1I31
 
 | | MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION | | Descriptor: | CLATHRIN COAT ASSEMBLY PROTEIN AP50, EPIDERMAL GROWTH FACTOR RECEPTOR | | Authors: | Modis, Y, Boll, W, Rapoport, I, Kirchhausen, T. | | Deposit date: | 2001-02-12 | | Release date: | 2001-02-21 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | MU2 ADAPTIN SUBUNIT (AP50) OF AP2 CLATHRIN ADAPTOR, COMPLEXED WITH EGFR INTERNALIZATION PEPTIDE FYRALM AT 2.5 A RESOLUTION
To be Published
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2V8S
 | | VTI1B HABC DOMAIN - EPSINR ENTH DOMAIN COMPLEX | | Descriptor: | CLATHRIN INTERACTOR 1, GLYCEROL, VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B | | Authors: | Owen, D.J, McCoy, A.J, Collins, B.M, Miller, S.E. | | Deposit date: | 2007-08-14 | | Release date: | 2007-11-27 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | A Snare-Adaptor Interaction is a New Mode of Cargo Recognition in Clathrin Coated Vesicles
Nature, 450, 2007
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1W63
 | | AP1 clathrin adaptor core | | Descriptor: | ADAPTER-RELATED PROTEIN COMPLEX 1 BETA 1 SUBUNIT, ADAPTER-RELATED PROTEIN COMPLEX 1 GAMMA 1 SUBUNIT, ADAPTER-RELATED PROTEIN COMPLEX 1 SIGMA 1A SUBUNIT, ... | | Authors: | Heldwein, E, Macia, E, Wang, J, Yin, H.L, Kirchhausen, T, Harrison, S.C. | | Deposit date: | 2004-08-12 | | Release date: | 2004-09-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal Structure of the Clathrin Adaptor Protein 1 Core
Proc.Natl.Acad.Sci.USA, 101, 2004
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1N4C
 | | NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin | | Descriptor: | Auxilin | | Authors: | Gruschus, J.M, Han, C.J, Greener, T, Greene, L.E, Ferretti, J.A, Eisenberg, E. | | Deposit date: | 2002-10-30 | | Release date: | 2003-11-11 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structure of the functional fragment of auxilin required for catalytic uncoating of clathrin-coated vesicles.
Biochemistry, 43, 2004
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4P6Z
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4HMY
 | | Structural basis for recruitment and activation of the AP-1 clathrin adaptor complex by Arf1 | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Ren, X, Farias, G.G, Canagarajah, B.J, Bonifacino, J.S, Hurley, J.H. | | Deposit date: | 2012-10-18 | | Release date: | 2013-03-06 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (7 Å) | | Cite: | Structural Basis for Recruitment and Activation of the AP-1 Clathrin Adaptor Complex by Arf1.
Cell(Cambridge,Mass.), 152, 2013
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3ZYL
 | | Structure of a truncated CALM (PICALM) ANTH domain | | Descriptor: | PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN | | Authors: | Miller, S.E, Sahlender, D.A, Graham, S.C, Honing, S, Robinson, M.S, Peden, A.A, Owen, D.J. | | Deposit date: | 2011-08-23 | | Release date: | 2011-12-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
Cell, 147, 2011
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3ZYM
 | | Structure of CALM (PICALM) in complex with VAMP8 | | Descriptor: | GLYCEROL, PHOSPHATE ION, PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN, ... | | Authors: | Miller, S.E, Sahlender, D.A, Graham, S.C, Honing, S, Robinson, M.S, Peden, A.A, Owen, D.J. | | Deposit date: | 2011-08-23 | | Release date: | 2011-12-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
Cell, 147, 2011
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3ZYK
 | | Structure of CALM (PICALM) ANTH domain | | Descriptor: | PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN | | Authors: | Miller, S.E, Sahlender, D.A, Graham, S.C, Honing, S, Robinson, M.S, Peden, A.A, Owen, D.J. | | Deposit date: | 2011-08-23 | | Release date: | 2011-12-07 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
Cell, 147, 2011
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3H85
 | | Molecular basis for the association of PIPKI gamma-p90 with the clathrin adaptor AP-2 | | Descriptor: | AP-2 complex subunit mu-1, NICKEL (II) ION, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | | Authors: | Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Haucke, V. | | Deposit date: | 2009-04-28 | | Release date: | 2009-11-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
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7R4H
 | | phospho-STING binding to adaptor protein complex-1 | | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | Authors: | Xu, P, Ablasser, A. | | Deposit date: | 2022-02-08 | | Release date: | 2022-09-14 | | Last modified: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (2.34 Å) | | Cite: | Clathrin-associated AP-1 controls termination of STING signalling.
