PDB: 1731 resultsInfo pagesStatus searchChemie searchBIRD

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6FSH	Crystal structure of hybrid P450 OxyBtei(BC/FGvan) Descriptor: ACETATE ION, OxyB protein, POTASSIUM ION, ... Authors: Brieke, C, Tarnawski, M, Greule, A, Cryle, M.J. Deposit date: 2018-02-19 Release date: 2018-05-23 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Investigating Cytochrome P450 specificity during glycopeptide antibiotic biosynthesis through a homologue hybridization approach. J. Inorg. Biochem., 185, 2018
1JPZ	Crystal structure of a complex of the heme domain of P450BM-3 with N-Palmitoylglycine Descriptor: BIFUNCTIONAL P-450:NADPH-P450 REDUCTASE, N-PALMITOYLGLYCINE, PROTOPORPHYRIN IX CONTAINING FE Authors: Haines, D.C, Tomchick, D.R, Machius, M, Peterson, J.A. Deposit date: 2001-08-03 Release date: 2001-11-09 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Pivotal role of water in the mechanism of P450BM-3. Biochemistry, 40, 2001
1WIY	Crystal Structure Analysis of a 6-coordinated Cytochorome P450 from Thermus thermophilus HB8 Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Kousumi, Y, Nakagawa, N, Kaneko, M, Yamamoto, H, Masui, R, Kuramitsu, S, Ueyama, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-28 Release date: 2004-11-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure Analysis of Cytochrome P450 from Thermus thermophilus HB8 To be Published
4UAX	X-ray crystal structure of ligand free CYP142A2 from Mycobacterium smegmatis Descriptor: P450 heme-thiolate protein, PROTOPORPHYRIN IX CONTAINING FE Authors: Madrona, Y. Deposit date: 2014-08-11 Release date: 2014-09-17 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Cholesterol ester oxidation by mycobacterial cytochrome p450. J.Biol.Chem., 289, 2014
4KEW	structure of the A82F BM3 heme domain in complex with omeprazole Descriptor: 6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfanyl}-1H-benzimidazole, Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE Authors: Leys, D. Deposit date: 2013-04-26 Release date: 2013-07-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Key Mutations Alter the Cytochrome P450 BM3 Conformational Landscape and Remove Inherent Substrate Bias. J.Biol.Chem., 288, 2013
2FDU	Microsomal P450 2A6 with the inhibitor N,N-Dimethyl(5-(pyridin-3-yl)furan-2-yl)methanamine bound Descriptor: Cytochrome P450 2A6, N,N-DIMETHYL(5-(PYRIDIN-3-YL)FURAN-2-YL)METHANAMINE, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Yano, J.K, Stout, C.D, Johnson, E.F. Deposit date: 2005-12-14 Release date: 2006-11-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization. J.Med.Chem., 49, 2006
8CKN	Cytochrome P450 CYP143A1 (Rv1785c) from Mycobacterium tuberculosis Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Selvam, I.R. Deposit date: 2023-02-16 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (1.54 Å) Cite: 1.54 Angstrom structure of cytochrome P450 CYP143A1 (Rv1785c) from Mycobacterium tuberculosis To Be Published
3EJE	Crystal Structure of P450BioI in complex with octadec-9Z-enoic acid ligated Acyl Carrier Protein Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Cryle, M.J, Schlichting, I. Deposit date: 2008-09-18 Release date: 2008-10-07 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJD	Crystal Structure of P450BioI in complex with hexadec-9Z-enoic acid ligated Acyl Carrier Protein Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ... Authors: Cryle, M.J, Schlichting, I. Deposit date: 2008-09-18 Release date: 2008-10-07 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
3EJB	Crystal Structure of P450BioI in complex with tetradecanoic acid ligated Acyl Carrier Protein Descriptor: Acyl carrier protein, Biotin biosynthesis cytochrome P450-like enzyme, CHLORIDE ION, ... Authors: Cryle, M.J, Schlichting, I. Deposit date: 2008-09-18 Release date: 2008-10-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc.Natl.Acad.Sci.Usa, 105, 2008
5WK9	R186AP450cam with CN and camphor Descriptor: CAMPHOR, CYANIDE ION, Camphor 5-monooxygenase, ... Authors: Poulos, T.L, Batabyal, D. Deposit date: 2017-07-24 Release date: 2017-09-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.983 Å) Cite: Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
5WK7	P450cam mutant R186A Descriptor: 5-EXO-HYDROXYCAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... Authors: Batabyal, D, Poulos, T.L. Deposit date: 2017-07-24 Release date: 2017-09-06 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.983 Å) Cite: Effect of Redox Partner Binding on Cytochrome P450 Conformational Dynamics. J. Am. Chem. Soc., 139, 2017
8HGT	Crystal structure of the CYP153A mutant V456A from Marinobacter aquaeolei Descriptor: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE Authors: Jiang, Y, Tian, X, Cong, Z. Deposit date: 2022-11-15 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Enabling Peroxygenase Activity in Cytochrome P450 Monooxygenases by Engineering Hydrogen Peroxide Tunnels. J.Am.Chem.Soc., 145, 2023
