1YIG
 
 | | Crystal Structure of the Human EB1 C-terminal Dimerization Domain | | Descriptor: | Microtubule-associated protein RP/EB family member 1 | | Authors: | Slep, K.C, Rogers, S.L, Elliott, S.L, Ohkura, H, Kolodziej, P.A, Vale, R.D. | | Deposit date: | 2005-01-11 | | Release date: | 2005-03-08 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end
J.Cell Biol., 168, 2005
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5IZW
 | | Crystal structure of RNA editing specific factor of designer PLS-type PPR-9R protein | | Descriptor: | PLS9-PPR | | Authors: | Yan, J, Zhang, Q, Guan, Z, Zou, T, Yin, P. | | Deposit date: | 2016-03-26 | | Release date: | 2017-03-29 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.738 Å) | | Cite: | MORF9 increases the RNA-binding activity of PLS-type pentatricopeptide repeat protein in plastid RNA editing
Nat Plants, 3, 2017
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1YRF
 | | Chicken villin subdomain HP-35, N68H, pH6.7 | | Descriptor: | ACETATE ION, SULFATE ION, Villin | | Authors: | Chiu, T.K, Kubelka, J, Herbst-Irmer, R, Eaton, W.A, Hofrichter, J, Davies, D.R. | | Deposit date: | 2005-02-03 | | Release date: | 2005-05-03 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1UNL
 | | Structural mechanism for the inhibition of CD5-p25 from the roscovitine, aloisine and indirubin. | | Descriptor: | CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1, R-ROSCOVITINE | | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | | Deposit date: | 2003-09-10 | | Release date: | 2004-11-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
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1UNH
 | | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | | Descriptor: | (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME, CYCLIN-DEPENDENT KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | | Deposit date: | 2003-09-10 | | Release date: | 2004-11-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
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1UNG
 | | Structural mechanism for the inhibition of CDK5-p25 by roscovitine, aloisine and indirubin. | | Descriptor: | 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE, CELL DIVISION PROTEIN KINASE 5, CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 | | Authors: | Mapelli, M, Crovace, C, Massimiliano, L, Musacchio, A. | | Deposit date: | 2003-09-10 | | Release date: | 2004-11-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanism of Cdk5/P25 Binding by Cdk Inhibitors
J.Med.Chem., 48, 2005
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1XL3
 | | Complex structure of Y.pestis virulence Factors YopN and TyeA | | Descriptor: | Secretion control protein, protein type A | | Authors: | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | | Deposit date: | 2004-09-30 | | Release date: | 2005-03-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
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1ZAI
 | | Fructose-1,6-bisphosphate Schiff base intermediate in FBP aldolase from rabbit muscle | | Descriptor: | 1,6-FRUCTOSE DIPHOSPHATE (LINEAR FORM), Fructose-bisphosphate aldolase A | | Authors: | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | | Deposit date: | 2005-04-06 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit.
J.Biol.Chem., 280, 2005
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1Z7X
 | | X-ray structure of human ribonuclease inhibitor complexed with ribonuclease I | | Descriptor: | CITRIC ACID, Ribonuclease I, Ribonuclease inhibitor | | Authors: | McCoy, J.G, Johnson, R.J, Raines, R.T, Bitto, E, Bingman, C.A, Wesenberg, G.E, Allard, S.T.M, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | | Deposit date: | 2005-03-28 | | Release date: | 2005-06-21 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein.
J.Mol.Biol., 368, 2007
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1ZAJ
 | | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with mannitol-1,6-bisphosphate, a competitive inhibitor | | Descriptor: | D-MANNITOL-1,6-DIPHOSPHATE, Fructose-bisphosphate aldolase A | | Authors: | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | | Deposit date: | 2005-04-06 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit.
J.Biol.Chem., 280, 2005
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3TAD
 | | Crystal Structure of the Liprin-alpha/Liprin-beta complex | | Descriptor: | GLYCEROL, Liprin-alpha-2, Liprin-beta-1 | | Authors: | Wei, Z, Zheng, S, Yu, C, Zhang, M. | | Deposit date: | 2011-08-04 | | Release date: | 2011-10-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures
Mol.Cell, 43, 2011
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1YRI
 | | Chicken villin subdomain HP-35, N68H, pH6.4 | | Descriptor: | ACETATE ION, IODIDE ION, Villin | | Authors: | Chiu, T.K, Kubelka, J, Herbst-Irmer, R, Eaton, W.A, Hofrichter, J, Davies, D.R. | | Deposit date: | 2005-02-03 | | Release date: | 2005-05-03 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1 Å) | | Cite: | High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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1ZCB
 | | Crystal structure of G alpha 13 in complex with GDP | | Descriptor: | G alpha i/13, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Nance, M.R, Tesmer, J.J.G. | | Deposit date: | 2005-04-11 | | Release date: | 2005-11-15 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A new approach to producing functional G alpha subunits yields the activated and deactivated structures of G alpha(12/13) proteins.
