9M2Q
 
 | | Imidazole glycerol phosphate dehydratase from Mycobacterium tuberculosis, in complex with aminotriazole | | Descriptor: | 3-AMINO-1,2,4-TRIAZOLE, Imidazoleglycerol-phosphate dehydratase, MANGANESE (II) ION | | Authors: | Raina, R, Kar, D, Singla, M, Tiwari, S, Kumari, S, Aneja, S, Kumar, V, Banerjee, S, Goyal, S, Pal, R.K, Vinothkumar, K.R, Biswal, B.K. | | Deposit date: | 2025-02-28 | | Release date: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of Mycobacterium tuberculosis imidazole glycerol phosphate dehydratase in the apo state and in the presence of small molecules.
Acta Crystallogr.,Sect.F, 2025
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8BR4
 | | Structure of GAPDH from Mycobacterium tuberculosis | | Descriptor: | 1,2-ETHANEDIOL, Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Kumar, A, Karthikeyan, S. | | Deposit date: | 2022-11-22 | | Release date: | 2023-11-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.29 Å) | | Cite: | Stoichiometry of ligand binding and role of C-terminal lysines in Mycobacterium tuberculosis and human GAPDH multifunctionality.
Febs J., 2024
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2A4W
 | | Crystal Structure Of Mitomycin C-Binding Protein Complexed with Copper(II)-Bleomycin A2 | | Descriptor: | BLEOMYCIN A2, COPPER (II) ION, Mitomycin-Binding Protein | | Authors: | Danshiitsoodol, N, de Pinho, C.A, Matoba, Y, Kumagai, T, Sugiyama, M. | | Deposit date: | 2005-06-30 | | Release date: | 2006-07-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin: Crystallographic Analysis to Elucidate the Binding Mode of the Antibiotic to the Protein
J.Mol.Biol., 360, 2006
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2A4X
 | | Crystal Structure Of Mitomycin C-Binding Protein Complexed with Metal-Free Bleomycin A2 | | Descriptor: | BLEOMYCIN A2, Mitomycin-Binding Protein | | Authors: | Danshiitsoodol, N, de Pinho, C.A, Matoba, Y, Kumagai, T, Sugiyama, M. | | Deposit date: | 2005-06-30 | | Release date: | 2006-07-18 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin: Crystallographic Analysis to Elucidate the Binding Mode of the Antibiotic to the Protein
J.Mol.Biol., 360, 2006
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1N5J
 | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE DIPHOSPHATE (TDP) AND THYMIDINE TRIPHOSPHATE (TTP) AT PH 5.4 (1.85 A RESOLUTION) | | Descriptor: | MAGNESIUM ION, SULFATE ION, THYMIDINE-5'-DIPHOSPHATE, ... | | Authors: | Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D. | | Deposit date: | 2002-11-06 | | Release date: | 2003-04-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the
Reaction Pathway
J.Mol.Biol., 327, 2003
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1N5I
 | | CRYSTAL STRUCTURE OF INACTIVE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP) AT PH 4.6 (RESOLUTION 1.85 A) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CITRATE ANION, SULFATE ION, ... | | Authors: | Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D. | | Deposit date: | 2002-11-06 | | Release date: | 2003-04-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the Reaction Pathway
J.Mol.Biol., 327, 2003
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1N5K
 | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE (RESOLUTION 2.1 A) | | Descriptor: | ACETATE ION, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ... | | Authors: | Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D. | | Deposit date: | 2002-11-06 | | Release date: | 2003-04-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the
Reaction Pathway
J.Mol.Biol., 375, 2003
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1N5L
 | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE CRYSTALLIZED IN SODIUM MALONATE, AFTER CATALYSIS IN THE CRYSTAL (2.3 A RESOLUTION) | | Descriptor: | ACETATE ION, DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Fioravanti, E, Haouz, A, Ursby, T, Munier-Lehmann, H, Delarue, M, Bourgeois, D. | | Deposit date: | 2002-11-06 | | Release date: | 2003-04-15 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mycobacterium tuberculosis Thymidylate Kinase: Structural Studies of Intermediates along the
Reaction Pathway
J.Mol.Biol., 375, 2003
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7CLL
 | | Mycobacterium tubeculosis enolase in complex with 2-Phosphoglycerate | | Descriptor: | 2-PHOSPHOGLYCERIC ACID, ACETATE ION, CHLORIDE ION, ... | | Authors: | Ahmad, M, Jha, B, Tiwari, S, Pal, R.K, Biswal, B.K. | | Deposit date: | 2020-07-21 | | Release date: | 2021-07-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis.
