7W4P
 
 | | The structure of KATP H175K mutant in closed state | | Descriptor: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Chen, L, Wang, M. | | Deposit date: | 2021-11-28 | | Release date: | 2022-06-01 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7W79
 | | Heme exporter HrtBA in complex with Mn-AMPPNP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Putative ABC transport system integral membrane protein, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7W7B
 | | Heme exporter HrtBA in complex with protoporphyrin IX containing manganese(III), high resolution data | | Descriptor: | (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE, DI(HYDROXYETHYL)ETHER, PROTOPORPHYRIN IX CONTAINING MN, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7W7A
 | | Heme exporter in complex with Mn-containing protoporphyrin IX, Mn-anomalous data | | Descriptor: | (1S)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PENTANOYLOXY)METHYL]ETHYL OCTANOATE, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.204 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7W7D
 | | Heme exporter HrtBA in complex with heme | | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Putative ABC transport system integral membrane protein, Putative ABC transport system, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shiro, Y, Shirouzu, M. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7W78
 | | Heme exporter HrtBA in complex with Mg-AMPPNP | | Descriptor: | ACETATE ION, DODECANE, GLYCEROL, ... | | Authors: | Hisano, T, Nakamura, H, Rahman, M.M, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.884 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7W7C
 | | Heme exporter in the unliganded form | | Descriptor: | Putative ABC transport system integral membrane protein, Putative ABC transport system, ATP-binding protein, ... | | Authors: | Rahman, M.M, Hisano, T, Nakamura, H, Tosha, T, Shirouzu, M, Shiro, Y. | | Deposit date: | 2021-12-04 | | Release date: | 2022-06-22 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for heme detoxification by an ATP-binding cassette-type efflux pump in gram-positive pathogenic bacteria.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7T55
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7T57
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7T54
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7T56
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7QKS
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7QKR
 | | Cryo-EM structure of ABC transporter STE6-2p from Pichia pastoris with Verapamil at 3.2 A resolution | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, Dexverapamil, MAGNESIUM ION, ... | | Authors: | Schleker, E.S.M, Reinhart, C. | | Deposit date: | 2021-12-18 | | Release date: | 2022-10-26 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural and functional investigation of ABC transporter STE6-2p from Pichia pastoris reveals unexpected interaction with sterol molecules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TBW
 | | The structure of ATP-bound ABCA1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Sun, Y, Li, X. | | Deposit date: | 2021-12-22 | | Release date: | 2022-01-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Nat Cardiovasc Res, 1, 2022
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7TC0
 | | The structure of human ABCA1 in digitonin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | | Authors: | Sun, Y, Li, X. | | Deposit date: | 2021-12-22 | | Release date: | 2022-01-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Nat Cardiovasc Res, 1, 2022
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7TBZ
 | | The structure of ABCA1 Y482C | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | | Authors: | Sun, Y, Li, X. | | Deposit date: | 2021-12-22 | | Release date: | 2022-01-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Nat Cardiovasc Res, 1, 2022
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7TBY
 | | The structure of human ABCA1 in nanodisc | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | | Authors: | Sun, Y, Li, X. | | Deposit date: | 2021-12-22 | | Release date: | 2022-01-26 | | Last modified: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Nat Cardiovasc Res, 1, 2022
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7TCG
 | | BceAB nucleotide-free conformation | | Descriptor: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB | | Authors: | George, N.L, Orlando, B.J. | | Deposit date: | 2021-12-23 | | Release date: | 2022-04-06 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TCH
 | | BceAB E169Q variant ATP-bound conformation | | Descriptor: | 4-amino-4-deoxy-1-O-[(S)-hydroxy{[(2E,6E,10Z,14Z,18Z,22E,26E,30E)-3,7,11,15,19,23,27,31,35-nonamethylhexatriaconta-2,6,10,14,18,22,26,30,34-nonaen-1-yl]oxy}phosphoryl]-alpha-L-arabinopyranose, ADENOSINE-5'-TRIPHOSPHATE, Bacitracin export ATP-binding protein BceA, ... | | Authors: | George, N.L, Orlando, B.J. | | Deposit date: | 2021-12-23 | | Release date: | 2022-04-06 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Conformational snapshots of the bacitracin sensing and resistance transporter BceAB.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TDT
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7WIT
 | | Structure of SUR1 in complex with mitiglinide | | Descriptor: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | | Authors: | Chen, L, Wang, M.M. | | Deposit date: | 2022-01-04 | | Release date: | 2022-11-16 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Front Pharmacol, 13, 2022
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7WIV
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with an AMP-PNP | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIW
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIX
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mycobactin import ATP-binding/permease protein IrtA, ... | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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7WIU
 | | Cryo-EM structure of Mycobacterium tuberculosis irtAB in inward-facing state | | Descriptor: | Mycobactin import ATP-binding/permease protein IrtA, Mycobactin import ATP-binding/permease protein IrtB | | Authors: | Zhang, B, Sun, S, Yang, H, Rao, Z. | | Deposit date: | 2022-01-05 | | Release date: | 2023-01-25 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB.
Protein Cell, 14, 2023
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