5L7W

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal inhibitor.

Summary for 5L7W

Entry DOI	10.2210/pdb5l7w/pdb
Descriptor	17-beta-hydroxysteroid dehydrogenase 14, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SODIUM ION, ... (6 entities in total)
Functional Keywords	hydroxysteroid dehydrogenase, inhibitor complex, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q9BPX1
Total number of polymer chains	1
Total formula weight	29892.59
Authors	Bertoletti, N.,Braun, F.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (deposition date: 2016-06-04, release date: 2016-12-21, Last modification date: 2024-01-10)
Primary citation	Braun, F.,Bertoletti, N.,Moller, G.,Adamski, J.,Steinmetzer, T.,Salah, M.,Abdelsamie, A.S.,van Koppen, C.J.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S. First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. J. Med. Chem., 59:10719-10737, 2016 Cited by PubMed: 27933965 DOI: 10.1021/acs.jmedchem.6b01436 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation