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6BRB
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BU of 6brb by Molmil
Novel non-antibody protein scaffold targeting CD40L
Descriptor: CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.
Sci Transl Med, 11, 2019
5XWT
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BU of 5xwt by Molmil
Crystal structure of PTPdelta Ig1-Fn1 in complex with SALM5 LRR-Ig
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S.
Deposit date:2017-06-30
Release date:2018-06-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (4.178 Å)
Cite:Structural basis of trans-synaptic interactions between PTP delta and SALMs for inducing synapse formation.
Nat Commun, 9, 2018
5X83
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BU of 5x83 by Molmil
Structure of DCC FN456 domains
Descriptor: Netrin receptor DCC
Authors:Finci, F.I, Xiao, J, Wang, J.
Deposit date:2017-02-28
Release date:2017-09-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.997 Å)
Cite:Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC
Protein Cell, 8, 2017
5UTK
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BU of 5utk by Molmil
Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2 (Tie2[FNIIIa-c])
Descriptor: Angiopoietin-1 receptor
Authors:Moore, J.O, Lemmon, M.A, Ferguson, K.M.
Deposit date:2017-02-15
Release date:2017-04-12
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5N48
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BU of 5n48 by Molmil
Structure of Anticalin N9B in complex with extra-domain B of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
5N47
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BU of 5n47 by Molmil
Structure of Anticalin N7E in complex with the three-domain fragment Fn7B8 of human oncofetal fibronectin
Descriptor: Fibronectin, Neutrophil gelatinase-associated lipocalin
Authors:Schiefner, A, Skerra, A.
Deposit date:2017-02-10
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Anticalins Reveal High Plasticity in the Mode of Complex Formation with a Common Tumor Antigen.
Structure, 26, 2018
5N06
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BU of 5n06 by Molmil
Crystal structure of Tie1 Fibronectin-like domain 3
Descriptor: Tyrosine-protein kinase receptor Tie-1
Authors:Leppanen, V.-M, Saharinen, P, Alitalo, K.
Deposit date:2017-02-02
Release date:2017-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MYA
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BU of 5mya by Molmil
Homodimerization of Tie2 Fibronectin-like domains 1-3 in space group C2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ...
Authors:Leppanen, V.-M, Saharinen, P, Alitalo, K.
Deposit date:2017-01-26
Release date:2017-04-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5MYB
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BU of 5myb by Molmil
Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ...
Authors:Leppanen, V.-M, Saharinen, P, Alitalo, K.
Deposit date:2017-01-26
Release date:2017-04-26
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5M0A
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BU of 5m0a by Molmil
Solution structure of isolated 15th Fibronectin III domain from human fibronectin
Descriptor: Fibronectin
Authors:Waltho, J.P, Cliff, M.J, Blumson, E, Humphries, M.
Deposit date:2016-10-04
Release date:2017-11-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution structure of isolated 15th Fibronectin III domain from human fibronectin
To Be Published
5LKN
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BU of 5lkn by Molmil
NMR solution structure of human FNIII domain 2 of NCAM
Descriptor: Neural cell adhesion molecule 1
Authors:Slapsak, U, Salzano, G, Amin, L, Abskharon, R.N.N, Ilc, G, Zupancic, B, Biljan, I, Plavec, J, Giachin, G, Legname, G.
Deposit date:2016-07-22
Release date:2016-09-14
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.
J.Biol.Chem., 291, 2016
5KF4
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BU of 5kf4 by Molmil
Crystal structure of FN3 domain (Residues P368-P466) of Human collagen XX
Descriptor: Collagen alpha-1(XX) chain
Authors:Xie, Y, Cheng, Z, Zhao, J.
Deposit date:2016-06-12
Release date:2016-07-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the second fibronectin type III (FN3) domain from human collagen alpha 1 type XX
Acta Crystallogr F Struct Biol Commun, 73, 2017
5J7C
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BU of 5j7c by Molmil
A picomolar affinity FN3 domain in complex with hen egg-white lysozyme
Descriptor: FNfn10-anti-lysozyme (DE0.4.1), Lysozyme C
Authors:Porebski, B.T, Drinkwater, N, McGowan, S, Buckle, A.M.
