PDB: 79225 resultsInfo pagesStatus searchChemie searchBIRD

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3KJZ	Crystal structure of native peptidyl-tRNA hydrolase from Mycobacterium smegmatis Descriptor: Peptidyl-tRNA hydrolase Authors: Kumar, A, Singh, N, Yadav, R, Prem Kumar, R, Sharma, S, Arora, A, Singh, T.P. Deposit date: 2009-11-04 Release date: 2010-08-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase from mycobacterium smegmatis reveals novel features related to enzyme dynamics. Int J Biochem Mol Biol, 3, 2012
1E24	LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and ATP and MN2+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, LYSINE, ... Authors: Desogus, G, Todone, F, Brick, P, Onesti, S. Deposit date: 2000-05-16 Release date: 2000-07-28 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
1E22	LYSYL-TRNA SYNTHETASE (LYSU) HEXAGONAL FORM complexed with lysine and the non-hydrolysable atp analogue amp-pcp Descriptor: GLYCEROL, LYSINE, LYSYL-TRNA SYNTHETASE, ... Authors: Desogus, G, Todone, F, Brick, P, Onesti, S. Deposit date: 2000-05-15 Release date: 2000-07-28 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Active Site of Lysyl-tRNA Synthetase: Structural Studies of the Adenylation Reaction Biochemistry, 39, 2000
4JY7	Crystal structure of Acinetobacter baumannii Peptidyl-tRNA Hydrolase Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Yamini, S, Kaushik, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2013-03-29 Release date: 2013-04-17 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii Plos One, 8, 2013
4JWK	Crystal structure of the complex of peptidyl-tRNA hydrolase from Acinetobacter baumannii with cytidine at 1.87 A resolution Descriptor: 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, Peptidyl-tRNA hydrolase Authors: Kaushik, S, Singh, N, Yamini, S, Singh, A, Sinha, M, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2013-03-27 Release date: 2013-06-05 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.87 Å) Cite: The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii Plos One, 8, 2013
4Q2Y	Crystal structure of Arginyl-tRNA synthetase Descriptor: Arginine--tRNA ligase, cytoplasmic Authors: Kim, H.S, Jo, C.H, Cha, S.Y, Han, A.R, Hwang, K.Y. Deposit date: 2014-04-10 Release date: 2014-07-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.799 Å) Cite: The crystal structure of arginyl-tRNA synthetase from Homo sapiens Febs Lett., 588, 2014
4Q2X	Crystal structure of Arginyl-tRNA synthetase complexed with L-canavanine Descriptor: Arginine--tRNA ligase, cytoplasmic, L-CANAVANINE Authors: Kim, H.S, Jo, C.H, Cha, S.Y, Han, A.R, Hwang, K.Y. Deposit date: 2014-04-10 Release date: 2014-07-23 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.798 Å) Cite: The crystal structure of arginyl-tRNA synthetase from Homo sapiens Febs Lett., 588, 2014
3HV0	Tryptophanyl-tRNA synthetase from Cryptosporidium parvum Descriptor: TRYPTOPHAN, Tryptophanyl-tRNA synthetase Authors: Arakaki, T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2009-06-15 Release date: 2009-06-30 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol.Biochem.Parasitol., 177, 2011
1IQ0	THERMUS THERMOPHILUS ARGINYL-TRNA SYNTHETASE Descriptor: ARGINYL-TRNA SYNTHETASE Authors: Shimada, A, Nureki, O, Goto, M, Takahashi, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2001-05-24 Release date: 2001-11-28 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase. Proc.Natl.Acad.Sci.USA, 98, 2001
3HRI	Histidyl-tRNA synthetase (apo) from Trypanosoma brucei Descriptor: Histidyl-tRNA synthetase Authors: Arakaki, T.L, Merritt, E.A, Larson, E.T, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Deposit date: 2009-06-09 Release date: 2009-12-01 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J.Mol.Biol., 397, 2010
4QT4	Crystal structure of Peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 Angstrom resolution shows the Closed Structure of the Substrate Binding Cleft Descriptor: Peptidyl-tRNA hydrolase Authors: Singh, A, Gautam, L, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Singh, T.P. Deposit date: 2014-07-07 Release date: 2014-08-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Crystal structure of peptidyl-tRNA hydrolase from a Gram-positive bacterium, Streptococcus pyogenes at 2.19 angstrom resolution shows the closed structure of the substrate-binding cleft. FEBS Open Bio, 4, 2014
3AFH	Crystal structure of Thermotoga maritima nondiscriminating glutamyl-tRNA synthetase in complex with a glutamyl-AMP analog Descriptor: Glutamyl-tRNA synthetase 2, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE Authors: Ito, T, Yokoyama, S. Deposit date: 2010-03-01 Release date: 2010-06-30 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of nondiscriminating glutamyl-tRNA synthetase from Thermotoga maritima Acta Crystallogr.,Sect.D, 66, 2010
1JZQ	Isoleucyl-tRNA synthetase Complexed with Isoleucyl-adenylate analogue Descriptor: Isoleucyl-tRNA synthetase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ZINC ION Authors: Nakama, T, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2001-09-17 Release date: 2001-12-21 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J.Biol.Chem., 276, 2001
