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8I1N	Crystal structure of APSK2 domain from human PAPSS2 in complex with endogenous APS and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Authors: Zhang, L, Song, W.Y, Zhang, L. Deposit date: 2023-01-13 Release date: 2023-06-28 Last modified: 2023-07-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2. Structure, 31, 2023
8I1O	Crystal structure of APSK2 domain from human PAPSS2 in complex with exogenous APS and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-PHOSPHOSULFATE, Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Authors: Zhang, L, Song, W.Y, Zhang, L. Deposit date: 2023-01-13 Release date: 2023-06-28 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Redox switching mechanism of the adenosine 5'-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2. Structure, 31, 2023
2H2Q	Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase Descriptor: 2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Senkovich, O, Schormann, N, Chattopadhyay, D. Deposit date: 2006-05-19 Release date: 2008-04-08 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function. Proteins, 73, 2008
6MBF	GphF Dehydratase 1 Descriptor: GphF Dehydratase 1, MAGNESIUM ION Authors: Dodge, G.J, Smith, J.L. Deposit date: 2018-08-29 Release date: 2018-09-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.543 Å) Cite: Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase. ACS Chem. Biol., 13, 2018
6MBH	GphF DH1 P1711L, L1744P variant: An isomerase-inactive variant of GphF DH1 Descriptor: GphF Dehydratase 1 Authors: Dodge, G.J, Smith, J.L. Deposit date: 2018-08-29 Release date: 2018-09-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase. ACS Chem. Biol., 13, 2018
6MBG	GphF Dehydratase P1711L variant for improved crystallization Descriptor: 1,4-BUTANEDIOL, GphF, MAGNESIUM ION Authors: Dodge, G.J, Smith, J.L. Deposit date: 2018-08-29 Release date: 2018-09-19 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.852 Å) Cite: Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase. ACS Chem. Biol., 13, 2018
4LAB	Crystal structure of the catalytic domain of RluB Descriptor: CHLORIDE ION, PLATINUM (II) ION, Ribosomal large subunit pseudouridine synthase B Authors: Czudnochowski, N, Finer-Moore, J.S, Stroud, R.M. Deposit date: 2013-06-19 Release date: 2013-11-20 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5043 Å) Cite: The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs. Nucleic Acids Res., 42, 2014
3BKX	Crystal structure of cyclopropane-fatty-acyl-phospholipid synthase-like protein (YP_807781.1) from Lactobacillus casei ATCC 334 at 1.85 A resolution Descriptor: CHLORIDE ION, SAM-dependent methyltransferase Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2007-12-07 Release date: 2007-12-18 Last modified: 2023-01-25 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Crystal structure of cyclopropane-fatty-acyl-phospholipid synthase-like protein (YP_807781.1) from Lactobacillus casei ATCC 334 at 1.85 A resolution To be published
5EJZ	Bacterial Cellulose Synthase Product-Bound State Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-deoxy-2-fluoro-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ... Authors: Morgan, J.L.W, Zimmer, J. Deposit date: 2015-11-02 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Observing cellulose biosynthesis and membrane translocation in crystallo. Nature, 531, 2016
6DGJ	Cronobacter turicensis RpfR quorum-sensing receptor PAS domain in complex with BDSF Descriptor: (2Z)-dodec-2-enoic acid, RpfR Authors: Waldron, E.J, Neiditch, M.B. Deposit date: 2018-05-17 Release date: 2019-01-02 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.294 Å) Cite: Structural basis of DSF recognition by its receptor RpfR and its regulatory interaction with the DSF synthase RpfF. PLoS Biol., 17, 2019
5KTL	Dihydrodipicolinate synthase from the industrial and evolutionarily important cyanobacteria Anabaena variabilis. Descriptor: 4-hydroxy-tetrahydrodipicolinate synthase, MANGANESE (II) ION Authors: Christensen, J.B, Panjikar, S, Perugini, M. Deposit date: 2016-07-11 Release date: 2016-11-30 Method: X-RAY DIFFRACTION (1.92 Å) Cite: Structure and Function of Cyanobacterial DHDPS and DHDPR. Sci Rep, 6, 2016
2NQP	Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA Descriptor: POTASSIUM ION, tRNA pseudouridine synthase A, transfer RNA Authors: Hur, S, Stroud, R.M. Deposit date: 2006-10-31 Release date: 2007-05-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.5 Å) Cite: How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. Mol.Cell, 26, 2007
3A8E	The structure of AxCesD octamer complexed with cellopentaose Descriptor: Cellulose synthase operon protein D, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose Authors: Hu, S.Q, Tajima, K, Zhou, Y, Yao, M, Tanaka, I. Deposit date: 2009-10-05 Release date: 2010-09-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of bacterial cellulose synthase subunit D octamer with four inner passageways Proc.Natl.Acad.Sci.USA, 107, 2010
