5ZYS
Structure of Nephrin/MAGI1 complex
Summary for 5ZYS
| Entry DOI | 10.2210/pdb5zys/pdb |
| Descriptor | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, Nephrin (3 entities in total) |
| Functional Keywords | slit diaphragm, nephrotic syndrome, magi1- nephrin complex, cell adhesion |
| Biological source | Mus musculus (Mouse) More |
| Total number of polymer chains | 2 |
| Total formula weight | 11758.45 |
| Authors | Weng, Z.F.,Shng, Y.,Zhu, J.W.,Zhang, R.G. (deposition date: 2018-05-28, release date: 2019-01-23, Last modification date: 2024-03-27) |
| Primary citation | Weng, Z.,Shang, Y.,Ji, Z.,Ye, F.,Lin, L.,Zhang, R.,Zhu, J. Structural Basis of Highly Specific Interaction between Nephrin and MAGI1 in Slit Diaphragm Assembly and Signaling. J. Am. Soc. Nephrol., 29:2362-2371, 2018 Cited by PubMed Abstract: The slit diaphragm is a specialized adhesion junction between opposing podocytes, establishing the final filtration barrier that prevents passage of proteins from the capillary lumen into the urinary space. Nephrin, the key structural and signaling adhesion molecule expressed in the slit diaphragm, contains an evolutionally conserved, atypical PDZ-binding motif (PBM) reported to bind to a variety of proteins in the slit diaphragm. Several mutations in (the gene encoding nephrin) that result in nephrin lacking an intact PBM are associated with glomerular diseases. However, the molecular basis of nephrin-PBM-mediated protein complexes is still unclear. PubMed: 30006415DOI: 10.1681/ASN.2017121275 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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