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3WK3	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester Descriptor: 6-(ethoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fujihashi, M, Pai, E.F, Miki, K. Deposit date: 2013-10-17 Release date: 2013-12-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3W3K	Crystal structure of human TLR8 in complex with CL075 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ... Authors: Tanji, H, Ohto, U, Shimizu, T. Deposit date: 2012-12-22 Release date: 2013-04-03 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands Science, 339, 2013
3WF3	Crystal structure of human beta-galactosidase mutant I51T in complex with Galactose Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactosidase, ... Authors: Suzuki, H, Ohto, U, Shimizu, T. Deposit date: 2013-07-16 Release date: 2014-04-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural basis of pharmacological chaperoning for human beta-galactosidase to be published
3WCO	Crystal structure of the depentamerized mutant of N-terminal truncated selenocysteine synthase SelA Descriptor: L-seryl-tRNA(Sec) selenium transferase, THIOSULFATE Authors: Itoh, Y, Sekine, S, Yokoyama, S. Deposit date: 2013-05-29 Release date: 2014-01-22 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Dimer-Dimer Interaction of the Bacterial Selenocysteine Synthase SelA Promotes Functional Active-Site Formation and Catalytic Specificity J.Mol.Biol., 426, 2014
3WK0	Wild-type orotidine 5'-monophosphate decarboxylase from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester Descriptor: 6-(methoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fujihashi, M, Pai, E.F, Miki, K. Deposit date: 2013-10-17 Release date: 2013-12-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3W3N	Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 3 Descriptor: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... Authors: Tanji, H, Ohto, U, Shimizu, T. Deposit date: 2012-12-22 Release date: 2013-04-03 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands Science, 339, 2013
3W9G	Crystal structure of the ankyrin repeat domain of chicken TRPV4 Descriptor: Vanilloid receptor-related osmotically activated channel protein Authors: Itoh, Y, Hamada-nakahara, S, Suetsugu, S. Deposit date: 2013-04-04 Release date: 2014-04-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2 Nat Commun, 5, 2014
3WAX	Crystal Structure of Autotaxin in Complex with 3BoA Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2013-05-09 Release date: 2013-07-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.899 Å) Cite: Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
3WAY	Crystal Structure of Autotaxin in Complex with 4BoA Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2013-05-09 Release date: 2013-07-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.746 Å) Cite: Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
3WF2	Crystal structure of human beta-galactosidase in complex with NBT-DGJ Descriptor: (2R,3S,4R,5S)-N-butyl-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carbothioamide, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Suzuki, H, Ohto, U, Shimizu, T. Deposit date: 2013-07-16 Release date: 2014-04-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of pharmacological chaperoning for human beta-galactosidase to be published
3WAV	Crystal Structure of Autotaxin in Complex with Compound 10 Descriptor: (5Z)-5-(3,4-dichlorobenzylidene)-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4(5H)-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2013-05-09 Release date: 2013-07-31 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.797 Å) Cite: Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8, 2013
3WF0	Crystal structure of human beta-galactosidase in complex with 6S-NBI-DGJ Descriptor: (3Z,6S,7R,8S,8aS)-3-(butylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-6,7,8-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Suzuki, H, Ohto, U, Shimizu, T. Deposit date: 2013-07-16 Release date: 2014-04-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural basis of pharmacological chaperoning for human beta-galactosidase to be published
