8QSH
 
 | Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 23 (1083848). | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-(4-iodophenyl)sulfonylpiperidin-4-yl]methyl]ethanamide, ARAF peptide pS214, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSD
 
 | Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 79 (1124379). | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-1-[8-(4-iodophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]ethanone, BRAF peptide pS365, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSB
 
 | Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 86 (1124384). | Descriptor: | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, ARAF peptide pS214, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QS6
 
 | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354) | Descriptor: | 14-3-3 protein sigma, C-RAF peptide pS259, CHLORIDE ION, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QS5
 
 | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 21 (1075354) | Descriptor: | 14-3-3 protein sigma, 2-chloranyl-~{N}-[[1-[3-fluoranyl-4-(trifluoromethyl)phenyl]sulfonylpiperidin-4-yl]methyl]ethanamide, C-RAF peptide pS259, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSA
 
 | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 86 (1084384) | Descriptor: | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSF
 
 | Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 22 (1083853). | Descriptor: | 14-3-3 protein sigma, BRAF peptide pS365, CHLORIDE ION, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QS8
 
 | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 78 (1084378) | Descriptor: | 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QS9
 
 | Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 83 (1084383) | Descriptor: | 1-[8-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, C-RAF peptide pS259, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSG
 
 | Ternary structure of 14-3-3s, BRAF phosphopeptide (pS365) and compound 86 (1124384). | Descriptor: | 1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, BRAF peptide pS365, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8QSC
 
 | Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 22 (1083853). | Descriptor: | 14-3-3 protein sigma, ARAF peptide pS214, CHLORIDE ION, ... | Authors: | Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. | Deposit date: | 2023-10-10 | Release date: | 2025-04-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Small molecule stabilization of the 14-3-3sigma/CRAF complex inhibits the MAPK pathway To Be Published
|
|
8S09
 
 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
8S0C
 
 | H. sapiens ORC1-5 bound to double stranded DNA as part of the MCM-ORC complex | Descriptor: | DNA (26-mer), Isoform 2 of Origin recognition complex subunit 3, MAGNESIUM ION, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
8S0B
 
 | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
8S0F
 
 | H. sapiens OC1M bound to double stranded DNA | Descriptor: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
8S0E
 
 | H. sapiens OCCM bound to double stranded DNA | Descriptor: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
7QOF
 
 | Icosahedral capsid of the phicrAss001 virion | Descriptor: | Auxiliary capsid protein gp36, Head fiber dimer protein gp29, Head fiber trimer protein gp21, ... | Authors: | Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. | Deposit date: | 2021-12-24 | Release date: | 2023-03-29 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structural atlas of a human gut crassvirus. Nature, 617, 2023
|
|
8S0A
 
 | H. sapiens MCM2-7 hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | MCM double hexamer loading visualized with human proteins. Nature, 636, 2024
|
|
7QOH
 
 | Unique vertex of the phicrAss001 virion with C5 symmetry imposed | Descriptor: | Auxiliary capsid protein gp36, Head fiber trimer protein gp21, MAGNESIUM ION, ... | Authors: | Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. | Deposit date: | 2021-12-24 | Release date: | 2023-03-29 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural atlas of a human gut crassvirus. Nature, 617, 2023
|
|
7QOI
 
 | Unique vertex of the phicrAss001 virion | Descriptor: | Auxiliary capsid protein gp36, Cargo protein 1 gp45, Head fiber trimer protein gp21, ... | Authors: | Bayfield, O.W, Shkoporov, A.N, Yutin, N, Khokhlova, E.V, Smith, J.L.R, Hawkins, D.E.D.P, Koonin, E.V, Hill, C, Antson, A.A. | Deposit date: | 2021-12-24 | Release date: | 2023-03-29 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural atlas of a human gut crassvirus. Nature, 617, 2023
|
|
8S7C
 
 | Ternary Complex of Cachd1, FZD5 and LRP6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ... | Authors: | Zhao, Y, Ren, J, Jones, E.Y. | Deposit date: | 2024-02-29 | Release date: | 2024-04-24 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (4.7 Å) | Cite: | Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science, 384, 2024
|
|
6F9Q
 
 | Binary complex of a 7S-cis-cis-nepetalactol cyclase from Nepeta mussinii with NAD+ | Descriptor: | 7S-cis-cis-nepetalactol cyclase, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Lichman, B.R, Kamileen, M.O, Titchiner, G, Saalbach, G, Stevenson, C.E.M, Lawson, D.M, O'Connor, S.E. | Deposit date: | 2017-12-15 | Release date: | 2018-12-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. Nat. Chem. Biol., 15, 2019
|
|
4N0U
 
 | Ternary complex between Neonatal Fc receptor, serum albumin and Fc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Ig gamma-1 chain C region, ... | Authors: | Oganesyan, V, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2013-10-02 | Release date: | 2014-02-05 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms. J.Biol.Chem., 289, 2014
|
|
4O3M
 
 | Ternary complex of Bloom's syndrome helicase | Descriptor: | 1,2-ETHANEDIOL, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*TP*CP*CP*CP*TP*TP*A)-3', ... | Authors: | Swan, M.K, Bertrand, J. | Deposit date: | 2013-12-18 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA. Acta Crystallogr.,Sect.D, 70, 2014
|
|
8PC5
 
 | H3K36me3 nucleosome-LEDGF/p75 PWWP domain complex | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | Authors: | Koutna, E, Kouba, T, Veverka, V. | Deposit date: | 2023-06-09 | Release date: | 2023-08-16 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Multivalency of nucleosome recognition by LEDGF. Nucleic Acids Res., 51, 2023
|
|