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8Q7N
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BU of 8q7n by Molmil
cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
Deposit date:2023-08-16
Release date:2024-01-24
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
2IO2
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BU of 2io2 by Molmil
Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1
Descriptor: Ran GTPase-activating protein 1, Sentrin-specific protease 2, Small ubiquitin-related modifier 1
Authors:Reverter, D, Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
7F60
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BU of 7f60 by Molmil
Crystal structure of auxiliary protein in complex with human nuclear protein
Descriptor: Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor
Authors:Gao, X, Cui, S.
Deposit date:2021-06-23
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport
Nat Commun, 13, 2022
7F90
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BU of 7f90 by Molmil
Crystal structure of SARS auxiliary protein in complex with human nuclear protein
Descriptor: Nuclear pore complex protein Nup98-Nup96, ORF6 protein, mRNA export factor
Authors:Gao, X, Cui, S.
Deposit date:2021-07-03
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural basis for Sarbecovirus ORF6 mediated blockage of nucleocytoplasmic transport
Nat Commun, 13, 2022
7FBV
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BU of 7fbv by Molmil
The solution structure of the second RRM domain of Matrin-3
Descriptor: Matrin-3
Authors:Muto, Y, Kobayashi, N, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2021-07-13
Release date:2022-02-16
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:1 H, 13 C and 15 N resonance assignments and solution structures of the two RRM domains of Matrin-3.
Biomol.Nmr Assign., 16, 2022
2J0U
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BU of 2j0u by Molmil
The crystal structure of eIF4AIII-Barentsz complex at 3.0 A resolution
Descriptor: ATP-DEPENDENT RNA HELICASE DDX48, PROTEIN CASC3
Authors:Bono, F, Ebert, J, Lorentzen, E, Conti, E.
Deposit date:2006-08-04
Release date:2006-09-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Crystal Structure of the Exon Junction Complex Reveals How It Mantains a Stable Grip on Mrna
Cell(Cambridge,Mass.), 126, 2006
7R5K
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BU of 7r5k by Molmil
Human nuclear pore complex (constricted)
Descriptor: Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ...
Authors:Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M.
Deposit date:2022-02-10
Release date:2022-06-22
Last modified:2022-06-29
Method:ELECTRON MICROSCOPY (12 Å)
Cite:AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Science, 376, 2022
7R5J
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BU of 7r5j by Molmil
Human nuclear pore complex (dilated)
Descriptor: Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ...
Authors:Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M.
Deposit date:2022-02-10
Release date:2022-09-21
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (50 Å)
Cite:AI-based structure prediction empowers integrative structural analysis of human nuclear pores
Science, 376, 2022
8QZS
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BU of 8qzs by Molmil
Cryo-EM structure of the cross-exon B-like complex
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ...
Authors:Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
Deposit date:2023-10-29
Release date:2024-05-22
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8Y0W
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BU of 8y0w by Molmil
dormant ribosome with eIF5A, eEF2 and SERBP1
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Du, M, Zeng, F.
Deposit date:2024-01-23
Release date:2024-02-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:dormant ribosome with eIF5A, eEF2 and SERBP1
To Be Published
6J50
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BU of 6j50 by Molmil
RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome (tilted conformation)
Descriptor: DNA (198-MER), DNA (41-MER), DNA-directed RNA polymerase subunit, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6J4W
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BU of 6j4w by Molmil
RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-5) of the nucleosome
Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6JFB
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BU of 6jfb by Molmil
Crystal structure of human pyruvate kinase M2 isoform
Descriptor: PHOSPHATE ION, Pyruvate kinase PKM Isoform M2, SERINE
Authors:Chen, T.J, Wang, W.C.
Deposit date:2019-02-08
Release date:2020-04-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal structure of human pyruvate kinase M2 isoform
To Be Published
6J4Z
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BU of 6j4z by Molmil
RNA polymerase II elongation complex bound with Spt4/5 and foreign DNA, stalled at SHL(-1) of the nucleosome
Descriptor: DNA (198-MER), DNA (42-MER), DNA-directed RNA polymerase subunit, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6J4X
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BU of 6j4x by Molmil
RNA polymerase II elongation complex bound with Elf1 and Spt4/5, stalled at SHL(-1) of the nucleosome (+1A)
Descriptor: DNA (198-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ...