Biochemistry, 45, 2006
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1XKP
 | | Crystal structure of the virulence factor YopN in complex with its heterodimeric chaperone SycN-YscB | | Descriptor: | Chaperone protein sycN, Chaperone protein yscB, putative membrane-bound Yop targeting protein YopN | | Authors: | Schubot, F.D, Jackson, M.W, Penrose, K.J, Cherry, S, Tropea, J.E, Plano, G.V, Waugh, D.S. | | Deposit date: | 2004-09-29 | | Release date: | 2005-03-22 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Three-dimensional structure of a macromolecular assembly that regulates type III secretion in Yersinia pestis.
J.Mol.Biol., 346, 2005
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1ZAH
 | | Fructose-1,6-bisphosphate aldolase from rabbit muscle | | Descriptor: | Fructose-bisphosphate aldolase A | | Authors: | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | | Deposit date: | 2005-04-06 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit.
J.Biol.Chem., 280, 2005
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1YV0
 | | Crystal structure of skeletal muscle troponin in the Ca2+-free state | | Descriptor: | MAGNESIUM ION, Troponin C, skeletal muscle, ... | | Authors: | Vinogradova, M.V, Stone, D.B, Malanina, G.G, Karatzaferi, C, Cooke, R, Mendelson, R.A, Fletterick, R.J. | | Deposit date: | 2005-02-14 | | Release date: | 2005-04-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (7 Å) | | Cite: | Ca2+-regulated structural changes in troponin
Proc.Natl.Acad.Sci.USA, 102, 2005
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1ZAL
 | | Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with partially disordered tagatose-1,6-bisphosphate, a weak competitive inhibitor | | Descriptor: | Fructose-bisphosphate aldolase A, PHOSPHATE ION | | Authors: | St-Jean, M, Lafrance-Vanasse, J, Liotard, B, Sygusch, J. | | Deposit date: | 2005-04-06 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | High Resolution Reaction Intermediates of Rabbit Muscle Fructose-1,6-bisphosphate Aldolase: substrate cleavage and induced fit.
J.Biol.Chem., 280, 2005
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1ZBJ
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1ZCA
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1YV3
 | | The structural basis of blebbistatin inhibition and specificity for myosin II | | Descriptor: | (-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Allingham, J.S, Smith, R, Rayment, I. | | Deposit date: | 2005-02-14 | | Release date: | 2005-03-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structural basis of blebbistatin inhibition and specificity for myosin II.
Nat.Struct.Mol.Biol., 12, 2005
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3BP7
 | | The high resolution crystal structure of HLA-B*2709 in complex with a Cathepsin A signal sequence peptide, pCatA | | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | Authors: | Kumar, P, Vahedi-Faridi, A, Saenger, W, Uchanska-Ziegler, B, Ziegler, A. | | Deposit date: | 2007-12-18 | | Release date: | 2008-12-23 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens
J.Biol.Chem., 284, 2009
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3K3B
 | | Co-crystal structure of the human kinesin Eg5 with a novel tetrahydro-beta-carboline | | Descriptor: | 3-[(1R)-2-acetyl-6-methyl-2,3,4,9-tetrahydro-1H-beta-carbolin-1-yl]phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Bussiere, D.E, Bellamacina, C, Le, V. | | Deposit date: | 2009-10-02 | | Release date: | 2009-12-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.
Bioorg.Med.Chem.Lett., 20, 2010
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3BPU
 | | Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and C709S double mutant | | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, ZINC ION | | Authors: | Pilka, E.S, Hozjan, V, Cooper, C, Pike, A.C.W, Elkins, J, Doyle, D.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Oppermann, U, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-12-19 | | Release date: | 2008-01-08 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and C709S double mutant.
To be Published
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3J8G
 | | Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit | | Descriptor: | 23S rRNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ... | | Authors: | Zhang, X, Yan, K, Zhang, Y, Li, N, Ma, C, Li, Z, Zhang, Y, Feng, B, Liu, J, Sun, Y, Xu, Y, Lei, J, Gao, N. | | Deposit date: | 2014-10-24 | | Release date: | 2014-11-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
Nucleic Acids Res., 2014
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3C3U
 | | Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid | | Descriptor: | 3,5-dichloro-2-hydroxybenzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Dhagat, U, El-Kabbani, O. | | Deposit date: | 2008-01-28 | | Release date: | 2008-08-26 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Selectivity determinants of inhibitor binding to human 20alpha-hydroxysteroid dehydrogenase: crystal structure of the enzyme in ternary complex with coenzyme and the potent inhibitor 3,5-dichlorosalicylic acid
J.Med.Chem., 51, 2008
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