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8PJ3
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BU of 8pj3 by Molmil
Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3)
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Petrychenko, V, Yi, S.-H, Liedtke, D, Peng, B.Z, Rodnina, M.V, Fischer, N.
Deposit date:2023-06-22
Release date:2024-08-14
Last modified:2024-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for translational control by the human 48S initiation complex.
Nat.Struct.Mol.Biol., 2024
7ZUW
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BU of 7zuw by Molmil
Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R.
Deposit date:2022-05-13
Release date:2023-02-22
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
7ZPQ
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BU of 7zpq by Molmil
Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1)
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R.
Deposit date:2022-04-28
Release date:2023-02-22
Last modified:2024-07-24
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
8P85
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BU of 8p85 by Molmil
80S yeast ribosome in complex with Fluorolissoclimide
Descriptor: (2~{S})-2-azanylpropanal, 16S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Terrosu, S, Yusupov, M.
Deposit date:2023-08-31
Release date:2025-06-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Role of Protein eL42 in the Ribosome Binding of Synthetic Analogues of Natural Lissoclimides
To Be Published
8PNN
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BU of 8pnn by Molmil
80S yeast ribosome in complex with Bromolissoclimide
Descriptor: (3~{R})-3-[(1~{S})-2-[(1~{R},3~{S},4~{a}~{S},7~{S},8~{a}~{S})-7-bromanyl-5,5,8~{a}-trimethyl-2-methylidene-3-oxidanyl-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione, 16S ribosomal RNA, 25S ribosomal RNA, ...
Authors:Terrosu, S, Yusupov, M.
Deposit date:2023-06-30
Release date:2025-05-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding.
Acs Chem.Biol., 20, 2025
6YLM
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BU of 6ylm by Molmil
mCherry
Descriptor: CHLORIDE ION, mCherry
Authors:Myskova, J, Rybakova, M, Brynda, J, Lazar, J.
Deposit date:2020-04-07
Release date:2020-12-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Directionality of light absorption and emission in representative fluorescent proteins.
Proc.Natl.Acad.Sci.USA, 117, 2020
7ZHG
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BU of 7zhg by Molmil
High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop
Descriptor: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:Kazan, R, Bourgeois, G, Mechulam, Y, Coureux, P.D, Schmitt, E.
Deposit date:2022-04-06
Release date:2022-06-29
Last modified:2025-07-09
Method:ELECTRON MICROSCOPY (2.25 Å)
Cite:Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
8CRG
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BU of 8crg by Molmil
E. coli adenylate kinase in complex with two ADP molecules as a result of enzymatic AP4A hydrolysis
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase
Authors:Oelker, M, Tischlik, S, Wolf-Watz, M, Sauer-Eriksson, A.E.
Deposit date:2023-03-08
Release date:2023-06-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Insights into Enzymatic Catalysis from Binding and Hydrolysis of Diadenosine Tetraphosphate by E. coli Adenylate Kinase.
Biochemistry, 62, 2023
7MDZ
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BU of 7mdz by Molmil
80S rabbit ribosome stalled with benzamide-CHX
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S21, ...
Authors:Koga, Y, Hoang, E.M, Park, Y, Keszei, A.F.A, Murray, J, Shao, S, Liau, B.B.
Deposit date:2021-04-06
Release date:2021-09-01
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.
J.Am.Chem.Soc., 143, 2021
7ZJX
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BU of 7zjx by Molmil
Rabbit 80S ribosome programmed with SECIS and SBP2
Descriptor: 18S rRNA, 28S rRNA, 40S Ribosomal protein eS19, ...
Authors:Hilal, T, Simonovic, M, Spahn, C.M.T.
Deposit date:2022-04-12
Release date:2022-09-07
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon.
Science, 376, 2022
7MJ1
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BU of 7mj1 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with NAD
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (3.402 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
5FGF
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BU of 5fgf by Molmil
Yeast 20S proteasome beta5-H(-2)A-T1A-K81R triple mutant in complex with Carfilzomib
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Huber, E.M, Groll, M.
