3I4M
 
 | | 8-oxoguanine containing RNA polymerase II elongation complex D | | Descriptor: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Damsma, G.E, Cramer, P. | | Deposit date: | 2009-07-02 | | Release date: | 2009-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Molecular basis of transcriptional mutagenesis at 8-oxoguanine
J.Biol.Chem., 284, 2009
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3I4N
 | | 8-oxoguanine containing RNA polymerase II elongation complex E | | Descriptor: | DNA (5'-D(*AP*G*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP*(8OG)P*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*T)-3'), DNA (5'-D(*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Damsma, G.E, Cramer, P. | | Deposit date: | 2009-07-02 | | Release date: | 2009-09-08 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.9 Å) | | Cite: | Molecular basis of transcriptional mutagenesis at 8-oxoguanine
J.Biol.Chem., 284, 2009
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4WQS
 | | Thermus thermophilus RNA polymerase backtracked complex | | Descriptor: | DNA (28-MER), DNA (5'-D(P*GP*TP*AP*GP*CP*TP*TP*GP*TP*GP*GP*TP*AP*GP*TP*GP*AP*CP*GP*AP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... | | Authors: | Murayama, Y, Sekine, S, Yokoyama, S. | | Deposit date: | 2014-10-22 | | Release date: | 2015-02-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (4.306 Å) | | Cite: | The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions.
Mol.Cell, 57, 2015
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7EU0
 | | The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | | Descriptor: | DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... | | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | | Deposit date: | 2021-05-15 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Science, 374, 2021
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7EU1
 | | The cryo-EM structure of A. thaliana Pol IV-RDR2 holoenzyme | | Descriptor: | DNA-directed RNA polymerase IV subunit 1, DNA-directed RNA polymerases II and IV subunit 5A, DNA-directed RNA polymerases II, ... | | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | | Deposit date: | 2021-05-15 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.86 Å) | | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA.
Science, 374, 2021
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8DH0
 | | T7 RNA polymerase elongation complex with unnatural base dDs | | Descriptor: | GLYCEROL, Non-template strand DNA, RNA, ... | | Authors: | Oh, J, Wang, D. | | Deposit date: | 2022-06-24 | | Release date: | 2023-02-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Nat Commun, 14, 2023
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4WZM
 | | Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed with RNA | | Descriptor: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | | Authors: | Verdaguer, N, Ferrer-Orta, C, de la Higuera, N. | | Deposit date: | 2014-11-20 | | Release date: | 2015-05-06 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
J.Virol., 89, 2015
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6N58
 | | Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation II | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | | Deposit date: | 2018-11-21 | | Release date: | 2020-02-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
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5LVF
 | | Solution structure of Rtt103 CTD-interacting domain bound to a Thr4 phosphorylated CTD peptide | | Descriptor: | PRO-SER-TYR-SER-PRO-PTH-SER-PRO-SER-TYR-SER-PRO-THR-SER-PRO-SER, Regulator of Ty1 transposition protein 103 | | Authors: | Jasnovidova, O, Kubicek, K, Krejcikova, M, Stefl, R. | | Deposit date: | 2016-09-14 | | Release date: | 2017-05-10 | | Last modified: | 2019-10-30 | | Method: | SOLUTION NMR | | Cite: | Structural insight into recognition of phosphorylated threonine-4 of RNA polymerase II C-terminal domain by Rtt103p.
EMBO Rep., 18, 2017
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4WZQ
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6NPW
 | | SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide | | Descriptor: | PHOSPHATE ION, Ser2/Ser5 phosphorylated peptide, Ssu72 ortholog, ... | | Authors: | Irani, S, Zhang, Y. | | Deposit date: | 2019-01-18 | | Release date: | 2019-04-24 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.486 Å) | | Cite: | Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
J.Biol.Chem., 294, 2019
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5NSS
 | | Cryo-EM structure of RNA polymerase-sigma54 holoenzyme with promoter DNA and transcription activator PspF intermedate complex | | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta', ... | | Authors: | Glyde, R, Ye, F.Z, Darbari, V.C, Zhang, N, Buck, M, Zhang, X.D. | | Deposit date: | 2017-04-26 | | Release date: | 2017-06-28 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | Structures of RNA Polymerase Closed and Intermediate Complexes Reveal Mechanisms of DNA Opening and Transcription Initiation.