Authors:Ehara, H, Kujirai, T, Fujino, Y, Shirouzu, M, Kurumizaka, H, Sekine, S.
Deposit date:2019-01-10
Release date:2019-02-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.
Science, 363, 2019
6JOU
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BU of 6jou by Molmil
Crystal structure of the human nucleosome containing H2A.Z.1 S42R
Descriptor: DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ...
Authors:Horikoshi, N, Sato, K, Mizukami, Y, Kurumizaka, H.
Deposit date:2019-03-23
Release date:2020-03-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo.
Biochem.Biophys.Res.Commun., 515, 2019
6H3A
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BU of 6h3a by Molmil
Crystal structure of the KAP1 RBCC domain in complex with the SMARCAD1 CUE1 domain.
Descriptor: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, Transcription intermediary factor 1-beta, ZINC ION
Authors:Newman, J.A, Aitkenhead, H, Lim, M, Williams, H.L, Svejstrup, J.Q, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-07-17
Release date:2019-06-26
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (5.505 Å)
Cite:A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Structure, 27, 2019
6FF4
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BU of 6ff4 by Molmil
human Bact spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
Deposit date:2018-01-03
Release date:2018-08-29
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
6J4I
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BU of 6j4i by Molmil
A conserved and buried edge-to-face aromatic interaction in SUMO is vital for the SUMO pathway
Descriptor: Small ubiquitin-related modifier 1
Authors:Chatterjee, K.S, Das, R.
Deposit date:2019-01-09
Release date:2019-03-13
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A conserved and buried edge-to-face aromatic interaction in small ubiquitin-like modifier (SUMO) has a role in SUMO stability and function.
J.Biol.Chem., 294, 2019
6JXV
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BU of 6jxv by Molmil
SUMO1 bound to phosphorylated SLS4-SIM peptide from ICP0
Descriptor: Phosphorylated SLS4-SIM from ubiquitin E3 ligase ICP0, Small ubiquitin-related modifier
Authors:Hembram, D.S.S, Negi, H, Shet, D, Das, R.
Deposit date:2019-04-25
Release date:2020-02-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2.
J.Mol.Biol., 432, 2020
6JXU
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BU of 6jxu by Molmil
SUMO1 bound to SLS4-SIM peptide from ICP0
Descriptor: Small ubiquitin-related modifier, viral protein
Authors:Hembram, D.S.S, Negi, H, Shet, D, Das, R.
Deposit date:2019-04-25
Release date:2020-02-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2.
J.Mol.Biol., 432, 2020
2N1V
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BU of 2n1v by Molmil
Solution structure of human SUMO1
Descriptor: Small ubiquitin-related modifier 1
Authors:Naik, M.T, Naik, N, Shih, H, Huang, T.
Deposit date:2015-04-24
Release date:2016-04-20
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of human SUMO
To Be Published
2N1A
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BU of 2n1a by Molmil
Docked structure between SUMO1 and ZZ-domain from CBP
Descriptor: CREB-binding protein, Small ubiquitin-related modifier 1, ZINC ION
Authors:Diehl, C.
Deposit date:2015-03-26
Release date:2016-05-04
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.
J.Biol.Chem., 291, 2016
2MW5
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BU of 2mw5 by Molmil
Backbone fold of Human Small Ubiquitin like Modifier protein-1 (SUMO-1) based on Prot3D-NMR approach.
Descriptor: Small ubiquitin-related modifier 1
Authors:Kumar, D, Jaiswal, N, Raikwal, N, Shukla, V, Arora, A.
Deposit date:2014-10-28
Release date:2014-12-03
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Prot3DNMR: A simple and swift NMR strategy for Three-Dimentional structutral determination of proteins.
To be Published
2KQS
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BU of 2kqs by Molmil
Phosphorylation of SUMO-interacting motif by CK2 enhances Daxx SUMO binding activity
Descriptor: Death domain-associated protein 6, Small ubiquitin-related modifier 1
Authors:Naik, M.T, Huang, T.H, Shih, H.
Deposit date:2009-11-17
Release date:2010-12-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.
Mol.Cell, 42, 2011

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