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7SYT
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BU of 7syt by Molmil
Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt)
Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ...
Authors:Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J.
Deposit date:2021-11-25
Release date:2022-07-13
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Embo J., 41, 2022
7SYG
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BU of 7syg by Molmil
Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII)
Descriptor: 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S24, ...
Authors:Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J.
Deposit date:2021-11-25
Release date:2022-07-13
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA
To Be Published
7SU3
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BU of 7su3 by Molmil
CryoEM structure of DNA-PK complex VII
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ...
Authors:Chen, X, Liu, L, Gellert, M, Yang, W.
Deposit date:2021-11-16
Release date:2022-01-12
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Autophosphorylation transforms DNA-PK from protecting to processing DNA ends.
Mol.Cell, 82, 2022
4F6N
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BU of 4f6n by Molmil
Crystal structure of Kaiso zinc finger DNA binding protein in complex with methylated CpG site DNA
Descriptor: DNA (5'-D(*CP*GP*TP*AP*TP*AP*GP*AP*(5CM)P*GP*(5CM)P*GP*GP*TP*GP*AP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*TP*CP*AP*CP*(5CM)P*GP*(5CM)P*GP*TP*CP*TP*AP*TP*AP*CP*G)-3'), GLYCEROL, ...
Authors:Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E.
Deposit date:2012-05-15
Release date:2012-09-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F6M
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BU of 4f6m by Molmil
Crystal structure of Kaiso zinc finger DNA binding domain in complex with Kaiso binding site DNA
Descriptor: DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), Transcriptional regulator Kaiso, ...
Authors:Buck-Koehntop, B.A, Stanfield, R.L, Ekiert, D.C, Martinez-Yamout, M.A, Dyson, H.J, Wilson, I.A, Wright, P.E.
Deposit date:2012-05-15
Release date:2012-09-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for recognition of methylated and specific DNA sequences by the zinc finger protein Kaiso.
Proc.Natl.Acad.Sci.USA, 109, 2012
4F3L
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BU of 4f3l by Molmil
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
Descriptor: BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
7D58
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BU of 7d58 by Molmil
cryo-EM structure of human RNA polymerase III in elongating state
Descriptor: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ...
Authors:Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2020-09-25
Release date:2021-02-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
7D59
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BU of 7d59 by Molmil
cryo-EM structure of human RNA polymerase III in apo state
Descriptor: DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ...
Authors:Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M.
Deposit date:2020-09-25
Release date:2021-02-17
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
8Y6O
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BU of 8y6o by Molmil
Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Centrosomal AT-AC splicing factor, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Bai, R, Yuan, M, Zhang, P, Luo, T, Shi, Y, Wan, R.
Deposit date:2024-02-02
Release date:2024-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome.
Science, 383, 2024
6SWA
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BU of 6swa by Molmil
Mus musculus brain neocortex ribosome 60S bound to Ebp1
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kraushar, M.L, Sprink, T.
Deposit date:2019-09-20
Release date:2020-09-30
Last modified:2021-02-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit.
Mol.Cell, 81, 2021
1PGZ
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BU of 1pgz by Molmil
Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)
Descriptor: 5'-D(*T*TP*AP*GP*GP*GP*TP*TP*AP*GP*(6MI)P*G)-3', Heterogeneous nuclear ribonucleoprotein A1
Authors:Myers, J.C, Moore, S.A, Shamoo, Y.
Deposit date:2003-05-28
Release date:2003-11-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-based incorporation of 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine into the human telomeric repeat DNA as a probe for UP1 binding and destabilization of G-tetrad structures
J.Biol.Chem., 278, 2003
6FF4
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BU of 6ff4 by Molmil
human Bact spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
Authors:Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H.
Deposit date:2018-01-03
Release date:2018-08-29
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
Cell, 172, 2018
6H3A
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BU of 6h3a by Molmil
Crystal structure of the KAP1 RBCC domain in complex with the SMARCAD1 CUE1 domain.
Descriptor: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, Transcription intermediary factor 1-beta, ZINC ION
Authors:Newman, J.A, Aitkenhead, H, Lim, M, Williams, H.L, Svejstrup, J.Q, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O.
Deposit date:2018-07-17
Release date:2019-06-26
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (5.505 Å)
Cite:A Ubiquitin-Binding Domain that Binds a Structural Fold Distinct from that of Ubiquitin.
Structure, 27, 2019
2VRR
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BU of 2vrr by Molmil
Structure of SUMO modified Ubc9
Descriptor: FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ...
Authors:Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A.
