PDB: 608 resultsInfo pagesStatus searchChemie searchBIRD

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8P1H	Crystal structure of the chimera of human 14-3-3 zeta and phosphorylated cytoplasmic loop fragment of the alpha7 acetylcholine receptor Descriptor: 1,2-ETHANEDIOL, AZIDE ION, BENZOIC ACID, ... Authors: Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Lyukmanova, E.N, Sluchanko, N.N. Deposit date: 2023-05-12 Release date: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein. Biochem.Biophys.Res.Commun., 682, 2023
8Q1S	Pathogenic mutations of human phosphorylation sites affect protein-protein interactions Descriptor: 1,2-ETHANEDIOL, 14-3-3 protein epsilon, BROMIDE ION, ... Authors: Roske, Y, Daumke, O, Rrustemi, T, Selbach, M. Deposit date: 2023-08-01 Release date: 2024-02-21 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Pathogenic mutations of human phosphorylation sites affect protein-protein interactions. Nat Commun, 15, 2024
8Q4L	GBP1 bound by 14-3-3sigma Descriptor: 14-3-3 protein sigma, Guanylate-binding protein 1 Authors: Pfleiderer, M.M, Liu, X, Fisch, D, Anastasakou, E, Frickel, E.M, Galej, W.P. Deposit date: 2023-08-07 Release date: 2023-10-11 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (5.12 Å) Cite: PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science, 382, 2023
8QT5	Crystal structure of Arabidopsis thaliana 14-3-3 isoform lambda in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein G-BOX factor 14 lambda,Protein BRASSINAZOLE-RESISTANT 1, ACETATE ION Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-10-25 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTC	Crystal structure of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: 14-3-3-like protein GF14 omega, COBALT (II) ION, Protein BRASSINAZOLE-RESISTANT 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTF	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the transcription factor BZR1. Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-12 Release date: 2023-11-22 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
8QTT	Crystal structure of a C-terminally truncated version of Arabidopsis thaliana 14-3-3 omega in complex with a phosphopeptide from the inhibitor protein BKI1. Descriptor: 1,2-ETHANEDIOL, 14-3-3-like protein GF14 omega, BRI1 kinase inhibitor 1, ... Authors: Hothorn, M, Obergfell, E. Deposit date: 2023-10-13 Release date: 2023-11-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Mechanistic insights into the function of 14-3-3 proteins as negative regulators of brassinosteroid signaling in Arabidopsis. Plant Cell.Physiol., 2024
9AXA	CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 Descriptor: 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... Authors: Quade, B, Cohen, S.E, Huang, X. Deposit date: 2024-03-06 Release date: 2024-04-17 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers. Cancer Discov, 2024

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