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9CPA	Structure of a Mammalian DHX29-bound 43S Pre-initiation Complex Descriptor: 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... Authors: Cui, D, des Georges, A. Deposit date: 2024-07-18 Release date: 2025-07-23 Last modified: 2025-08-27 Method: ELECTRON MICROSCOPY (6 Å) Cite: The translation initiation factor DHX29 appears to pull on mRNA in a direction opposite to scanning. Biorxiv, 2025
7SYJ	Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 4(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYW	Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt) Descriptor: 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYL	Structure of the HCV IRES bound to the 40S ribosomal subunit, closed conformation. Structure 6(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYQ	Structure of the wt IRES and 40S ribosome ternary complex, open conformation. Structure 11(wt) Descriptor: 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYP	Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt) Descriptor: 18S rRNA, HCV IRES, HCV IRES partially loaded mRNA portion, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (4 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYR	Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt). Descriptor: 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYS	Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII). Descriptor: 18S rRNA, Eukaryotic translation initiation factor 1A, X-chromosomal, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
8UIK	In situ HHT and CHX treated human 80S ribosome with EBP1 (consensus map) Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA, 28S rRNA, ... Authors: Wei, Z, Yong, X. Deposit date: 2023-10-10 Release date: 2025-04-30 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: In situ HHT and CHX treated human 80S ribosome with EBP1 (consensus map) To Be Published
7SYK	Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 5(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYI	Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYU	Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYT	Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt) Descriptor: 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYV	Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt) Descriptor: 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-20 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYO	Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S2, HCV IRES, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-27 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
7SYX	Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII) Descriptor: 18S rRNA, 40S ribosomal protein S24, 40S ribosomal protein S25, ... Authors: Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. Deposit date: 2021-11-25 Release date: 2022-07-13 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
6SWA	Mus musculus brain neocortex ribosome 60S bound to Ebp1 Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Kraushar, M.L, Sprink, T. Deposit date: 2019-09-20 Release date: 2020-09-30 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Protein Synthesis in the Developing Neocortex at Near-Atomic Resolution Reveals Ebp1-Mediated Neuronal Proteostasis at the 60S Tunnel Exit. Mol.Cell, 81, 2021
8SUP	Structure of the 48S translation initiation complex assembled on the encephalomyocarditis virus IRES Descriptor: 18S rRNA, 40S ribosomal protein S2, EMCV mRNA, ... Authors: Bhattacharjee, S, Abaeva, I.S, Brown, Z.P, Arhab, Y, Fallah, H, Jeevan, J.C, Hellen, C.U.T, Frank, J, Pestova, T.V. Deposit date: 2023-05-12 Release date: 2026-03-18 Last modified: 2026-04-01 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The mechanism of ribosomal recruitment during translation initiation on the Type 2 encephalomyocarditis virus IRES. Embo J., 2026
22TU	Human 80S ribosome in complex with DHX29 Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... Authors: Goto-Ito, S, Iwasaki, W, Ito, T. Deposit date: 2026-01-22 Release date: 2026-04-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: Human DHX29 detects nonoptimal codon usage to regulate mRNA stability. Science, 2026
3J7O	Structure of the mammalian 60S ribosomal subunit Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. Deposit date: 2014-08-01 Release date: 2014-09-03 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution. Cell(Cambridge,Mass.), 157, 2014
7QVP	Human collided disome (di-ribosome) stalled on XBP1 mRNA Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... Authors: Denk, T.G, Tesina, P, Beckmann, R. Deposit date: 2022-01-22 Release date: 2022-10-12 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3 Å) Cite: A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation. Nat Commun, 13, 2022
8P09	48S late-stage initiation complex with non methylated mRNA Descriptor: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... Authors: Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. Deposit date: 2023-05-09 Release date: 2024-03-20 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
8P03	48S late-stage initiation complex with m6A mRNA Descriptor: 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... Authors: Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. Deposit date: 2023-05-09 Release date: 2024-03-20 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.04 Å) Cite: N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
8UKB	In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA, 28S rRNA, ... Authors: Wei, Z, Yong, X. Deposit date: 2023-10-12 Release date: 2024-11-20 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: In situ human hibernating rotated state 80S ribosome To Be Published
9H6Y	Late-stage 48S Initiation Complex (LS48S IC) guided by the trans-RNA Descriptor: 18S ribosomal RNA, 40S ribosomal protein S24, ATP binding cassette subfamily E member 1, ... Authors: Nguyen, T.T, Hashem, Y, Rocha, R.E.O, Boissier, F, Qian, S.B, Jia, L, Uematsu, S, Gu, Y, Shi, S. Deposit date: 2024-10-25 Release date: 2025-12-10 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Programmable initiation of mRNA translation by trans-RNA. Nat.Biotechnol., 2025

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