Deposit date:2008-04-13
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Ubc9 sumoylation regulates SUMO target discrimination.
Mol. Cell, 31, 2008
7OBB
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BU of 7obb by Molmil
Cryo-EM structure of human RNA Polymerase I Open Complex
Descriptor: DNA non-template strand, DNA template strand, DNA-directed RNA polymerase I subunit RPA1, ...
Authors:Misiaszek, A.D, Girbig, M, Mueller, C.W.
Deposit date:2021-04-21
Release date:2021-12-08
Last modified:2021-12-22
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of human RNA polymerase I.
Nat.Struct.Mol.Biol., 28, 2021
7OB9
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BU of 7ob9 by Molmil
Cryo-EM structure of human RNA Polymerase I in elongation state
Descriptor: DNA non-template strand, DNA template strand, DNA-directed RNA polymerase I subunit RPA1, ...
Authors:Misiaszek, A.D, Girbig, M, Mueller, C.W.
Deposit date:2021-04-21
Release date:2021-12-08
Last modified:2021-12-22
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures of human RNA polymerase I.
Nat.Struct.Mol.Biol., 28, 2021
7OBA
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BU of 7oba by Molmil
Cryo-EM structure of human RNA Polymerase I in complex with RRN3
Descriptor: DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA2, ...
Authors:Misiaszek, A.D, Girbig, M, Mueller, C.W.
Deposit date:2021-04-21
Release date:2021-12-08
Last modified:2021-12-22
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cryo-EM structures of human RNA polymerase I.
Nat.Struct.Mol.Biol., 28, 2021
5XF3
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BU of 5xf3 by Molmil
Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,R-configuration)
Descriptor: (1R,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ...
Authors:Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
7NVM
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BU of 7nvm by Molmil
Human TRiC complex in closed state with nanobody Nb18, actin and PhLP2A bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Actin, ...
Authors:Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W, Structural Genomics Consortium (SGC)
Deposit date:2021-03-15
Release date:2022-03-02
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
7NVO
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BU of 7nvo by Molmil
Human TRiC complex in open state with nanobody bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
Authors:Kelly, J.J, Chi, G, Bulawa, C, Paavilainen, V.O, Bountra, C, Huiskonen, J.T, Yue, W.
Deposit date:2021-03-15
Release date:2022-03-02
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat.Struct.Mol.Biol., 29, 2022
3KLT
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BU of 3klt by Molmil
Crystal structure of a vimentin fragment
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CALCIUM ION, HEXAETHYLENE GLYCOL, ...
Authors:Nicolet, S, Strelkov, S.V.
Deposit date:2009-11-09
Release date:2010-05-26
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Atomic structure of vimentin coil 2.
J.Struct.Biol., 170, 2010
5XF5
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BU of 5xf5 by Molmil
Nucleosome core particle with an adduct of a binuclear RAPTA (Ru-arene-phosphaadamantane) compound having a 1,2-diphenylethylenediamine linker (R,S-configuration)
Descriptor: (1S,2R)-1,2-diphenylethane-1,2-diamine, DNA (145-MER), Histone H2A type 1-B/E, ...
Authors:Ma, Z, Adhireksan, Z, Murray, B.S, Dyson, P.J, Davey, C.A.
Deposit date:2017-04-07
Release date:2017-10-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Nat Commun, 8, 2017
2ASQ
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BU of 2asq by Molmil
Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM)
Descriptor: Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1
Authors:Song, J, Zhang, Z, Hu, W, Chen, Y.
Deposit date:2005-08-23
Release date:2005-10-11
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif: A reversal of the bound orientation
J.Biol.Chem., 280, 2005
3U5M
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BU of 3u5m by Molmil
Crystal structure of TRIM33 PHD-Bromo in the free state
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase TRIM33, ZINC ION
Authors:Wang, Z, Patel, D.J.
Deposit date:2011-10-11
Release date:2012-01-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:A poised chromatin platform for TGF-beta access to master regulators
Cell(Cambridge,Mass.), 147, 2011
6DCL
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BU of 6dcl by Molmil
Crystal structure of UP1 bound to pri-miRNA-18a terminal loop
Descriptor: 1,2-ETHANEDIOL, Heterogeneous nuclear ribonucleoprotein A1, RNA (5'-R(*AP*GP*UP*AP*GP*AP*UP*UP*AP*GP*C)-3')
Authors:Kooshapur, H, Sattler, M.
Deposit date:2018-05-07
Release date:2018-06-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
Nat Commun, 9, 2018

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