5L7W
17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor.
Summary for 5L7W
Entry DOI | 10.2210/pdb5l7w/pdb |
Descriptor | 17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total) |
Functional Keywords | hydroxysteroid dehydrogenase, inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9BPX1 |
Total number of polymer chains | 1 |
Total formula weight | 29892.59 |
Authors | Bertoletti, N.,Braun, F.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (deposition date: 2016-06-04, release date: 2016-12-21, Last modification date: 2024-01-10) |
Primary citation | Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Steinmetzer, T.,Salah, M.,Abdelsamie, A.S.,van Koppen, C.J.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59:10719-10737, 2016 Cited by PubMed: 27933965DOI: 10.1021/acs.jmedchem.6b01436 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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