Deposit date:2016-04-06
Release date:2016-08-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.535 Å)
Cite:Circumventing the stability-function trade-off in an engineered FN3 domain.
Protein Eng.Des.Sel., 2016
5J6Z
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BU of 5j6z by Molmil
Structure of anastellin bound to beta-strands A and B from the third type III domain of fibronectin
Descriptor: Anastellin, Fibronectin
Authors:Stine, J.M, Briknarova, K.
Deposit date:2016-04-05
Release date:2017-04-12
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Interaction between the Third Type III Domain from Fibronectin and Anastellin Involves beta-Strand Exchange.
Biochemistry, 56, 2017
5J11
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BU of 5j11 by Molmil
Structure of human TSLP in complex with TSLPR and IL-7Ralpha
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor-like factor 2, Interleukin-7 receptor subunit alpha, ...
Authors:Verstraete, K, Savvides, S.N.
Deposit date:2016-03-28
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Nat Commun, 8, 2017
5I99
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BU of 5i99 by Molmil
Crystal structure of mouse CNTN3 Ig5-Fn2 domains
Descriptor: Contactin-3, GLYCEROL
Authors:Nikolaienko, R.M, Bouyain, S.
Deposit date:2016-02-19
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
J.Biol.Chem., 291, 2016
5FN8
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BU of 5fn8 by Molmil
Crystal structure of rat CD45 extracellular region, domains d3-d4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
Authors:Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J.
Deposit date:2015-11-11
Release date:2016-03-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
5FMV
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BU of 5fmv by Molmil
Crystal structure of human CD45 extracellular region, domains d1-d4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C, SULFATE ION
Authors:Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J.
Deposit date:2015-11-09
Release date:2016-03-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
5FM8
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BU of 5fm8 by Molmil
Structure of the C-terminally extended domain My4 of human myomesin (space group P65)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MYOMESIN-1, NICKEL (II) ION
Authors:Pernigo, S, Steiner, R.A.
Deposit date:2015-11-02
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.
Structure, 25, 2017
5FM5
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BU of 5fm5 by Molmil
Crystal structure of the myomesin:obscurin-like-1 complex
Descriptor: MYOMESIN-1, OBSCURIN-LIKE-1
Authors:Pernigo, S, Steiner, R.A.
Deposit date:2015-11-01
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.
Structure, 25, 2017
5FM4
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BU of 5fm4 by Molmil
Structure of the C-terminally extended domain My4 of human myomesin (space group P21)
Descriptor: MYOMESIN-1
Authors:Pernigo, S, Steiner, R.A.
Deposit date:2015-10-30
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.
Structure, 25, 2017
5E7L
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BU of 5e7l by Molmil
Crystal structure of mouse CNTN2 FN1-FN3 domains
Descriptor: Contactin-2
Authors:Nikolaienko, R.M, Bouyain, S.
Deposit date:2015-10-12
Release date:2016-08-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
J.Biol.Chem., 291, 2016
5E53
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BU of 5e53 by Molmil
Crystal structure of chicken CNTN1 FN1-FN3 domains
Descriptor: Contactin-1, IMIDAZOLE
Authors:Nikolaienko, R.M, Bouyain, S.
Deposit date:2015-10-07
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
J.Biol.Chem., 291, 2016
5E55
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BU of 5e55 by Molmil
Crystal structure of mouse CNTN6 FN1-FN3 domains
Descriptor: Contactin-6
Authors:Nikolaienko, R.M, Bouyain, S.
Deposit date:2015-10-07
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
J.Biol.Chem., 291, 2016
5E4S
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BU of 5e4s by Molmil
Crystal structure of mouse CNTN4 FN1-FN3 domains
Descriptor: Contactin-4
Authors:Nikolaienko, R.M, Bouyain, S.
Deposit date:2015-10-07
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
J.Biol.Chem., 291, 2016

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