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7NTK
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BU of 7ntk by Molmil
PALS1 PDZ1 domain with SARS-CoV-2_E PBM complex
Descriptor: 1,2-ETHANEDIOL, CITRATE ANION, Envelope small membrane protein, ...
Authors:Javorsky, A, Kvansakul, M.
Deposit date:2021-03-10
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain.
Commun Biol, 4, 2021
7NTJ
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BU of 7ntj by Molmil
PALS1 PDZ1 domain with SARS-CoV-1_E PBM complex
Descriptor: Envelope small membrane protein, MAGUK p55 subfamily member 5
Authors:Javorsky, A, Kvansakul, M.
Deposit date:2021-03-10
Release date:2021-06-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain.
Commun Biol, 4, 2021
7X2E
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BU of 7x2e by Molmil
Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail
Descriptor: Cadherin-related family member 2, GLYCEROL, Harmonin
Authors:Yan, W, Chen, G, Li, J.
Deposit date:2022-02-25
Release date:2022-07-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications.
Faseb J., 36, 2022
4XHV
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BU of 4xhv by Molmil
Crystal structure of Drosophila Spinophilin-PDZ and a C-terminal peptide of Neurexin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, LP20995p, ...
Authors:Driller, J.H, Muhammad, K.G.H, Reddy, S, Rey, U, Boehme, M.A, Hollmann, C, Ramesh, N, Depner, H, Luetzkendorf, J, Matkovic, T, Bergeron, D, Quentin, C, Schmoranzer, J, Goettfert, F, Holt, M, Wahl, M.C, Hell, S.W, Walter, A, Sigrist, S.J, Loll, B.
Deposit date:2015-01-06
Release date:2015-07-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function.
Nat Commun, 6, 2015
6MS1
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BU of 6ms1 by Molmil
Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC
Descriptor: 1,2-ETHANEDIOL, APC C-terminus peptide, Protein scribble homolog
Authors:How, J.Y, Kvansakul, M, Caria, S, Humbert, P.O.
Deposit date:2018-10-16
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC.
FEBS Lett., 593, 2019
6MYE
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BU of 6mye by Molmil
Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)
Descriptor: FORMIC ACID, Protein scribble homolog, Rho guanine nucleotide exchange factor 26, ...
Authors:Sun, Y.J, Hou, T, Gakhar, L, Fuentes, E.J.
Deposit date:2018-11-01
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
J.Cell Biol., 218, 2019
6MYF
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BU of 6myf by Molmil
Crystal structure of free human Scribble PDZ1 domain
Descriptor: Protein scribble homolog
Authors:Sun, Y.J, Hou, T, Gakhar, L, Fuentes, E.J.
Deposit date:2018-11-01
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
J.Cell Biol., 218, 2019
6NH9
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BU of 6nh9 by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain
Descriptor: Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-21
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:CASK PDZ domain specificity
To be published
5ZYS
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BU of 5zys by Molmil
Structure of Nephrin/MAGI1 complex
Descriptor: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, Nephrin
Authors:Weng, Z.F, Shng, Y, Zhu, J.W, Zhang, R.G.
Deposit date:2018-05-28
Release date:2019-01-23
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling.
J. Am. Soc. Nephrol., 29, 2018
4AMH
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BU of 4amh by Molmil
Influence of circular permutation on the folding pathway of a PDZ domain
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DISKS LARGE HOMOLOG 1, GLYCEROL
Authors:Hultqvist, G, Punekar, A.S, Chi, C.N, Selmer, M, Gianni, S, Jemth, P.
Deposit date:2012-03-10
Release date:2012-12-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tolerance of Protein Folding to a Circular Permutation in a Pdz Domain
Plos One, 7, 2012
6OV7
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BU of 6ov7 by Molmil
CFTR Associated Ligand (CAL) PDZ domain bound to peptide kCAL01
Descriptor: Golgi-associated PDZ and coiled-coil motif-containing protein, kCAL01 peptide
Authors:Gill, N.P, Madden, D.R.
Deposit date:2019-05-07
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Computational Analysis of Energy Landscapes Reveals Dynamic Features That Contribute to Binding of Inhibitors to CFTR-Associated Ligand.
J.Phys.Chem.B, 123, 2019
6HKS
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BU of 6hks by Molmil
Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide
Descriptor: IODIDE ION, Protein E6, Tyrosine-protein phosphatase non-receptor type 3
Authors:Genera, M, Haouz, A, Caillet-Saguy, C.
Deposit date:2018-09-07
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1944108 Å)
Cite:Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Sci Rep, 9, 2019
6V84
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BU of 6v84 by Molmil
CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALAc
Descriptor: GLYCEROL, Golgi-associated PDZ and coiled-coil motif-containing protein, LyCALAc
Authors:Gill, N.P, Madden, D.R.
