PDB: 46984 resultsInfo pagesStatus searchChemie searchBIRD

---

5GMT	Crystal structure of the marine PL-14 alginate lyase from Aplysia kurodai Descriptor: Alginate lyase Authors: Qin, H.-M, Miyakawa, T, Nakamura, A, Tanokura, M. Deposit date: 2016-07-16 Release date: 2017-01-04 Last modified: 2020-02-26 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structure and Polymannuronate Specificity of a Eukaryotic Member of Polysaccharide Lyase Family 14. J. Biol. Chem., 292, 2017
1WGG	Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14) Descriptor: Ubiquitin carboxyl-terminal hydrolase 14 Authors: Zhao, C, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-28 Release date: 2004-11-28 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution Structure of the N-terminal Ubiquitin-like Domain of Mouse Ubiquitin Specific Protease 14 (USP14) To be Published
5EAH	Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Difenoconazole Descriptor: 1-[[(2~{R},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, 1-[[(2~{R},4~{S})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, 1-[[(2~{S},4~{R})-2-[2-chloranyl-4-(4-chloranylphenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole, ... Authors: Tyndall, J.D.A, Sabherwal, M, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. Deposit date: 2015-10-16 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.541 Å) Cite: Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals. PLoS ONE, 11, 2016
5ICS	Crystal structure of 17beta-hydroxysteroid dehydrogenase type 14 apoenzyme. Descriptor: 17-beta-hydroxysteroid dehydrogenase 14 Authors: Bertoletti, N, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-02-23 Release date: 2016-07-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.52 Å) Cite: New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59, 2016
6YOX	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-027 Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Wolter, M, Ottmann, C. Deposit date: 2020-04-15 Release date: 2020-09-23 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
5JS6	Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD. Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Bertoletti, N, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-05-07 Release date: 2016-07-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.002 Å) Cite: New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59, 2016
7O07	14-3-3sigma covalently bound to peptide (chloroacetamide-Cys interaction) Descriptor: 14-3-3 protein sigma, MAGNESIUM ION, Transcriptional coactivator YAP1 Authors: Somsen, B.A, Ottmann, C. Deposit date: 2021-03-25 Release date: 2021-10-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Covalent flexible peptide docking in Rosetta. Chem Sci, 12, 2021
5L7T	17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor. Descriptor: (4-fluoranyl-3-oxidanyl-phenyl)-[6-(3-methyl-4-oxidanyl-phenyl)pyridin-2-yl]methanone, 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-06-03 Release date: 2016-12-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.983 Å) Cite: First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59, 2016
5L7Y	17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor. Descriptor: (4-fluoranyl-3-oxidanyl-phenyl)-[6-(2-fluoranyl-3-oxidanyl-phenyl)pyridin-2-yl]methanone, 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-06-04 Release date: 2016-12-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.912 Å) Cite: First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59, 2016
5L7W	17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor. Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... Authors: Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-06-04 Release date: 2016-12-21 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.76 Å) Cite: First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59, 2016
8VZ7	Crystal Structure of Human Cytochrome P450 2C9*27 (R150L) Genetic Variant in Complex with the Drug Losartan Descriptor: Cytochrome P450 2C9, POTASSIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Shah, M.B. Deposit date: 2024-02-11 Release date: 2024-06-12 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan. J.Inorg.Biochem., 258, 2024
5JSF	Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 S205 variant in complex with NAD. Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Bertoletti, N, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-05-08 Release date: 2016-07-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.842 Å) Cite: New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59, 2016
1KP8	Structural Basis for GroEL-assisted Protein Folding from the Crystal Structure of (GroEL-KMgATP)14 at 2.0 A Resolution Descriptor: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, POTASSIUM ION, ... Authors: Wang, J. Deposit date: 2001-12-30 Release date: 2003-03-25 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural Basis for GroEL-assisted Protein Folding from the Crystal Structure of (GroEL-KMgATP)14 at 2.0 A Resolution J.Mol.Biol., 327, 2003
