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8QSH
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BU of 8qsh by Molmil
Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 23 (1083848).
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, ARAF peptide pS214, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSD
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BU of 8qsd by Molmil
Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 79 (1124379).
Descriptor: 14-3-3 protein sigma, 2-chloranyl-1-[8-(4-iodophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone, BRAF peptide pS365, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSB
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BU of 8qsb by Molmil
Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 86 (1124384).
Descriptor: 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, ARAF peptide pS214, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QS6
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BU of 8qs6 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354)
Descriptor: 14-3-3 protein sigma, C-RAF peptide pS259, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QS5
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BU of 8qs5 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354)
Descriptor: 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[3-fluoranyl-4-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]ethanamide, C-RAF peptide pS259, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSA
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BU of 8qsa by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 86 (1084384)
Descriptor: 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSF
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BU of 8qsf by Molmil
Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 22 (1083853).
Descriptor: 14-3-3 protein sigma, BRAF peptide pS365, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QS8
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BU of 8qs8 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378)
Descriptor: 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QS9
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BU of 8qs9 by Molmil
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 83 (1084383)
Descriptor: 1-[8-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide pS259, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSG
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BU of 8qsg by Molmil
Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 86 (1124384).
Descriptor: 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, BRAF peptide pS365, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8QSC
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BU of 8qsc by Molmil
Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 22 (1083853).
Descriptor: 14-3-3 protein sigma, ARAF peptide pS214, CHLORIDE ION, ...
Authors:Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R.
Deposit date:2023-10-10
Release date:2025-04-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway
To Be Published
8S09
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BU of 8s09 by Molmil
H. sapiens MCM2-7 double hexamer bound to double stranded DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
8S0C
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BU of 8s0c by Molmil
H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex
Descriptor: DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
8S0B
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BU of 8s0b by Molmil
H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
8S0F
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BU of 8s0f by Molmil
H. sapiens OC1M bound to double stranded DNA
Descriptor: DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
8S0E
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BU of 8s0e by Molmil
H. sapiens OCCM bound to double stranded DNA
Descriptor: Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
7QOF
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BU of 7qof by Molmil
Icosahedral capsid of the phicrAss001 virion
Descriptor: Auxiliary capsid protein gp36, Head fiber dimer protein gp29, Head fiber trimer protein gp21, ...
Authors:Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A.
Deposit date:2021-12-24
Release date:2023-03-29
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural atlas of a human gut crassvirus.
Nature, 617, 2023
8S0A
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BU of 8s0a by Molmil
H. sapiens MCM2-7 hexamer bound to double stranded DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ...
Authors:Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A.
Deposit date:2024-02-13
Release date:2024-10-02
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:MCM double hexamer loading visualized with human proteins.
Nature, 636, 2024
7QOH
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BU of 7qoh by Molmil
Unique vertex of the phicrAss001 virion with C5 symmetry imposed
Descriptor: Auxiliary capsid protein gp36, Head fiber trimer protein gp21, MAGNESIUM ION, ...
Authors:Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A.
Deposit date:2021-12-24
Release date:2023-03-29
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structural atlas of a human gut crassvirus.
Nature, 617, 2023
7QOI
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BU of 7qoi by Molmil
Unique vertex of the phicrAss001 virion
Descriptor: Auxiliary capsid protein gp36, Cargo protein 1 gp45, Head fiber trimer protein gp21, ...
Authors:Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A.
Deposit date:2021-12-24
Release date:2023-03-29
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.62 Å)
Cite:Structural atlas of a human gut crassvirus.
Nature, 617, 2023
8S7C
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BU of 8s7c by Molmil
Ternary Complex of Cachd1, FZD5 and LRP6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ...
Authors:Zhao, Y, Ren, J, Jones, E.Y.
Deposit date:2024-02-29
Release date:2024-04-24
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (4.7 Å)
Cite:Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
Science, 384, 2024
6F9Q
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BU of 6f9q by Molmil
Binary complex of a 7S-cis-cis-nepetalactol cyclase from Nepeta mussinii with NAD+
Descriptor: 7S-cis-cis-nepetalactol cyclase, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lichman, B.R, Kamileen, M.O, Titchiner, G, Saalbach, G, Stevenson, C.E.M, Lawson, D.M, O'Connor, S.E.
Deposit date:2017-12-15
Release date:2018-12-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
Nat. Chem. Biol., 15, 2019
4N0U
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BU of 4n0u by Molmil
Ternary complex between Neonatal Fc receptor, serum albumin and Fc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ...
Authors:Oganesyan, V, Wu, H, Dall'Acqua, W.F.
Deposit date:2013-10-02
Release date:2014-02-05
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms.
J.Biol.Chem., 289, 2014
4O3M
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BU of 4o3m by Molmil
Ternary complex of Bloom's syndrome helicase
Descriptor: 1,2-ETHANEDIOL, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*TP*CP*CP*CP*TP*TP*A)-3', ...
Authors:Swan, M.K, Bertrand, J.
Deposit date:2013-12-18
Release date:2014-03-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Acta Crystallogr.,Sect.D, 70, 2014
8PC5
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BU of 8pc5 by Molmil
H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex
Descriptor: Histone H2A, Histone H2B 1.1, Histone H3, ...
Authors:Koutna, E, Kouba, T, Veverka, V.
Deposit date:2023-06-09
Release date:2023-08-16
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Multivalency of nucleosome recognition by LEDGF.
Nucleic Acids Res., 51, 2023

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PDB entries from 2025-07-09

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