Iucrj, 10, 2023
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7DLR
 | | Mycobacterium tuberculosis enolase mutant - E163A | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | Authors: | Ahmad, M, Biswal, B.K. | | Deposit date: | 2020-11-30 | | Release date: | 2021-12-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis.
Iucrj, 10, 2023
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7CLK
 | | Mycobacterium tuberculosis enolase in complex with alternate 2-phosphoglycerate | | Descriptor: | 1,2-ETHANEDIOL, 2-PHOSPHOGLYCERIC ACID, ACETATE ION, ... | | Authors: | Ahmad, M, Jha, B, Tiwari, S, Pal, R.K, Biswal, B.K. | | Deposit date: | 2020-07-21 | | Release date: | 2022-01-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural snapshots of Mycobacterium tuberculosis enolase reveal dual mode of 2PG binding and its implication in enzyme catalysis.
Iucrj, 10, 2023
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6KHH
 | | Crystal Structure of HisB from Mycobacterium tuberculosis | | Descriptor: | ACETAMIDE, CHLORIDE ION, Imidazoleglycerol-phosphate dehydratase, ... | | Authors: | Kumar, D, Jha, B, Pal, R.K, Biswal, B.K. | | Deposit date: | 2019-07-15 | | Release date: | 2020-07-15 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase.
Proteins, 2021
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7FE6
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8Q3I
 | | Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-14 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8R3M
 | | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal, CO and PCh loop domain, and an upstream-fork promoter fragment; State III conformation | | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-11-09 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8QN8
 | | Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State II | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-09-25 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8R2M
 | | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and an upstream-fork promoter fragment; State III conformation | | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-11-06 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8QU6
 | | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD and an upstream-fork promoter fragment | | Descriptor: | DNA 22-MER, DNA 31-MER, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-10-13 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8R6P
 | | Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA, HelD N-terminal domain and open promoter DNA | | Descriptor: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-11-22 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8QTI
 | | Mycobacterium smegnatis RNAP open promoter complex with SigmaA and RbpA | | Descriptor: | DNA 50-mer non-template strand, DNA 50-mer template strand, DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-10-12 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8R6R
 | | Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA and open promoter DNA | | Descriptor: | DNA 50-MER, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Koval, T, Krasny, L, Dohnalek, J, Kouba, T. | | Deposit date: | 2023-11-22 | | Release date: | 2024-10-02 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (3.89 Å) | | Cite: | Mycobacterial HelD connects RNA polymerase recycling with transcription initiation.
Nat Commun, 15, 2024
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8PBY
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8PBX
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8RBL
 | | Crystal structure of Mycobacterium tuberculosis MmaA1 with S-adenosyl homocysteine | | Descriptor: | 1,2-ETHANEDIOL, Mycolic acid methyltransferase MmaA1, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Kobakhidze, G, Wachelder, L, Chaudhary, B, Mazumdar, P.A, Madhurantakam, C, Dong, G. | | Deposit date: | 2023-12-04 | | Release date: | 2024-12-11 | | Last modified: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structures of the mycolic acid methyl transferase 1 (MmaA1) from Mycobacterium tuberculosis in the apo-form and in complex with different cofactors reveal unique features for substrate binding.
J.Biomol.Struct.Dyn., 2025
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8RBE
 | | Crystal structure of Mycobacterium tuberculosis MmaA1 in apo form | | Descriptor: | GLYCEROL, Mycolic acid methyltransferase MmaA1 | | Authors: | Kobakhidze, G, Wachelder, L, Chaudhary, B, Mazumdar, P.A, Madhurantakam, C, Dong, G. | | Deposit date: | 2023-12-04 | | Release date: | 2024-12-11 | | Last modified: | 2025-06-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of the mycolic acid methyl transferase 1 (MmaA1) from Mycobacterium tuberculosis in the apo-form and in complex with different cofactors reveal unique features for substrate binding.
J.Biomol.Struct.Dyn., 2025
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