Mol. Cell, 67, 2017
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7KKF
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5MDT
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3QQC
 | | Crystal structure of archaeal Spt4/5 bound to the RNAP clamp domain | | Descriptor: | DNA-directed RNA polymerase subunit b, DNA-directed RNA polymerase subunit a', DNA-directed RNA polymerase subunit A'', ... | | Authors: | Martinez-Rucobo, F.W. | | Deposit date: | 2011-02-15 | | Release date: | 2011-03-23 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity.
Embo J., 30, 2011
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6N57
 | | Cryo-EM structure of Escherichia coli RNAP polymerase bound with TraR in conformation I | | Descriptor: | CHAPSO, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | Authors: | Chen, J, Chiu, C.E, Campbell, E.A, Darst, S.A. | | Deposit date: | 2018-11-21 | | Release date: | 2020-02-26 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | E. coliTraR allosterically regulates transcription initiation by altering RNA polymerase conformation.
Elife, 8, 2019
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8A8F
 | | Crystal structure of Glc7 phosphatase in complex with the regulatory region of Ref2 | | Descriptor: | MANGANESE (II) ION, PHOSPHATE ION, RNA end formation protein 2, ... | | Authors: | Carminati, M, Manav, C.M, Bellini, D, Passmore, L.A. | | Deposit date: | 2022-06-22 | | Release date: | 2023-11-29 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A direct interaction between CPF and RNA Pol II links RNA 3' end processing to transcription.
Mol.Cell, 83, 2023
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7Z0O
 | | Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA | | Descriptor: | Histone H3, Histone H4, Non-template DNA, ... | | Authors: | Baudin, F, Murciano, B, Fung, H.K.H, Fromm, S.A, Mueller, C.W. | | Deposit date: | 2022-02-23 | | Release date: | 2022-04-27 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanism of RNA polymerase I selection by transcription factor UAF.
Sci Adv, 8, 2022
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3AYH
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7NVX
 | | TFIIH in a post-translocated state (with ADP-BeF3) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, CDK-activating kinase assembly factor MAT1, ... | | Authors: | Aibara, S, Schilbach, S, Cramer, P. | | Deposit date: | 2021-03-16 | | Release date: | 2021-05-05 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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7NVW
 | | TFIIH in a pre-translocated state (without ADP-BeF3) | | Descriptor: | CDK-activating kinase assembly factor MAT1, General transcription and DNA repair factor IIH helicase subunit XPB, General transcription factor IIE subunit 1, ... | | Authors: | Aibara, S, Schilbach, S, Cramer, P. | | Deposit date: | 2021-03-16 | | Release date: | 2021-05-05 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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8ORQ
 | | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase open clamp conformation | | Descriptor: | DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... | | Authors: | Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | | Deposit date: | 2023-04-17 | | Release date: | 2024-04-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.
Nucleic Acids Res., 52, 2024
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8P2I
 | | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation with Spt4/5 | | Descriptor: | DNA-directed RNA polymerase subunit Rpo10, DNA-directed RNA polymerase subunit Rpo11, DNA-directed RNA polymerase subunit Rpo12, ... | | Authors: | Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | | Deposit date: | 2023-05-16 | | Release date: | 2024-04-24 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment.
Nucleic Acids Res., 52, 2024
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7NVV
 | | XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, General transcription and DNA repair factor IIH helicase subunit XPB, ... | | Authors: | Aibara, S, Schilbach, S, Cramer, P. | | Deposit date: | 2021-03-16 | | Release date: | 2021-05-05 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes.
Nature, 594, 2021
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4YGX
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