5HL7
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![BU of 5hl7 by Molmil](/molmil-images/mine/5hl7) | The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Eyal, Z, Matzov, D, Krupkin, M, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2016-01-14 | Release date: | 2016-12-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism. Sci Rep, 6, 2016
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7PRT
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![BU of 7prt by Molmil](/molmil-images/mine/7prt) | Crystal structure of human heparanase in complex with covalent inhibitor CB678 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-alpha-D-arabino-hexopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, ... | Authors: | Wu, L, Armstrong, Z, Davies, G.J. | Deposit date: | 2021-09-22 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PRB
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![BU of 7prb by Molmil](/molmil-images/mine/7prb) | Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor GR109 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Glyco_hydro_44 domain-containing protein | Authors: | Wu, L, Armstrong, Z, Davies, G.J. | Deposit date: | 2021-09-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PSK
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![BU of 7psk by Molmil](/molmil-images/mine/7psk) | Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor GR109 | Descriptor: | 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase | Authors: | Armstrong, Z, Wu, L, Davies, G.J. | Deposit date: | 2021-09-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PSJ
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![BU of 7psj by Molmil](/molmil-images/mine/7psj) | Crystal structure of beta-glucuronidase from Acidobacterium capsulatum in complex with covalent inhibitor VL166 | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase | Authors: | Armstrong, Z, Wu, L, Davies, G.J. | Deposit date: | 2021-09-23 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PR9
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![BU of 7pr9 by Molmil](/molmil-images/mine/7pr9) | Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor VL166 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Glyco_hydro_44 domain-containing protein | Authors: | Wu, L, Armstrong, Z, Davies, G.J. | Deposit date: | 2021-09-21 | Release date: | 2022-08-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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5J8A
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![BU of 5j8a by Molmil](/molmil-images/mine/5j8a) | Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-04-07 | Release date: | 2016-07-06 | Last modified: | 2016-08-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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5I4L
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![BU of 5i4l by Molmil](/molmil-images/mine/5i4l) | Crystal structure of Amicoumacin A bound to the yeast 80S ribosome | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | Authors: | Prokhorova, I.V, Yusupova, G, Yusupov, M. | Deposit date: | 2016-02-12 | Release date: | 2016-06-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome. Sci Rep, 6, 2016
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5JC9
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![BU of 5jc9 by Molmil](/molmil-images/mine/5jc9) | Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-04-14 | Release date: | 2016-07-06 | Last modified: | 2016-08-03 | Method: | X-RAY DIFFRACTION (3.03 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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5J7L
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![BU of 5j7l by Molmil](/molmil-images/mine/5j7l) | Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-04-06 | Release date: | 2016-07-27 | Last modified: | 2018-08-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HCR
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![BU of 5hcr by Molmil](/molmil-images/mine/5hcr) | Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Gagnon, M.G, Roy, R.N, Lomakin, I.B, Florin, T, Mankin, A.S, Steitz, T.A. | Deposit date: | 2016-01-04 | Release date: | 2016-04-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res., 44, 2016
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7SBX
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![BU of 7sbx by Molmil](/molmil-images/mine/7sbx) | Structure of OC43 spike in complex with polyclonal Fab6 (Donor 1051) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-26 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SBY
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![BU of 7sby by Molmil](/molmil-images/mine/7sby) | Structure of OC43 spike in complex with polyclonal Fab7 (Donor 269) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-26 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SB3
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![BU of 7sb3 by Molmil](/molmil-images/mine/7sb3) | Structure of OC43 spike in complex with polyclonal Fab1 (Donor 269) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Ward, A, Bangaru, S, Antanasijevic, A. | Deposit date: | 2021-09-23 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SB4
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![BU of 7sb4 by Molmil](/molmil-images/mine/7sb4) | Structure of OC43 spike in complex with polyclonal Fab2 (Donor 1412) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-23 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SB5
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![BU of 7sb5 by Molmil](/molmil-images/mine/7sb5) | Structure of OC43 spike in complex with polyclonal Fab3 (Donor 1412) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-23 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SBV
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![BU of 7sbv by Molmil](/molmil-images/mine/7sbv) | Structure of OC43 spike in complex with polyclonal Fab4 (Donor 269) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-26 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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7SBW
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![BU of 7sbw by Molmil](/molmil-images/mine/7sbw) | Structure of OC43 spike in complex with polyclonal Fab5 (Donor 1051) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Human polyclonal Fab model with polyalanine backbone - Heavy chain, ... | Authors: | Bangaru, S, Antanasijevic, A, Ward, A. | Deposit date: | 2021-09-26 | Release date: | 2022-05-04 | Last modified: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural mapping of antibody landscapes to human betacoronavirus spike proteins. Sci Adv, 8, 2022
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5JVG
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![BU of 5jvg by Molmil](/molmil-images/mine/5jvg) | The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 50S ribosomal protein L11, ... | Authors: | Krupkin, M, Wekselman, I, Matzov, D, Eyal, Z, Diskin Posner, Y, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | Deposit date: | 2016-05-11 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.428 Å) | Cite: | Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc.Natl.Acad.Sci.USA, 113, 2016
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2RSK
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![BU of 2rsk by Molmil](/molmil-images/mine/2rsk) | RNA aptamer against prion protein in complex with the partial binding peptide | Descriptor: | RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3'), partial binding peptide of Major prion protein | Authors: | Mashima, T, Nishikawa, F, Kamatari, Y.O, Fujiwara, H, Nishikawa, S, Kuwata, K, Katahira, M. | Deposit date: | 2012-03-08 | Release date: | 2013-02-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Anti-prion activity of an RNA aptamer and its structural basis Nucleic Acids Res., 41, 2013
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5IB7
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![BU of 5ib7 by Molmil](/molmil-images/mine/5ib7) | Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rozov, A, Demeshkina, N, Yusupov, M, Yusupova, G. | Deposit date: | 2016-02-22 | Release date: | 2016-05-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | The ribosome prohibits the GU wobble geometry at the first position of the codon-anticodon helix. Nucleic Acids Res., 44, 2016
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2ON5
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![BU of 2on5 by Molmil](/molmil-images/mine/2on5) | Structure of NaGST-2 | Descriptor: | 1,2-ETHANEDIOL, GLUTATHIONE, Na Glutathione S-transferase 2 | Authors: | Asojo, O.A, Ngamelue, M, Homma, H, Goud, G, Zhan, B, Hotez, P.J. | Deposit date: | 2007-01-23 | Release date: | 2007-08-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus Bmc Struct.Biol., 7, 2007
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5HCQ
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![BU of 5hcq by Molmil](/molmil-images/mine/5hcq) | Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Gagnon, M.G, Roy, R.N, Lomakin, I.B, Florin, T, Mankin, A.S, Steitz, T.A. | Deposit date: | 2016-01-04 | Release date: | 2016-04-06 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.801 Å) | Cite: | Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Nucleic Acids Res., 44, 2016
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2OM0
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![BU of 2om0 by Molmil](/molmil-images/mine/2om0) | Structure of human insulin in presence of urea at pH 6.5 | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Norrman, M, Schluckebier, G. | Deposit date: | 2007-01-20 | Release date: | 2007-12-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH. Bmc Struct.Biol., 7, 2007
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5J8B
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![BU of 5j8b by Molmil](/molmil-images/mine/5j8b) | Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Gagnon, M.G, Lin, J, Steitz, T.A. | Deposit date: | 2016-04-07 | Release date: | 2016-05-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Elongation factor 4 remodels the A-site tRNA on the ribosome. Proc.Natl.Acad.Sci.USA, 113, 2016
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