5KFR
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5KG4
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2H6M
| An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | Descriptor: | N-ACETYL-LEUCYL-ALANYL-ALANYL-(N,N-DIMETHYL)-GLUTAMINE-(1,4-DIOXO-3,4-DIHYDRO-1H-PHTHALAZIN-2-YL)METHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE, Picornain 3C | Authors: | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | Deposit date: | 2006-05-31 | Release date: | 2006-08-08 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors. J.Mol.Biol., 361, 2006
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1POV
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3NFQ
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6FFA
| FMDV Leader protease bound to substrate ISG15 | Descriptor: | GLYCEROL, Lbpro, SULFATE ION, ... | Authors: | Swatek, K.N, Pruneda, J.N, Komander, D. | Deposit date: | 2018-01-05 | Release date: | 2018-02-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8AG4
| Vaccinia C16 protein bound to Ku70/Ku80 | Descriptor: | Protein C10, X-ray repair cross-complementing protein 5, X-ray repair cross-complementing protein 6 | Authors: | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | Deposit date: | 2022-07-19 | Release date: | 2022-11-09 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
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8AG5
| Vaccinia C16 protein bound to Ku70/Ku80 | Descriptor: | Ku70-Xrcc6, Protein C10, X-ray repair cross-complementing protein 5 | Authors: | Rivera-Calzada, A, Arribas-Bosacoma, R, Pearl, L.H, Llorca, O. | Deposit date: | 2022-07-19 | Release date: | 2022-11-09 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus. Nat Commun, 13, 2022
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4BPU
| Crystal structure of human primase in heterodimeric form, comprising PriS and truncated PriL lacking the C-terminal Fe-S domain. | Descriptor: | DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, GLYCEROL, ... | Authors: | Kilkenny, M.L, Perera, R.L, Pellegrini, L. | Deposit date: | 2013-05-28 | Release date: | 2013-09-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering Proc.Natl.Acad.Sci.USA, 110, 2013
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5HDA
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4BPW
| Crystal structure of human primase bound to UTP | Descriptor: | DNA PRIMASE LARGE SUBUNIT, DNA PRIMASE SMALL SUBUNIT, MAGNESIUM ION, ... | Authors: | Kilkenny, M.L, Perera, R.L, Pellegrini, L. | Deposit date: | 2013-05-28 | Release date: | 2013-09-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering Proc.Natl.Acad.Sci.USA, 110, 2013
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1S7O
| Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes | Descriptor: | Hypothetical UPF0122 protein SPy1201/SpyM3_0842/SPs1042/spyM18_1152 | Authors: | Oganesyan, V, Pufan, R, DeGiovanni, A, Yokota, H, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-01-29 | Release date: | 2004-06-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes. Acta Crystallogr.,Sect.D, 60, 2004
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2LOX
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2DB9
| Solution structure of the plus-3 domain of human KIAA0252 protein | Descriptor: | Paf1/RNA polymerase II complex component | Authors: | Yoneyama, M, Kigawa, T, Tochio, N, Nameki, N, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-12-15 | Release date: | 2006-06-15 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the plus-3 domain of human KIAA0252 protein To be Published
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2QUS
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3GJW
| PARP complexed with A968427 | Descriptor: | 7-(pyrrolidin-1-ylmethyl)pyrrolo[1,2-a]quinoxalin-4(5H)-one, Poly [ADP-ribose] polymerase 1 | Authors: | Park, C.H. | Deposit date: | 2009-03-09 | Release date: | 2010-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) Bioorg.Med.Chem.Lett., 19, 2009
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7UWN
| Structure of the IL-17A-IL-17RA-IL-17RC ternary complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | Authors: | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-03 | Release date: | 2022-07-27 | Last modified: | 2022-09-28 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Organizing structural principles of the IL-17 ligand-receptor axis. Nature, 609, 2022
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1EAH
| PV2L COMPLEXED WITH ANTIVIRAL AGENT SCH48973 | Descriptor: | 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE, MYRISTIC ACID, POLIOVIRUS TYPE 2 COAT PROTEINS VP1 TO VP4 | Authors: | Lentz, K, Arnold, E. | Deposit date: | 1997-07-22 | Release date: | 1998-09-16 | Last modified: | 2023-04-19 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes. Structure, 5, 1997
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2M14
| NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and Rad4 | Descriptor: | DNA repair protein RAD4, RNA polymerase II transcription factor B subunit 1 | Authors: | Lafrance-Vanasse, J, Arseneault, G, Cappadocia, L, Legault, P, Omichinski, J.G. | Deposit date: | 2012-11-16 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and functional evidence that Rad4 competes with Rad2 for binding to the Tfb1 subunit of TFIIH in NER. Nucleic Acids Res., 41, 2013
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6ZUZ
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6Z4X
| Structure of the CAK complex form Chaetomium thermophilum bound to ATP-gamma-S | Descriptor: | CHLORIDE ION, CYCLIN domain-containing protein, MAGNESIUM ION, ... | Authors: | Peissert, S, Kuper, J, Kisker, C. | Deposit date: | 2020-05-26 | Release date: | 2020-12-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Structural basis for CDK7 activation by MAT1 and Cyclin H. Proc.Natl.Acad.Sci.USA, 117, 2020
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2K2U
| NMR Structure of the complex between Tfb1 subunit of TFIIH and the activation domain of VP16 | Descriptor: | Alpha trans-inducing protein, RNA polymerase II transcription factor B subunit 1 | Authors: | Langlois, C, Mas, C, Di Lello, P, Miller Jenkins, P.M, Legault, J, Omichinski, J.G. | Deposit date: | 2008-04-11 | Release date: | 2008-08-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR Structure of the Complex between the Tfb1 Subunit of TFIIH and the Activation Domain of VP16: Structural Similarities between VP16 and p53. J.Am.Chem.Soc., 130, 2008
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5JW9
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2EYQ
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1TFB
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