Nature, 610, 2022
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2XA7
 | | AP2 clathrin adaptor core in active complex with cargo peptides | | Descriptor: | ADAPTOR-RELATED PROTEIN COMPLEX 2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA, ... | | Authors: | Jackson, L.P, Kelly, B.T, McCoy, A.J, Evans, P.R, Owen, D.J. | | Deposit date: | 2010-03-29 | | Release date: | 2010-07-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | A Large Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the Ap2 Clathrin Adaptor Complex
Cell(Cambridge,Mass.), 141, 2010
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3H1Z
 | | Molecular basis for the association of PIPKIgamma -p90 with the clathrin adaptor AP-2 | | Descriptor: | AP-2 complex subunit beta-1, Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | | Authors: | Vahedi-Faridi, A, Kahlfeldt, N, Schaefer, J.G, Krainer, G, Keller, S, Saenger, W, Krauss, M, Haucke, V. | | Deposit date: | 2009-04-14 | | Release date: | 2009-11-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Molecular basis for association of PIPKI gamma-p90 with clathrin adaptor AP-2.
J.Biol.Chem., 285, 2010
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2KIG
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2KIE
 | | A PH domain within OCRL bridges clathrin mediated membrane trafficking to phosphoinositide metabolis | | Descriptor: | Inositol polyphosphate 5-phosphatase OCRL-1 | | Authors: | Mao, Y, Balkin, D.M, Zoncu, R, Erdmann, K, Tomasini, L, Hu, F, Jin, M.M, Hodsdon, M.E, De Camilli, P. | | Deposit date: | 2009-05-03 | | Release date: | 2009-07-21 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism
Embo J., 28, 2009
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1W80
 | | Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2 peptides from Synaptojanin170 | | Descriptor: | ADAPTER-RELATED PROTEIN COMPLEX 2 ALPHA 2 SUBUNIT, BENZAMIDINE, CARBONATE ION, ... | | Authors: | Ford, M.G.J, Praefcke, G.J.K, McMahon, H.T. | | Deposit date: | 2004-09-14 | | Release date: | 2004-10-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Evolving Nature of the Ap2 Alpha-Appendage Hub During Clathrin-Coated Vesicle Endocytosis.
Embo J., 23, 2004
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6YAF
 | | AP2 on a membrane containing tyrosine-based cargo peptide | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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7RWA
 | | AP2 bound to heparin and Tgn38 tyrosine cargo peptide | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.
Nat.Struct.Mol.Biol., 29, 2022
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7RWC
 | | AP2 bound to the APA domain of SGIP and heparin; partial signal subtraction and symmetry expansion | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.
Nat.Struct.Mol.Biol., 29, 2022
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7RW8
 | | AP2 bound to heparin in the closed conformation | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.
Nat.Struct.Mol.Biol., 29, 2022
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7RWB
 | | AP2 bound to the APA domain of SGIP in the presence of heparin | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.
Nat.Struct.Mol.Biol., 29, 2022
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7RW9
 | | AP2 bound to heparin in the bowl conformation | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Baker, R.W, Hollopeter, G, Partlow, E.A. | | Deposit date: | 2021-08-19 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of an endocytic checkpoint that primes the AP2 clathrin adaptor for cargo internalization.
Nat.Struct.Mol.Biol., 29, 2022
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6YAE
 | | AP2 core in physiological buffer | | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kane Dickson, V, Kovtun, O, Kelly, B.T, Owen, D.J, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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6RH6
 | | Solution structure and 1H, 13C and 15N chemical shift assignments for the complex of NECAP1 PHear domain with phosphorylated AP2 mu2 148-163 | | Descriptor: | AP-2 complex subunit mu, Adaptin ear-binding coat-associated protein 1 | | Authors: | Owen, D.J, Neuhaus, D, Yang, J.-C, Herrmann, T. | | Deposit date: | 2019-04-18 | | Release date: | 2019-09-04 | | Method: | SOLUTION NMR | | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
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7ZX4
 | | Clathrin N-terminal domain in complex with a HURP phospho-peptide | | Descriptor: | CHLORIDE ION, Clathrin heavy chain 1, Disks large-associated protein 5, ... | | Authors: | Kliche, J, Badgujar, D, Dobritzsch, D, Ivarsson, Y. | | Deposit date: | 2022-05-20 | | Release date: | 2023-03-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Mol.Syst.Biol., 19, 2023
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