Deposit date:2015-12-20
Release date:2016-03-23
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7, 2016
7MJ0
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BU of 7mj0 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with adenosine monophosphate AMP
Descriptor: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7MJ2
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BU of 7mj2 by Molmil
LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with Zn
Descriptor: MAGNESIUM ION, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase, ZINC ION
Authors:Chatterjee, S, Rankin, J.A, Lagishetty, S, Hu, J, Hausinger, R.P.
Deposit date:2021-04-19
Release date:2021-09-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The LarB carboxylase/hydrolase forms a transient cysteinyl-pyridine intermediate during nickel-pincer nucleotide cofactor biosynthesis.
Proc.Natl.Acad.Sci.USA, 118, 2021
7Z3N
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BU of 7z3n by Molmil
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation
Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ...
Authors:Kisonaite, M, Wild, K, Sinning, I.
Deposit date:2022-03-02
Release date:2023-04-12
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Nat.Struct.Mol.Biol., 30, 2023
7Z3O
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BU of 7z3o by Molmil
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation
Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ...
Authors:Kisonaite, M, Wild, K, Sinning, I.
Deposit date:2022-03-02
Release date:2023-04-12
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Nat.Struct.Mol.Biol., 30, 2023
8P09
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BU of 8p09 by Molmil
48S late-stage initiation complex with non methylated mRNA
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y.
Deposit date:2023-05-09
Release date:2024-03-20
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
8P03
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BU of 8p03 by Molmil
48S late-stage initiation complex with m6A mRNA
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y.
Deposit date:2023-05-09
Release date:2024-03-20
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Mol.Cell, 84, 2024
6Y09
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BU of 6y09 by Molmil
Crystal structure of Atg16L in complex with GTP-bound Rab33B (Q92L)
Descriptor: 1,2-ETHANEDIOL, Autophagy-related protein 16-1, DI(HYDROXYETHYL)ETHER, ...
Authors:Pantoom, S, Wu, Y.W.
Deposit date:2020-02-07
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein.
Autophagy, 17, 2021
8OVJ
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BU of 8ovj by Molmil
CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN
Descriptor: 40S ribosomal protein S12, 40S ribosomal protein S14, 40S ribosomal protein S19-like protein, ...
Authors:Rajan, K.S, Yonath, A.
Deposit date:2023-04-26
Release date:2024-05-08
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Cell Rep, 43, 2024
6HCM
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BU of 6hcm by Molmil
Structure of the rabbit collided di-ribosome (stalled monosome)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ...
Authors:Juszkiewicz, S, Chandrasekaran, V, Lin, Z, Kraatz, S, Ramakrishnan, V, Hegde, R.S.
Deposit date:2018-08-15
Release date:2018-10-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:ZNF598 Is a Quality Control Sensor of Collided Ribosomes.
Mol. Cell, 72, 2018
8CQW
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BU of 8cqw by Molmil
Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B
Descriptor: 18S, 25S, 3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2'S,3a'R,4''S,5''R,6'S,7a'S)-5''-methyl-4''-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3'-[1]benzofuran-2',2''-pyran]-6'-yl]carbonyl}-beta-D-glucopyranose, ...
Authors:Kolosova, O, Zgadzay, Y, Yusupov, M.
Deposit date:2023-03-07
Release date:2024-09-18
Last modified:2025-04-30
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Mechanism of read-through enhancement by aminoglycosides and mefloquine
Proc.Natl.Acad.Sci.USA, 2025
5FCJ
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BU of 5fcj by Molmil
Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
Authors:Mailliot, J, Garreau de Loubresse, N, Yusupova, G, Dinman, J.D, Yusupov, M.
Deposit date:2015-12-15
Release date:2016-05-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency.
J.Mol.Biol., 428, 2016
5FLX
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BU of 5flx by Molmil
Mammalian 40S HCV-IRES complex
Descriptor: 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ...
Authors:Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T.
Deposit date:2015-10-28
Release date:2015-12-23
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Embo J., 34, 2015
8OVE
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BU of 8ove by Molmil
CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant
Descriptor: 40S ribosomal protein L14, putative, 40S ribosomal protein S10, ...
Authors:Rajan, K.S, Yonath, A.
Deposit date:2023-04-25
Release date:2023-11-29
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Nat Commun, 14, 2023

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