2B0F	NMR Structure of the Human Rhinovirus 3C Protease (serotype 14) with covalently bound Ace-LEALFQ-ethylpropionate inhibitor Descriptor: Ace-LEALFQ-ethylpropionate, Protease 3C Authors: Bjorndahl, T.C, Andrew, L.C, Wishart, D.S. Deposit date: 2005-09-13 Release date: 2006-09-05 Last modified: 2023-11-15 Method: SOLUTION NMR Cite: NMR solution structures of the apo and peptide-inhibited human rhinovirus 3C protease (Serotype 14): structural and dynamic comparison Biochemistry, 46, 2007
5ULO	Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein zeta/delta, L-PROLINAMIDE, ... Authors: DONG, A, HU, J, MADIGAN, J, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, TONG, Y, Structural Genomics Consortium (SGC) Deposit date: 2017-01-25 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal Structure of 14-3-3 zeta in Complex with a Serine 124-phosphorylated TBC1D7 peptide to be published
4G3J	Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [R-VNI-triazole (VNT)] Descriptor: N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, sterol 14-alpha-demethylase Authors: Hargrove, T.Y, Wawrzak, Z, Waterman, M.R, Lepesheva, G.I. Deposit date: 2012-07-14 Release date: 2013-07-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis, 212, 2015
4G7G	Sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in complex with the VNI derivative (R)-N-(1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide [VNI/VNF (VFV)] Descriptor: N-[(1R)-1-(3,4'-difluorobiphenyl-4-yl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE, sterol 14-alpha-demethylase Authors: Hargrove, T.Y, Wawrzak, Z, Waterman, M.R, Lepesheva, G.I. Deposit date: 2012-07-20 Release date: 2013-07-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis. J Infect Dis, 212, 2015
5HLE	Structural basis of backwards motion in kinesin-14: minus-end directed nKn664 in the ADP state Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Protein claret segregational,Minus-end kinesin-1/kinesin-14,Protein claret segregational Authors: Nitta, R. Deposit date: 2016-01-14 Release date: 2017-01-25 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Backwards motion in kinesin-14 requires neck-mimic to control a neck-helix swing. To Be Published
7ORS	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 Descriptor: (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... Authors: Centorrino, F, Wu, Q, Ottmann, C. Deposit date: 2021-06-06 Release date: 2022-06-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7OQU	Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ180 Descriptor: (2~{S},3~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]-3-methyl-2,3-dihydro-1-benzofuran-2-carboxamide, 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-06-04 Release date: 2022-06-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
5EAG	Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor Prochloraz Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Prochloraz Authors: Tyndall, J.D.A, Sabherwal, M, Sagatova, A.A, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. Deposit date: 2015-10-16 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals. PLoS ONE, 11, 2016
5EAD	Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor S-desthio-prothioconazole Descriptor: (2~{S})-2-(1-chloranylcyclopropyl)-1-(2-chlorophenyl)-3-(1,2,4-triazol-1-yl)propan-2-ol, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE Authors: Tyndall, J.D.A, Sabherwal, M, Sagatova, A.A, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. Deposit date: 2015-10-16 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals. PLoS ONE, 11, 2016
5EAC	Saccharomyces cerevisiae CYP51 complexed with the plant pathogen inhibitor R-tebuconazole Descriptor: (3~{R})-1-(4-chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazol-1-ylmethyl)pentan-3-ol, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE Authors: Tyndall, J.D.A, Sabherwal, M, Sagatova, A.A, Keniya, M.V, Wilson, R.K, Woods, M.V, Monk, B.C. Deposit date: 2015-10-16 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural and Functional Elucidation of Yeast Lanosterol 14 alpha-Demethylase in Complex with Agrochemical Antifungals. PLoS ONE, 11, 2016
5ICM	17beta-hydroxysteroid dehydrogenase type 14 in complex with a non-steroidal inhibitor Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... Authors: Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2016-02-23 Release date: 2016-07-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.68 Å) Cite: New Insights into Human 17 beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor. J.Med.Chem., 59, 2016
5EN4	Complex of 17-beta-hydroxysteroid dehydrogenase type 14 with inhibitor. Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... Authors: Bertoletti, N, Braun, F, Marchais-Oberwinkler, S, Heine, A, Klebe, G. Deposit date: 2015-11-09 Release date: 2016-11-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.52 Å) Cite: First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59, 2016

<22232425262728293031323334353637>