |
3GGL
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![BU of 3ggl by Molmil](/molmil-images/mine/3ggl) | X-Ray Structure of the C-terminal domain (277-440) of Putative chitobiase from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium Target BtR324A. | Descriptor: | DI(HYDROXYETHYL)ETHER, Putative chitobiase, ZINC ION | Authors: | Kuzin, A, Neely, H, Seetharaman, R, Lee, D, Ciccosanti, C, Foote, E.L, Janjua, H, Xiao, R, Nair, R, Rost, B, Acton, T, Everett, J.K, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-02-28 | Release date: | 2009-03-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Northeast Structural Genomics Consortium Target BtR324A To be Published
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3P51
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![BU of 3p51 by Molmil](/molmil-images/mine/3p51) | Three-dimensional structure of protein Q2Y8N9_NITMU from nitrosospira multiformis, Northeast structural genomics consortium target NMR118 | Descriptor: | Uncharacterized protein | Authors: | Kuzin, A, Chen, Y, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-10-07 | Release date: | 2010-10-27 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.056 Å) | Cite: | Northeast Structural Genomics Consortium Target NmR118 To be published
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3GB5
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![BU of 3gb5 by Molmil](/molmil-images/mine/3gb5) | Crystal structure of Mus musculus iodotyrosine deiodinase (IYD) bound to FMN | Descriptor: | ACETATE ION, FLAVIN MONONUCLEOTIDE, Iodotyrosine dehalogenase 1, ... | Authors: | Thomas, S.R, McTamney, P.M, Adler, J.M, LaRonde-LeBlanc, N, Rokita, S.E. | Deposit date: | 2009-02-18 | Release date: | 2009-05-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. J.Biol.Chem., 284, 2009
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3OUL
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![BU of 3oul by Molmil](/molmil-images/mine/3oul) | |
3OXZ
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![BU of 3oxz by Molmil](/molmil-images/mine/3oxz) | Crystal structure of ABL kinase domain bound with a DFG-out inhibitor AP24534 | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Tyrosine-protein kinase ABL1 | Authors: | Zhou, T, Huang, W.S, Wang, Y, Thomas, M, Keats, J, Xu, Q, Rivera, V, Shakespeare, W.C, Clackson, T, Dalgarno, D.C, Zhu, X. | Deposit date: | 2010-09-22 | Release date: | 2010-12-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Mechanism of the Pan-BCR-ABL Inhibitor Ponatinib (AP24534): Lessons for Overcoming Kinase Inhibitor Resistance. Chem.Biol.Drug Des., 77, 2011
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3GDN
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![BU of 3gdn by Molmil](/molmil-images/mine/3gdn) | Almond hydroxynitrile lyase in complex with benzaldehyde | Descriptor: | (2R)-hydroxy(phenyl)ethanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Dreveny, I, Gruber, K, Kratky, C. | Deposit date: | 2009-02-24 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Substrate binding in the FAD-dependent hydroxynitrile lyase from almond provides insight into the mechanism of cyanohydrin formation and explains the absence of dehydrogenation activity. Biochemistry, 48, 2009
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3GIK
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![BU of 3gik by Molmil](/molmil-images/mine/3gik) | Dpo4 extension ternary complex with the oxoG(anti)-C(anti) pair | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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3ESN
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![BU of 3esn by Molmil](/molmil-images/mine/3esn) | Human transthyretin (TTR) complexed with N-(3,5-Dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide | Descriptor: | N-(3,5-dibromo-4-hydroxyphenyl)-2,6-dimethylbenzamide, Transthyretin | Authors: | Connelly, S, Wilson, I.A. | Deposit date: | 2008-10-06 | Release date: | 2009-04-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 52, 2009
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3PE5
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![BU of 3pe5 by Molmil](/molmil-images/mine/3pe5) | Three-dimensional Structure of protein A7VV38_9CLOT from Clostridium leptum DSM 753, Northeast Structural Genomics Consortium Target QlR103 | Descriptor: | Uncharacterized protein | Authors: | Kuzin, A, Su, M, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Wang, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-10-25 | Release date: | 2010-11-10 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.381 Å) | Cite: | Northeast Structural Genomics Consortium Target QlR103 To be published
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3PE1
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![BU of 3pe1 by Molmil](/molmil-images/mine/3pe1) | Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945 | Descriptor: | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION | Authors: | Battistutta, R, Papinutto, E, Lolli, G, Pierre, F, Haddach, M, Ryckman, D.M. | Deposit date: | 2010-10-25 | Release date: | 2011-09-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50, 2011
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3OH8
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![BU of 3oh8 by Molmil](/molmil-images/mine/3oh8) | Crystal structure of the nucleoside-diphosphate sugar epimerase from Corynebacterium glutamicum. Northeast Structural Genomics Consortium Target CgR91 | Descriptor: | Nucleoside-diphosphate sugar epimerase (SulA family) | Authors: | Vorobiev, S, Lew, S, Kuzin, A, Mao, M, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-08-17 | Release date: | 2010-09-01 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.997 Å) | Cite: | Crystal structure of the nucleoside-diphosphate sugar epimerase from Corynebacterium glutamicum. Northeast Structural Genomics Consortium Target CgR91. To be Published
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3OAU
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![BU of 3oau by Molmil](/molmil-images/mine/3oau) | Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Non-Domain-Exchanged Forms, but only binds the HIV-1 Glycan Shield if Domain-Exchanged | Descriptor: | Fab 2G12, heavy chain, light chain, ... | Authors: | Doores, K.J, Fulton, Z, Huber, M, Wilson, I.A, Burton, D.R. | Deposit date: | 2010-08-05 | Release date: | 2011-01-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged. J.Virol., 84, 2010
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