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1BDH	PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) Authors: Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. Deposit date: 1996-07-25 Release date: 1997-04-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex J.Am.Chem.Soc., 118, 1996
6N7I	Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (gp4(5)-DNA) Descriptor: DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... Authors: Gao, Y, Cui, Y, Zhou, Z, Yang, W. Deposit date: 2018-11-27 Release date: 2019-03-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structures and operating principles of the replisome. Science, 363, 2019
1BDI	PURINE REPRESSOR MUTANT-HYPOXANTHINE-PALINDROMIC OPERATOR COMPLEX Descriptor: DNA (5'-D(*TP*AP*CP*GP*CP*AP*AP*AP*CP*GP*TP*TP*TP*GP*CP*GP*T )-3'), HYPOXANTHINE, PROTEIN (PURINE REPRESSOR) Authors: Glasfeld, A, Schumacher, M.A, Choi, K.Y, Zalkin, H, Brennan, R.G. Deposit date: 1996-07-25 Release date: 1997-04-21 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3 Å) Cite: A Positively Charged Residue Bound in the Minor Groove Does not Alter the Bending of a DNA Duplex J.Am.Chem.Soc., 118, 1996
5YEJ	Crystal structure of BioQ with its naturel double-stranded DNA operator Descriptor: DNA (5'-D(*AP*CP*CP*TP*GP*AP*AP*CP*AP*CP*CP*GP*TP*TP*CP*AP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*TP*GP*AP*AP*CP*GP*GP*TP*GP*TP*TP*CP*AP*GP*GP*T)-3'), TetR family transcriptional regulator Authors: Yan, L, Guan, Z.Y, Zou, T.T. Deposit date: 2017-09-17 Release date: 2018-09-26 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.698 Å) Cite: Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway. Biochim Biophys Acta Gen Subj, 1862, 2018
6A5L	RNA polymerase II elongation complex stalled at SHL(-1) of the nucleosome, with foreign DNA Descriptor: DNA (198-MER), DNA (42-MER), DNA-directed RNA polymerase subunit, ... Authors: Kujirai, T, Ehara, H, Fujino, Y, Shirouzu, M, Sekine, S, Kurumizaka, H. Deposit date: 2018-06-24 Release date: 2018-10-03 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (5.6 Å) Cite: Structural basis of the nucleosome transition during RNA polymerase II passage. Science, 362, 2018
7KSX	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mg2+ (30min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSY	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mg2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.577 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSW	DNA Polymerase Mu, dGTP:Ct Reaction State Ternary Complex, 10 mM Mg2+ (10min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSV	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mn2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KST	DNA Polymerase Mu, dGTP:Ct Reaction State Ternary Complex, 10 mM Mn2+ (2min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2021-12-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
4P9U	FadR, Fatty Acid Responsive Transcription Factor from Vibrio cholerae, in Complex with DNA Descriptor: DNA (31-MER), Fatty acid metabolism regulator protein Authors: Kull, F.J, Shi, W. Deposit date: 2014-04-05 Release date: 2015-02-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.208 Å) Cite: The 40-residue insertion in Vibrio cholerae FadR facilitates binding of an additional fatty acyl-CoA ligand. Nat Commun, 6, 2015
6N7V	Structure of bacteriophage T7 gp4 (helicase-primase, E343Q mutant) in complex with ssDNA, dTTP, AC dinucleotide, and CTP (from multiple lead complexes) Descriptor: DNA (93-MER), DNA primase/helicase, MAGNESIUM ION, ... Authors: Gao, Y, Fox, T, Val, N, Yang, W. Deposit date: 2018-11-28 Release date: 2019-03-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structures and operating principles of the replisome. Science, 363, 2019
7KT0	DNA Polymerase Mu, dGTP:At Ground State Ternary Complex, 50 mM Mg2+ (60min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.36 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT1	DNA Polymerase Mu, dGTP:At Reaction State Ternary Complex, 50 mM Mn2+ (180min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.665 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSU	DNA Polymerase Mu, dGTP:Ct Product State Ternary Complex, 10 mM Mn2+ (4min) Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KT2	DNA Polymerase Mu, dGTP:At Product State Ternary Complex, 50 mM Mn2+ (225min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7KSZ	DNA Polymerase Mu, dGTP:At Pre-Catalytic Ground State Ternary Complex, 10 mM Ca2+ (960min) Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... Authors: Jamsen, J.A, Wilson, S.H. Deposit date: 2020-11-24 Release date: 2022-01-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.417 Å) Cite: Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide. Nat Commun, 12, 2021
7VO0	Streptomyces coelicolor zinc uptake regulator complexed with zinc and DNA (trimer of dimers) Descriptor: DNA_NT (84-MER), DNA_T (84-MER), Putative metal uptake regulation protein, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-12 Release date: 2022-08-03 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
4PT4	Crystal structure Analysis of N terminal region containing the dimerization domain and DNA binding domain of HU protein(Histone like protein-DNA binding) from Mycobacterium tuberculosis [H37Ra] Descriptor: DNA-binding protein HU homolog, FORMIC ACID Authors: Bhowmick, T, Ramagopal, U.A, Ghosh, S, Nagaraja, V, Ramakumar, S. Deposit date: 2014-03-10 Release date: 2014-05-21 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors Nat Commun, 5, 2014
6SKO	Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation 2 MCM CTD:ssDNA Descriptor: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... Authors: Yeeles, J, Baretic, D, Jenkyn-Bedford, M. Deposit date: 2019-08-16 Release date: 2020-05-06 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork. Mol.Cell, 78, 2020
8QQI	E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800 Descriptor: DNA gyrase subunit A, DNA gyrase subunit B, MAGNESIUM ION, ... Authors: Ghilarov, D, Martin, N.I, van der Stelt, M. Deposit date: 2023-10-04 Release date: 2024-06-19 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria. Nat.Chem., 2024
7TQB	Crystal structure of monoclonal S9.6 Fab bound to DNA-RNA hybrid Descriptor: DNA, FAB S9.6 Heavy Chain, FAB S9.6 Light Chain, ... Authors: Bou-Nader, C, Zhang, J. Deposit date: 2022-01-26 Release date: 2022-03-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis of R-loop recognition by the S9.6 monoclonal antibody. Nat Commun, 13, 2022
6N7T	Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form III) Descriptor: DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... Authors: Gao, Y, Cui, Y, Zhou, Z, Yang, W. Deposit date: 2018-11-28 Release date: 2019-03-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structures and operating principles of the replisome. Science, 363, 2019
6N7S	Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form II) Descriptor: DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ... Authors: Gao, Y, Cui, Y, Zhou, Z, Yang, W. Deposit date: 2018-11-28 Release date: 2019-03-06 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structures and operating principles of the replisome. Science, 363, 2019
3CFO	Triple Mutant APO structure Descriptor: DNA polymerase, GUANOSINE, SULFATE ION Authors: Wang, J, Klimenko, D, Wang, M, Steitz, T.A, Konigsberg, W.H. Deposit date: 2008-03-04 Release date: 2009-03-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant To be Published

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