5M2B

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with thiazole based inhibitor Ro19

Summary for 5M2B

• Entry DOI: 10.2210/pdb5m2b/pdb
• Related: 5L5B
• Descriptor: Proteasome subunit alpha type-2, Proteasome subunit beta type-4, Proteasome subunit beta type-8,Proteasome subunit beta type-5, ... (18 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, proteasome, mutant, inhibitor, binding analysis, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 28
• Total formula weight: 732598.31

Authors

Groll, M. (deposition date: 2016-10-12, release date: 2017-01-25, Last modification date: 2024-01-17)

• Primary citation: Cui, H.,Baur, R.,Le Chapelain, C.,Dubiella, C.,Heinemeyer, W.,Huber, E.M.,Groll, M.; Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome.; Chembiochem, 18:523-526, 2017; PubMed: 28098422; DOI: 10.1002/cbic.201700021

Experimental method

X-RAY DIFFRACTION (2.7 Å)