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7JT9	Fgr SH3 domain crystal structure Descriptor: Tyrosine-protein kinase Fgr Authors: Perez, I, Berndt, S, Gurevich, V.V, Iverson, T.M. Deposit date: 2020-08-17 Release date: 2022-01-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr. J.Mol.Biol., 434, 2022
7CSR	Structure of Ephexin4 R676L Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-17 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSO	Structure of Ephexin4 DH-PH-SH3 Descriptor: Rho guanine nucleotide exchange factor 16, SULFATE ION Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CSP	Structure of Ephexin4 IDPSH Descriptor: Rho guanine nucleotide exchange factor 16 Authors: Zhang, M, Lin, L, Wang, C, Zhu, J. Deposit date: 2020-08-15 Release date: 2021-02-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc.Natl.Acad.Sci.USA, 118, 2021
7CFZ	SH3 domain of NADPH oxidase activator 1 Descriptor: NADPH oxidase activator 1 Authors: Kim, M, Park, J.H, Attri, P, Lee, W. Deposit date: 2020-06-29 Release date: 2021-07-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. Int.J.Biol.Macromol., 163, 2020
6XX4	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.05 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX3	Crystal structure of the c-Src SH3 domain H122R-Q128E mutant in complex with Cu(II) at pH 6.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.36 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX5	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Ni(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, NICKEL (II) ION, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-05-27 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XX2	Crystal structure of the c-Src SH3 domain H122R-Q128K mutant in complex with Cu(II) at pH 7.5 co-crystallized with methyl beta-cyclodextrin Descriptor: COPPER (II) ION, Cyclic 2,3-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-2,6-di-O-methyl-alpha-D-glucopyranose-(1-4)-2-O-methyl-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-3-O-methyl-alpha-D-glucopyranose, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2020-01-26 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.25 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVN	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 1 Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVM	Crystal structure of c-Src SH3 domain without ATCUN motif: monomer 2 Descriptor: GLYCEROL, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (0.9 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
6XVO	Crystal structure of the intertwined dimer of the c-Src SH3 domain without ATCUN motif Descriptor: DI(HYDROXYETHYL)ETHER, Proto-oncogene tyrosine-protein kinase Src, TRIETHYLENE GLYCOL Authors: Camara-Artigas, A, Plaza-Garrido, M. Deposit date: 2020-01-22 Release date: 2020-04-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The effect of an engineered ATCUN motif on the structure and biophysical properties of the SH3 domain of c-Src tyrosine kinase. J.Biol.Inorg.Chem., 25, 2020
5QU6	Crystal Structure of swapped human Nck SH3.1 domain, 1.8A, triclinic Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.816 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU8	Crystal Structure of symmetric swapped human Nck SH3.1 domain, 0.93A, orthorhombic form IV Descriptor: Cytoplasmic protein NCK1, SODIUM ION Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (0.93 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU3	Crystal Structure of domain swapped human Nck SH3.1, 1.01A, monoclinic Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.02 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QUA	Crystal Structure of swapped human Nck SH3.1 domain, 1.5A, C2221 Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU1	Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A Descriptor: Cytoplasmic protein NCK1, SULFATE ION Authors: Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.08 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU5	Domain Swap in the first SH3 domain of human Nck1 Descriptor: Cytoplasmic protein NCK1 Authors: Burger, D, Ruf, A, Benz, J, Schlatter, D, Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU2	Crystal Structure of human Nck SH3.1 in complex with peptide PPPVPNPDY Descriptor: ACE-PRO-PRO-PRO-VAL-PRO-ASN-PRO-ASP-TYR-NH2, Cytoplasmic protein NCK1, SULFATE ION Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.04 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU7	Crystal Structure of swapped human Nck SH3.1 domain, 1.3A, orthorhombic form III Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU4	Crystal Structure of swapped human Nck SH3.1 domain, 1.05A, orthorhombic form I Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
6UY7	Crystal structure of the STAC3 tandem SH3 domains - P269R Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3 Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.105 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
6UY9	Crystal structure of the STAC3 tandem SH3 domains - P269R, W284S Descriptor: 1,2-ETHANEDIOL, SH3 and cysteine-rich domain-containing protein 3, SODIUM ION Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
6UY8	Crystal structure of the STAC3 tandem SH3 domains - P269R, K329N Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SH3 and cysteine-rich domain-containing protein 3 Authors: Rufenach, B, Van Petegem, F. Deposit date: 2019-11-12 Release date: 2020-06-17 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.649 Å) Cite: Multiple Sequence Variants in STAC3 Affect Interactions with CaV1.1 and Excitation-Contraction Coupling. Structure, 28, 2020
6SDF	N-terminal SH3 domain of Grb2 protein Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Growth factor receptor-bound protein 2 Authors: Bolgov, A.A, Korban, S.A, Luzik, D.A, Rogacheva, O.N, Zhemkov, V.A, Kim, M, Skrynnikov, N.R, Bezprozvanny, I.B. Deposit date: 2019-07-26 Release date: 2020-01-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the SH3 domain of growth factor receptor-bound protein 2. Acta Crystallogr.,Sect.F, 76, 2020

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