1JZS	Isoleucyl-tRNA synthetase Complexed with mupirocin Descriptor: Isoleucyl-tRNA synthetase, MUPIROCIN, ZINC ION Authors: Nakama, T, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2001-09-17 Release date: 2001-12-21 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J.Biol.Chem., 276, 2001
1BBU	LYSYL-TRNA SYNTHETASE (LYSS) COMPLEXED WITH LYSINE Descriptor: LYSINE, PROTEIN (LYSYL-TRNA SYNTHETASE) Authors: Onesti, S, Desogus, G, Brevet, A, Chen, J, Plateau, P, Blanquet, S, Brick, P. Deposit date: 1998-04-24 Release date: 2000-11-10 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding. Biochemistry, 39, 2000
1BBW	LYSYL-TRNA SYNTHETASE (LYSS) Descriptor: PROTEIN (LYSYL-TRNA SYNTHETASE) Authors: Onesti, S, Desogus, G, Brevet, A, Chen, J, Plateau, P, Blanquet, S, Brick, P. Deposit date: 1998-04-24 Release date: 2000-11-10 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural studies of lysyl-tRNA synthetase: conformational changes induced by substrate binding. Biochemistry, 39, 2000
1RQG	Methionyl-tRNA synthetase from Pyrococcus abyssi Descriptor: Methionyl-tRNA synthetase, ZINC ION Authors: Crepin, T, Schmitt, E, Blanquet, S, Mechulam, Y. Deposit date: 2003-12-05 Release date: 2004-05-25 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Three-dimensional structure of methionyl-tRNA synthetase from Pyrococcus abyssi. Biochemistry, 43, 2004
5HGQ	Loa loa Lysyl-tRNA synthetase in complex with Cladosporin. Descriptor: GLYCEROL, LYSINE, Lysine--tRNA ligase, ... Authors: Sharma, A, Sharma, M, Yogavel, M, Sharma, A. Deposit date: 2016-01-08 Release date: 2016-10-26 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.283 Å) Cite: Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis PLoS Negl Trop Dis, 10, 2016
6HCV	Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum complexed with a chromone ligand Descriptor: 6-fluoranyl-~{N}-[(1-oxidanylcyclohexyl)methyl]-4-oxidanylidene-chromene-2-carboxamide, Lysine--tRNA ligase Authors: Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H. Deposit date: 2018-08-16 Release date: 2019-04-03 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc.Natl.Acad.Sci.USA, 116, 2019
6DCL	Crystal structure of UP1 bound to pri-miRNA-18a terminal loop Descriptor: 1,2-ETHANEDIOL, Heterogeneous nuclear ribonucleoprotein A1, RNA (5'-R(*AP*GP*UP*AP*GP*AP*UP*UP*AP*GP*C)-3') Authors: Kooshapur, H, Sattler, M. Deposit date: 2018-05-07 Release date: 2018-06-27 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.497 Å) Cite: Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1. Nat Commun, 9, 2018
6HCU	Crystal Structure of Lysyl-tRNA Synthetase from Plasmodium falciparum bound to a difluoro cyclohexyl chromone ligand Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, HISTIDINE, ... Authors: Tamjar, J, Robinson, D.A, Baragana, B, Norcross, N, Forte, B, Walpole, C, Gilbert, I.H. Deposit date: 2018-08-16 Release date: 2019-04-03 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proc.Natl.Acad.Sci.USA, 116, 2019
7FG6	Crystal structure of the Tyrosyl-tRNA synthetase (TyrRS) in Nanoarchaeum equitans Descriptor: Tyrosine--tRNA ligase Authors: Noguchi, H, Kamata, K, Park, S.Y, Tamura, K. Deposit date: 2021-07-26 Release date: 2021-09-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Crystal structure of Nanoarchaeum equitans tyrosyl-tRNA synthetase and its aminoacylation activity toward tRNA Tyr with an extra guanosine residue at the 5'-terminus. Biochem.Biophys.Res.Commun., 575, 2021
2XGT	Asparaginyl-tRNA synthetase from Brugia malayi complexed with the sulphamoyl analogue of asparaginyl-adenylate Descriptor: 5'-O-[N-(L-ASPARAGINYL)SULFAMOYL]ADENOSINE, ASPARAGINYL-TRNA SYNTHETASE, CYTOPLASMIC, ... Authors: Crepin, T, Haertlein, M, Kron, M, Cusack, S. Deposit date: 2010-06-07 Release date: 2010-12-15 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: A Hybrid Structural Model of the Complete Brugia Malayi Cytoplasmic Asparaginyl-tRNA Synthetase. J.Mol.Biol., 405, 2011
2XTI	Asparaginyl-tRNA synthetase from Brugia malayi complexed with ATP:Mg and L-Asp-beta-NOH adenylate:PPi:Mg Descriptor: 5'-O-[(R)-{[(2S)-2-amino-4-(hydroxyamino)-4-oxobutanoyl]oxy}(hydroxy)phosphoryl]adenosine, ADENOSINE-5'-TRIPHOSPHATE, ASPARAGINYL-TRNA SYNTHETASE, ... Authors: Crepin, T, Haertlein, M, Kron, M, Cusack, S. Deposit date: 2010-10-10 Release date: 2010-12-15 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A Hybrid Structural Model of the Complete Brugia Malayi Cytoplasmic Asparaginyl-tRNA Synthetase. J.Mol.Biol., 405, 2011
2Z2I	Crystal structure of Peptidyl-tRNA hydrolase from Mycobacterium tuberculosis Descriptor: Peptidyl-tRNA hydrolase Authors: Selvaraj, M, Roy, S, Singh, N.S, Sangeetha, R, Varshney, U, Vijayan, M. Deposit date: 2007-05-22 Release date: 2007-07-24 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Structural Plasticity and Enzyme Action: Crystal Structures of Mycobacterium tuberculosis Peptidyl-tRNA Hydrolase J.Mol.Biol., 372, 2007

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