2C7X	Crystal structure of narbomycin-bound cytochrome P450 PikC (CYP107L1) Descriptor: CYTOCHROME P450 MONOOXYGENASE, NARBOMYCIN, PROTOPORPHYRIN IX CONTAINING FE Authors: Sherman, D.H, Li, S, Yermalitskaya, L.V, Kim, Y, Smith, J.A, Waterman, M.R, Podust, L.M. Deposit date: 2005-11-29 Release date: 2006-07-03 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The Structural Basis for Substrate Anchoring, Active Site Selectivity, and Product Formation by P450 Pikc from Streptomyces Venezuelae. J.Biol.Chem., 281, 2006
6KZS	Crystal structure of cytochrome P450mel 107F1 in complex with heme and imidazole Descriptor: Cytochrome P-450, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE Authors: Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L. Deposit date: 2019-09-25 Release date: 2020-09-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.601 Å) Cite: Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity To Be Published
6KZT	Crystal structure of cytochrome P450mel 107F1 with biaryl coupling reactivity Descriptor: Cytochrome P-450, PROTOPORPHYRIN IX CONTAINING FE Authors: Hou, X.D, Rao, Y.J, Icyishaka, P, Li, C.X, Lou, J.L. Deposit date: 2019-09-25 Release date: 2020-09-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Crystallization and X-ray analysis of cytochrome P450mel 107F1 with biaryl coupling reactivity To Be Published
6MI0	Crystal structure of the P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus, ligand-free state Descriptor: Cytochrome P450 51, PROTOPORPHYRIN IX CONTAINING FE Authors: Hargrove, T, Wawrzak, Z, Lamb, D.C, Lepesheva, G.I. Deposit date: 2018-09-18 Release date: 2019-07-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Concerning P450 evolution: Structural Analyses Support Bacterial Origin of Sterol 14 alpha-Demethylases. Mol.Biol.Evol., 2020
4FIA	Crystal Structure of Human CYP46A1 P450 with bicalutamide Bound Descriptor: Cholesterol 24-hydroxylase, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: Stout, C.D, Pikuleva, I.A, Mast, N. Deposit date: 2012-06-08 Release date: 2013-01-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J.Biol.Chem., 288, 2013
7SNM	Lanosterol-bound P450 domain of the CYP51-ferredoxin fusion protein from Methylococcus capsulatus Descriptor: Cytochrome P450 51, LANOSTEROL, PROTOPORPHYRIN IX CONTAINING FE Authors: Lepesheva, G.I, Hargrove, T, Wawrzak, Z. Deposit date: 2021-10-28 Release date: 2022-10-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Unravelling the role of transient redox partner complexes in P450 electron transfer mechanics. Sci Rep, 12, 2022
2VZM	Crystal structure of the narbomycin-bound PikC D50N mutant Descriptor: CYTOCHROME P450 MONOOXYGENASE, NARBOMYCIN, PROTOPORPHYRIN IX CONTAINING FE Authors: Li, S, Sherman, D.H, Podust, L.M. Deposit date: 2008-08-01 Release date: 2008-08-12 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Analysis of Transient and Catalytic Desosamine Binding Pockets in Cytochrome P450 Pikc from Streptomyces Venezuelae. J.Biol.Chem., 284, 2009
3ABB	Crystal structure of CYP105D6 Descriptor: Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE Authors: Xu, L.H, Fushinobu, S, Takamatsu, S, Wakagi, T, Ikeda, H, Shoun, H. Deposit date: 2009-12-04 Release date: 2010-04-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis J.Biol.Chem., 285, 2010
1T2B	Crystal Structure of cytochrome P450cin complexed with its substrate 1,8-cineole Descriptor: 1,3,3-TRIMETHYL-2-OXABICYCLO[2.2.2]OCTANE, P450cin, PROTOPORPHYRIN IX CONTAINING FE Authors: Meharenna, Y.T, Li, H, Hawkes, D.B, Pearson, A.G, De Voss, J, Poulos, T.L. Deposit date: 2004-04-20 Release date: 2005-04-26 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of P450cin in a complex with its substrate, 1,8-cineole, a close structural homologue to D-camphor, the substrate for P450cam Biochemistry, 43, 2004
5IUZ	STRUCTURE OF P450 2B4 F202W MUTANT (CYMAL-5) Descriptor: 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE Authors: Jang, H.-H, Halpert, J.R, Shah, M.B. Deposit date: 2016-03-18 Release date: 2016-06-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.73 Å) Cite: Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry. Biophys.Chem., 216, 2016
6L1B	Crystal Structure of P450BM3 with N-(3-cyclopentylpropanoyl)-L-pipecolyl-L-phenylalanine Descriptor: (2S)-2-[[(2S)-1-(3-cyclopentylpropanoyl)piperidin-2-yl]carbonylamino]-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, DIMETHYL SULFOXIDE, ... Authors: Shoji, O, Yonemura, K. Deposit date: 2019-09-28 Release date: 2020-09-30 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 Acs Catalysis, 10, 2020
3ZSN	Structure of the mixed-function P450 MycG F286A mutant in complex with mycinamicin IV Descriptor: BENZAMIDINE, GLYCEROL, MYCINAMICIN IV, ... Authors: Li, S, Kells, P.M, Rutaganira, F.U, Anzai, Y, Kato, F, Sherman, D.H, Podust, L.M. Deposit date: 2011-06-29 Release date: 2012-05-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Substrate Recognition by the Multifunctional Cytochrome P450 Mycg in Mycinamicin Hydroxylation and Epoxidation Reactions. J.Biol.Chem., 287, 2012

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