Deposit date:2019-12-10
Release date:2021-02-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALAc
To Be Published
6AK2
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BU of 6ak2 by Molmil
Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018
Descriptor: Syntenin-1, peptide inhibitor KSL-128018
Authors:Jin, Z.Y, Park, J.H, Yun, J.H, Haugaard-Kedstrom, L.M, Lee, W.T.
Deposit date:2018-08-29
Release date:2019-09-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.868 Å)
Cite:A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma.
J.Med.Chem., 64, 2021
6AR4
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BU of 6ar4 by Molmil
Crystal structure of PICK1 in complex with the small molecule inhibitor 1o
Descriptor: N-[4-(4-bromophenyl)-1-{[2-(trifluoromethyl)phenyl]methyl}piperidine-4-carbonyl]-3-cyclopropyl-L-alanine, PRKCA-binding protein
Authors:Marcotte, D.
Deposit date:2017-08-21
Release date:2018-08-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction.
Sci Rep, 8, 2018
6NID
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BU of 6nid by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide
Descriptor: 1,2-ETHANEDIOL, Neurexin-1, Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-27
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:CASK PDZ domain specificity
To be published
4YYX
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BU of 4yyx by Molmil
Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail
Descriptor: FORMIC ACID, Tight junction protein ZO-1 fused with Claudin-2 C-terminal
Authors:Nomme, J, Lavie, A.
Deposit date:2015-03-24
Release date:2015-04-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.
J.Biol.Chem., 290, 2015
4Z33
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BU of 4z33 by Molmil
Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
Descriptor: ACETATE ION, D-MYO-INOSITOL-4,5-BISPHOSPHATE, GLYCEROL, ...
Authors:Egea-Jimenez, A.L, Gallardo, R, Garcia-Pino, A, Ivarsson, Y, Wawrzyniak, A.M, Kashyap, R, Loris, R, Schymkowitz, J, Rousseau, F, Zimmermann, P.
Deposit date:2015-03-30
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
To Be Published
4Z8J
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BU of 4z8j by Molmil
Crystal structure of the SNX27 PDZ domain bound to the C-terminal PTHR PDZ binding motif
Descriptor: C-terminal PDZ binding motif from parathyroid hormone receptor (PTHR), Sorting nexin-27
Authors:Clairfeuille, T, Pavlos, N, Collins, B.M.
Deposit date:2015-04-09
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Role of SNX27-retromer in PTHR trafficking
To Be Published
6UBH
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BU of 6ubh by Molmil
Structure of the MM7 Erbin PDZ variant in complex with a high-affinity peptide
Descriptor: Erbin, SODIUM ION, peptide
Authors:Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S.
Deposit date:2019-09-11
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain.
J.Mol.Biol., 433, 2021
6GBD
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BU of 6gbd by Molmil
Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain
Descriptor: PDZ3
Authors:Kock, G, Stoll, R.
Deposit date:2018-04-13
Release date:2018-12-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.
J. Mol. Biol., 430, 2018
6GBE
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BU of 6gbe by Molmil
Murine Protein Tyrosine Phosphatase PTPN13 PDZ3 Domain-PRK2 Peptide Complex
Descriptor: Serine/threonine-protein kinase N2, Tyrosine-protein phosphatase non-receptor type 13
Authors:Kock, G, Stoll, R.
Deposit date:2018-04-13
Release date:2018-12-05
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.
J. Mol. Biol., 430, 2018
4YDP
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BU of 4ydp by Molmil
Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.
Descriptor: GLUTAMIC ACID, LEUCINE, LIM domain-binding protein 3
Authors:Grishkovskaya, I, Onipe, A, Kontaxis, G, Djinovic-Carugo, K.
Deposit date:2015-02-22
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of N-terminal PDZ domain of ZASP in complex with myotilin C-terminal peptide.
To Be Published
6BJO
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BU of 6bjo by Molmil
PICK1 PDZ domain in complex with the small molecule inhibitor BIO124.
Descriptor: (2S)-({4-(4-bromophenyl)-1-[1-(tert-butoxycarbonyl)-L-prolyl]piperidine-4-carbonyl}amino)(cyclopentyl)acetic acid, PRKCA-binding protein
Authors:Marcotte, D.J.
Deposit date:2017-11-06
Release date:2018-01-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
Protein Sci., 27, 2018
6BJN
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BU of 6bjn by Molmil
PICK1 PDZ domain in complex with the class I PDZ binding motif QSAV
Descriptor: PRKCA-binding protein
Authors:Marcotte, D.J.
Deposit date:2017-11-06
Release date:2018-01-10
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure.
Protein Sci., 27, 2018

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PDB entries from 2024-06-26

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