1I33
| LEISHMANIA MEXICANA GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE IN COMPLEX WITH INHIBITORS | Descriptor: | GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, N-1,2,3,4-TETRAHYDRONAPHTH-1-YL-2'-[3,5-DIMETHOXYBENZAMIDO]-2'-DEOXY-ADENOSINE | Authors: | Suresh, S, Bressi, J.C, Kennedy, K.J, Verlinde, C.L.M.J, Gelb, M.H, Hol, W.G.J. | Deposit date: | 2001-02-12 | Release date: | 2001-10-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. J.Mol.Biol., 309, 2001
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2Y0M
| CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN DOSAGE COMPENSATION FACTORS MSL1 AND MOF | Descriptor: | ACETYL COENZYME *A, MALE-SPECIFIC LETHAL 1 HOMOLOG, PROBABLE HISTONE ACETYLTRANSFERASE MYST1, ... | Authors: | Kadlec, J, Hallacli, E, Lipp, M, Holz, H, Sanchez Weatherby, J, Cusack, S, Akhtar, A. | Deposit date: | 2010-12-03 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Mof and Msl3 Recruitment Into the Dosage Compensation Complex by Msl1. Nat.Struct.Mol.Biol., 18, 2011
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4F80
| Crystal Structure of the human BTN3A1 ectodomain | Descriptor: | Butyrophilin subfamily 3 member A1 | Authors: | Palakodeti, A, Sandstrom, A, Sundaresan, L, Harly, C, Nedellec, S, Olive, D, Scotet, E, Bonneville, M, Adams, E.J. | Deposit date: | 2012-05-16 | Release date: | 2012-08-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.944 Å) | Cite: | The molecular basis for modulation of human V(gamma)9V(delta)2 T cell responses by CD277/Butyrophilin-3 (BTN3A)-specific antibodies J.Biol.Chem., 287, 2012
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1I73
| COMPLEX OF PRO-LEU-L-TRP PHOSPHONATE WITH THE CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | Descriptor: | CALCIUM ION, NEUTROPHIL COLLAGENASE, THREE RESIDUE PEPTIDE INHIBITOR, ... | Authors: | Gavuzzo, E, Pochetti, G, Mazza, F, Gallina, C, Gorini, B, D'Alessio, S, Pieper, M, Tschesche, H, Tucker, P.A. | Deposit date: | 2001-03-07 | Release date: | 2001-03-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J.Med.Chem., 43, 2000
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8EKE
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1IBI
| QUAIL CYSTEINE AND GLYCINE-RICH PROTEIN, NMR, 15 MINIMIZED MODEL STRUCTURES | Descriptor: | CYSTEINE-RICH PROTEIN 2, ZINC ION | Authors: | Schuler, W, Kloiber, K, Matt, T, Bister, K, Konrat, R. | Deposit date: | 2001-03-28 | Release date: | 2001-09-05 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Application of cross-correlated NMR spin relaxation to the zinc-finger protein CRP2(LIM2): evidence for collective motions in LIM domains. Biochemistry, 40, 2001
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4FQZ
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1ICH
| SOLUTION STRUCTURE OF THE TUMOR NECROSIS FACTOR RECEPTOR-1 DEATH DOMAIN | Descriptor: | TUMOR NECROSIS FACTOR RECEPTOR-1 | Authors: | Sukits, S.F, Lin, L.-L, Malakian, K, Powers, R, Xu, G.-Y. | Deposit date: | 2001-04-01 | Release date: | 2002-04-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the tumor necrosis factor receptor-1 death domain. J.Mol.Biol., 310, 2001
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4FR3
| Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilizer 16-O-Me-FC-H | Descriptor: | (4R,5R,6R,6aS,9S,9aE,10aR)-5-hydroxy-9-(methoxymethyl)-6,10a-dimethyl-3-(propan-2-yl)-1,2,4,5,6,6a,7,8,9,10a-decahydrodicyclopenta[a,d][8]annulen-4-yl alpha-D-glucopyranoside, 14-3-3 protein sigma, MAGNESIUM ION, ... | Authors: | Ottmann, C, Anders, C, Schumacher, B. | Deposit date: | 2012-06-26 | Release date: | 2013-05-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface. Chem.Biol., 20, 2013
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1IBO
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1IC6
| STRUCTURE OF A SERINE PROTEASE PROTEINASE K FROM TRITIRACHIUM ALBUM LIMBER AT 0.98 A RESOLUTION | Descriptor: | CALCIUM ION, NITRATE ION, PROTEINASE K | Authors: | Betzel, C, Gourinath, S, Kumar, P, Kaur, P, Perbandt, M, Eschenburg, S, Singh, T.P. | Deposit date: | 2001-03-30 | Release date: | 2001-04-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (0.98 Å) | Cite: | Structure of a serine protease proteinase K from Tritirachium album limber at 0.98 A resolution. Biochemistry, 40, 2001
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2Y0N
| CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN DOSAGE COMPENSATION FACTORS MSL1 AND MSL3 | Descriptor: | MALE-SPECIFIC LETHAL 1 HOMOLOG, MALE-SPECIFIC LETHAL 3 HOMOLOG | Authors: | Kadlec, J, Hallacli, E, Lipp, M, Holz, H, Sanchez Weatherby, J, Cusack, S, Akhtar, A. | Deposit date: | 2010-12-04 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for Mof and Msl3 Recruitment Into the Dosage Compensation Complex by Msl1. Nat.Struct.Mol.Biol., 18, 2011
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4F0Z
| Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L | Descriptor: | Ankyrin repeat domain-containing protein A238L, CALCIUM ION, Calcineurin subunit B type 1, ... | Authors: | Grigoriu, S, Peti, W, Page, R. | Deposit date: | 2012-05-05 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. Plos Biol., 11, 2013
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4F11
