3PE1
Crystal structure of human protein kinase CK2 alpha subunit in complex with the inhibitor CX-4945
Summary for 3PE1
Entry DOI | 10.2210/pdb3pe1/pdb |
Related | 3FL5 3PE2 |
Descriptor | Casein kinase II subunit alpha, 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, ck2-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40878.86 |
Authors | Battistutta, R.,Papinutto, E.,Lolli, G.,Pierre, F.,Haddach, M.,Ryckman, D.M. (deposition date: 2010-10-25, release date: 2011-09-07, Last modification date: 2023-09-06) |
Primary citation | Battistutta, R.,Cozza, G.,Pierre, F.,Papinutto, E.,Lolli, G.,Sarno, S.,O'Brien, S.E.,Siddiqui-Jain, A.,Haddach, M.,Anderes, K.,Ryckman, D.M.,Meggio, F.,Pinna, L.A. Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50:8478-8488, 2011 Cited by PubMed: 21870818DOI: 10.1021/bi2008382 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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