3WK2	Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate methyl ester Descriptor: 6-(methoxycarbonyl)uridine 5'-(dihydrogen phosphate), GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fujihashi, M, Pai, E.F, Miki, K. Deposit date: 2013-10-17 Release date: 2013-12-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J.Am.Chem.Soc., 135, 2013
3WPH	Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ... Authors: Ohto, U, Shimizu, T. Deposit date: 2014-01-11 Release date: 2015-02-11 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.327 Å) Cite: Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 Nature, 520, 2015
3WVG	Time-Resolved Crystal Structure of HindIII with 0sec soaking Descriptor: DNA (5'-D(*GP*CP*CP*AP*AP*GP*CP*TP*TP*GP*GP*C)-3'), GLYCEROL, SODIUM ION, ... Authors: Kawamura, T, Kobayashi, T, Watanabe, N. Deposit date: 2014-05-21 Release date: 2015-04-08 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Analysis of the HindIII-catalyzed reaction by time-resolved crystallography Acta Crystallogr.,Sect.D, 71, 2015
3WQP	Crystal structure of Rubisco T289D mutant from Thermococcus kodakarensis Descriptor: 1,2-ETHANEDIOL, 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Fujihashi, M, Nishitani, Y, Kiriyama, T, Miki, K. Deposit date: 2014-01-29 Release date: 2015-02-04 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Mutation design of thermophilic Rubisco based on the three-dimensional structure enhances its activity at ambient temperature to be published
3WVK	Time-Resolved Crystal Structure of HindIII with 230sec soaking Descriptor: DNA (5'-D(*GP*CP*CP*A)-3'), DNA (5'-D(*GP*CP*CP*AP*AP*GP*CP*TP*TP*GP*GP*C)-3'), DNA (5'-D(P*AP*GP*CP*TP*TP*GP*GP*C)-3'), ... Authors: Kawamura, T, Kobayashi, T, Watanabe, N. Deposit date: 2014-05-22 Release date: 2015-04-08 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Analysis of the HindIII-catalyzed reaction by time-resolved crystallography Acta Crystallogr.,Sect.D, 71, 2015
3X1U	Crystal structure of nucleosome core particle in the presence of histone variants involved in reprogramming Descriptor: CHLORIDE ION, DNA (146-MER), Histone H2A, ... Authors: Sivaraman, P, Kumarevel, T.S. Deposit date: 2014-11-28 Release date: 2015-09-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.25 Å) Cite: Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming. Biochem.Biophys.Res.Commun., 464, 2015
4OO9	Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mavoglurant, Metabotropic glutamate receptor 5, ... Authors: Dore, A.S, Okrasa, K, Patel, J.C, Serrano-Vega, M, Bennett, K, Cooke, R.M, Errey, J.C, Jazayeri, A, Khan, S, Tehan, B, Weir, M, Wiggin, G.R, Marshall, F.H. Deposit date: 2014-01-31 Release date: 2014-07-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature, 511, 2014
4OU3	Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... Authors: Liu, C, Yang, Y, Chen, L, Lin, Y.-L, Li, F. Deposit date: 2014-02-14 Release date: 2014-11-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy. J.Biol.Chem., 289, 2014
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
3UCK	Coccomyxa beta-carbonic anhydrase in complex with phosphate Descriptor: CHLORIDE ION, Carbonic anhydrase, PHOSPHATE ION, ... Authors: Huang, S, Hainzl, T, Sauer-Eriksson, A.E. Deposit date: 2011-10-27 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
4OON	Crystal structure of PBP1a in complex with compound 17 ((4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid) Descriptor: (4Z,8S,11E,14S)-5-(2-amino-1,3-thiazol-4-yl)-14-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-8-formyl-2-methyl-6-oxo-3,10-dioxa-4,7,11-triazatetradeca-4,11-diene-2,12,14-tricarboxylic acid, Penicillin-binding protein 1A Authors: Han, S, Caspers, N, Knafels, J.D. Deposit date: 2014-02-03 Release date: 2014-05-07 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. J.Med.Chem., 57, 2014
3UGU	Crystal Structure of p44 (Splice Variant of Visual Arrestin) Descriptor: S-arrestin Authors: Batra-Safferling, R, Granzin, J. Deposit date: 2011-11-03 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal Structure of p44, a Constitutively Active Splice Variant of Visual Arrestin. J.Mol.Biol., 416, 2012
4OV2	Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus Descriptor: CALCIUM ION, Neuronal calcium sensor 1 Authors: Pandaleneni, S, Burgoyne, R, Mayans, O, Lian, L.-Y. Deposit date: 2014-02-19 Release date: 2014-03-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus To be Published

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