PDB: 64 resultsInfo pagesStatus searchChemie searchBIRD

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5L5P	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17 Descriptor: (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5D	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with ONX 0914 Descriptor: 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5I	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 9 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5A	Yeast 20S proteasome with human beta5i (1-138; R57T) Descriptor: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.4 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5U	Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17 Descriptor: 1,2,4-trideoxy-4-methyl-2-{[N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl]amino}-1-phenyl-D-xylitol, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5B	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) Descriptor: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5F	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with bortezomib Descriptor: CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5T	Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 16 Descriptor: (2~{S})-3-(1~{H}-indol-3-yl)-~{N}-[(2~{S},3~{S},4~{R})-4-methyl-3,5-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{R})-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5R	Yeast 20S proteasome with human beta5i (1-138;V31M) and human beta6 (97-111; 118-133) Descriptor: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5J	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 14 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5E	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with carfilzomib Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5M2B	Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with thiazole based inhibitor Ro19 Descriptor: (2~{S})-2-cyclohexyl-4-oxidanylidene-4-[[7-(4-phenyl-1,3-thiazol-2-yl)quinolin-2-yl]amino]butanoic acid, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M. Deposit date: 2016-10-12 Release date: 2017-01-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome. Chembiochem, 18, 2017
5LTT	Yeast 20S proteasome with human beta5i (1-138; R57T)in complex with PR-924 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-09-07 Release date: 2016-11-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016
5L5S	Yeast 20S proteasome with human beta5i (1-138; V31M) and human beta6 (97-111; 118-133) in complex with PR-924 Descriptor: CHLORIDE ION, MAGNESIUM ION, N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-N-[(2S,4R)-5-hydroxy-4-methyl-3-oxo-1-phenylpentan-2-yl]-L-tryptophanamide, ... Authors: Groll, M, Huber, E.M. Deposit date: 2016-05-28 Release date: 2016-11-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit beta 5i. EMBO J., 35, 2016

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