5MLZ	Dolichyl phosphate mannose synthase in complex with GDP and Mg2+ Descriptor: CHLORIDE ION, Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. Deposit date: 2016-12-08 Release date: 2017-08-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
5MLQ	Structure of CDPS from Nocardia brasiliensis Descriptor: CDPS, CITRIC ACID Authors: Bourgeois, G, Seguin, J, Moutiez, M, Babin, M, Belin, P, Mechulam, Y, Gondry, M, Schmitt, E. Deposit date: 2016-12-07 Release date: 2018-05-02 Last modified: 2019-05-15 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Structural basis for partition of the cyclodipeptide synthases into two subfamilies. J.Struct.Biol., 203, 2018
5MM0	Dolichyl phosphate mannose synthase in complex with GDP-mannose and Mn2+ (donor complex) Descriptor: CHLORIDE ION, Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... Authors: Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. Deposit date: 2016-12-08 Release date: 2017-08-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
2NR0	Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA Descriptor: leucyl tRNA, tRNA pseudouridine synthase A Authors: Hur, S, Stroud, R.M. Deposit date: 2006-11-01 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.9 Å) Cite: How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. Mol.Cell, 26, 2007
2NRE	Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA Descriptor: POTASSIUM ION, leucyl tRNA, tRNA pseudouridine synthase A Authors: Hur, S, Stroud, R.M. Deposit date: 2006-11-01 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (4 Å) Cite: How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. Mol.Cell, 26, 2007
5MM1	Dolichyl phosphate mannose synthase in complex with GDP and dolichyl phosphate mannose Descriptor: Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE, dolichyl phosphate mannose Authors: Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. Deposit date: 2016-12-08 Release date: 2017-08-09 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
6NCS	Crystal structure of N-acetylneuraminic acid (Sialic acid) synthetase from Leptospira borgpetersenii serovar Hardjo-bovis in complex with citrate Descriptor: ACETATE ION, CITRIC ACID, D(-)-TARTARIC ACID, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2018-12-12 Release date: 2018-12-26 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of N-acetylneuraminic acid (Sialic acid) synthetase from Leptospira borgpetersenii serovar Hardjo-bovis in complex with citrate to be published
1R0E	Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor Descriptor: 3-[3-(2,3-DIHYDROXY-PROPYLAMINO)-PHENYL]-4-(5-FLUORO-1-METHYL-1H-INDOL-3-YL)-PYRROLE-2,5-DIONE, CITRATE ANION, Glycogen synthase kinase-3 beta Authors: Allard, J, Nikolcheva, T, Gong, L, Wang, J, Dunten, P, Avnur, Z, Waters, R, Sun, Q, Skinner, B. Deposit date: 2003-09-20 Release date: 2004-10-12 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.25 Å) Cite: From genetics to therapeutics: the Wnt pathway and osteoporosis To be Published
5OLT	Crystal structure of the extramembrane domain of the cellulose biosynthetic protein BcsG from Salmonella typhimurium Descriptor: CITRIC ACID, Cellulose biosynthesis protein BcsG, ZINC ION Authors: Vella, P, Polyakova, A, Lindqvist, Y, Schnell, R, Bourenkov, G, Schneider, T, Schneider, G. Deposit date: 2017-07-28 Release date: 2018-08-08 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural and Functional Characterization of the BcsG Subunit of the Cellulose Synthase in Salmonella typhimurium. J. Mol. Biol., 430, 2018
8D5H	Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin Descriptor: 6-HYDROXYMETHYLPTERIN, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Stogios, P.J, Skarina, T, Osipiuk, J, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2022-06-04 Release date: 2022-06-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin To Be Published
8D5G	Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin pyrophosphate Descriptor: 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, CHLORIDE ION, folP-SMZ_B27 Authors: Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2022-06-04 Release date: 2022-06-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.78 Å) Cite: Crystal structure of dihydropteroate synthase (folP-SMZ_B27) from soil uncultured bacterium in complex with 6-hydroxymethyl-7,8-dihydropterin pyrophosphate To Be Published
3AJ2	The structure of AxCeSD octamer (C-terminal HIS-tag) from Acetobacter xylinum Descriptor: Cellulose synthase operon protein D Authors: Hu, S.Q, Tajima, K, Zhou, Y, Tanaka, I, Yao, M. Deposit date: 2010-05-20 Release date: 2010-10-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structure of bacterial cellulose synthase subunit D octamer with four inner passageways Proc.Natl.Acad.Sci.USA, 107, 2010

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