| Crystal structure of the extracellular domain of human GABA(B) receptor GBR2 | Descriptor: | Gamma-aminobutyric acid type B receptor subunit 2 | Authors: | Geng, Y, Xiong, D, Mosyak, L, Malito, D.L, Kniazeff, J, Chen, Y, Burmakina, S, Quick, M, Bush, M, Javitch, J.A, Pin, J.-P, Fan, Q.R. | Deposit date: | 2012-05-05 | Release date: | 2012-06-06 | Last modified: | 2012-08-15 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nat.Neurosci., 15, 2012
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1ICC
| RAT OUTER MITOCHONDRIAL MEMBRANE CYTOCHROME B5 | Descriptor: | CYTOCHROME B5 OUTER MITOCHONDRIAL MEMBRANE ISOFORM, MAGNESIUM ION, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Terzyan, S, Zhang, X. | Deposit date: | 2001-03-30 | Release date: | 2001-09-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5. Biochemistry, 40, 2001
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4F6R
| Tubulin:Stathmin-like domain complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Designed ankyrin repeat protein (DARPIN) D2, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Gigant, B, Mignot, I, Knossow, M. | Deposit date: | 2012-05-15 | Release date: | 2012-07-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Design and characterization of modular scaffolds for tubulin assembly. J.Biol.Chem., 287, 2012
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2Y41
| Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN | Descriptor: | 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MANGANESE (II) ION | Authors: | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | Deposit date: | 2011-01-04 | Release date: | 2011-01-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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4F9G
| Crystal structure of STING complex with Cyclic di-GMP. | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Transmembrane protein 173 | Authors: | Kabaleeswaran, V, Wu, H. | Deposit date: | 2012-05-18 | Release date: | 2012-07-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING. Mol.Cell, 46, 2012
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4FCR
| Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization | Descriptor: | 2-{[4-(2-chloro-4,5-dimethoxyphenyl)-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-2-yl]sulfanyl}-N,N-dimethylacetamide, Heat shock protein HSP 90-alpha | Authors: | Davies, N.G, Browne, H, Davis, B, Foloppe, N, Geoffrey, S, Gibbons, B, Hart, T, Drysdale, M.J, Mansell, H, Massey, A, Matassova, N, Moore, J.D, Murray, J, Pratt, R, Ray, S, Roughley, S.D, Jensen, M.R, Schoepfer, J, Scriven, K, Simmonite, H, Stokes, S, Surgenor, A, Webb, P, Wright, L, Brough, P. | Deposit date: | 2012-05-25 | Release date: | 2012-10-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.698 Å) | Cite: | Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. Bioorg.Med.Chem., 20, 2012
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1I76
| COMPLEX OF 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID (D-TIC DERIVATIVE) WITH T CATALITIC DOMAIN OF MATRIX METALLO PROTEINASE-8 (MET80 FORM) | Descriptor: | 2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID, CALCIUM ION, NEUTROPHIL COLLAGENASE, ... | Authors: | Gavuzzo, E, Pochetti, G, Mazza, F, Gallina, C, Gorini, B, D'Alessio, S, Pieper, M, Tschesche, H, Tucker, P.A. | Deposit date: | 2001-03-08 | Release date: | 2001-03-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J.Med.Chem., 43, 2000
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8ESV
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2Y42
| Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with NADH and Mn | Descriptor: | 3-ISOPROPYLMALATE DEHYDROGENASE, BICINE, MANGANESE (II) ION, ... | Authors: | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | Deposit date: | 2011-01-04 | Release date: | 2011-01-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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4FDU
| Crystal Structure of a Multiple Inositol Polyphosphate Phosphatase | Descriptor: | 1,2-ETHANEDIOL, D-MYO-INOSITOL-HEXASULPHATE, Putative multiple inositol polyphosphate histidine phosphatase 1 | Authors: | Li, A.W.H, Hemmings, A.M. | Deposit date: | 2012-05-29 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | A Bacterial Homolog of a Eukaryotic Inositol Phosphate Signaling Enzyme Mediates Cross-kingdom Dialog in the Mammalian Gut. Cell Rep, 6, 2014
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4FGD
| Structure of the effector protein Tse1 from Pseudomonas aeruginosa, selenomethionine variant | Descriptor: | CHLORIDE ION, THIOCYANATE ION, Tse1 | Authors: | Benz, J, Sendlmeier, C, Barends, T.R.M, Meinhart, A. | Deposit date: | 2012-06-04 | Release date: | 2012-06-20 | Last modified: | 2012-07-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Insights into the Effector - Immunity System Tse1/Tsi1 from Pseudomonas aeruginosa. Plos One, 7, 2012
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2Y46
| Structure of the mixed-function P450 MycG in complex with mycinamicin IV in C 2 2 21 space group | Descriptor: | BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... | Authors: | Li, S, Kells, P.M, Sherman, D.H, Podust, L.M. | Deposit date: | 2011-01-05 | Release date: | 2012-01-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012
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